Biomedical subjects
C Worthington
Publications and source records attributed to C Worthington.
Meningioma cysts.
We studied six cases of intracranial meningioma with cyst formation. Manifestations included focal neurologic signs (four cases), seizures (three cases), headache (three cases), and personality changes (two cases). CT revealed a cystic enhancing supratentorial lesion in five cases. Angiographic changes of meningioma were observed in only three cases, and correct preoperative diagnosis was made in only half the cases so studied. Histologically, all lesions were syncytial meningiomas. Cyst fluid was always xanthochromic, acellular, and highly proteinaceous. The variety of anatomic configurations suggests several pathophysiologic mechanisms in formation of the cysts that are commonly misdiagnosed preoperatively. Tissue analysis is needed for all cystic, enhancing lesions of the brain.
Tension pneumocephalus after evacuation of chronic subdural hematoma and subsequent treatment with continuous lumbar subarachnoid infusion and craniostomy drainage.
We present a case of tension pneumocephalus after burr hole evacuation of bilateral chronic subdural hematomas. Subsequent treatment was effected with combined twist drill closed system drainage and continuous intrathecal infusion of a physiological solution. The clinical entity, tension pneumocephalus, and the use of continuous subarachnoid infusion and drainage as a method of cerebral reexpansion are discussed.
Internal carotid artery agenesis: correlation by conventional and digital subtraction angiography, and by computed tomography.
A case is presented of agenesis of the right internal carotid artery in a fifteen-year-old female with an unrelated seizure disorder. Conventional angiography revealed an absent right internal carotid artery, supply to the right anterior cerebral artery from the left internal carotid artery, and supply to the right middle cerebral artery by anastomosis through the vertebral basilar system. The congenital nature of the anomaly was confirmed by intravenous digital subtraction angiography, which revealed no portion or remnant of the right internal carotid artery to be present, and by computerized tomography of the base of the skull, which demonstrated no bony carotid canal on the right side. This is the first reported case of internal carotid artery agenesis to be elucidated by intravenous digital subtraction angiography. A brief discussion concerning the congenital nature of this anomaly is presented, including the role of angiography and computed tomography in establishing the diagnosis of this condition.
Dietitians' wages & salaries.
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The effects of methaqualone on the seizure susceptibility of mice.
Methaqualone produces dose- and time-dependent decreases in susceptibility to electrically, chemically, and sound-induced seizures. The antagonism of methaqualone to electroconvulsive shock can be dissociated from its effects on temperature regulation and plasma corticosterone. Studies with SKF525A, a drug known to block enzymes in the liver that metabolize drugs, suggest that methaqualone, rather than a metabolite produced in the liver, is responsible for its anticonvulsant effects. Tolerance to the anticonvulsant effects of methaqualone is also demonstrated.
Proceedings: Primordial follicles in the ovary of the neonatal ewe lamb.
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Melvin Henry Knisely: 1904-1975.
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Melvin Henry Knisely.
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Stereoscopic digital subtraction angiography in neuroradiologic assessment.
Digital subtraction angiography (DSA) with stereoscopic imaging was performed in 40 patients for evaluation of a variety of cerebrospinal disorders. It was facilitated by a C-arm mounted x-ray tube and imaging chain with 7 degrees angulation between image pairs. Stereoscopic digital imaging proved particularly useful in the preoperative assessment of aneurysms, arteriovenous malformations, and primary and metastatic tumors. The technique was also found to be useful as a real-time adjunct to therapeutic radiographic procedures, as an aid in stereotaxic procedures, and in follow-up of postsurgical patients. Although the intravenous route was occasionally used, especially in postoperative follow-up of aneurysms, the procedure was most often carried out via an intraarterial approach. Stereoscopy was useful in supplying depth information regarding the relations between lesions and surrounding normal and abnormal vasculature. This technique combines the demonstrated advantages of intraarterial DSA with the unique advantage of stereoscopic imaging to demonstrate three-dimensional detail, thus contributing significantly to diagnostic confidence. Disadvantages are discussed. Further refinements in the equipment are expected: generation of stereo images with one injection, thus increasing procedure efficiency and patient safety; a video stereoscopic viewing unit; and the ability to obtain precise measurements via computer of depth, position, distance between, and true size of objects.