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Biomedical subjects

C Wood

Publications and source records attributed to C Wood.

At least 577 records · Page 32Linked to original sources
PubMedDate not supplied

Ovarian and peripheral venous blood prostaglandin F2alpha levels in pregnant and nonpregnant women.

Prostaglandin F2alpha (PGF2alpha) was measured by radioimmunoassay in human blood plasma collected from both ovarian veins and from a peripheral vein in eight pregnant and seven nonpregnant women. In the pregnant women, significantly higher levels of PGF2alpha were found in venous blood plasma taken from the ovary which contained the corpus luteum than were found in either the ovarian vein blood plasma from the opposite ovary or in the blood plasma from a peripheral vein. Thus, PGF2alpha levels in the venous blood plasma from the ovary without a corpus luteum were not significantly different from those found in the peripheral venous blood plasma. In seven nonpregnant women, significantly higher levels of PGF2alpha were found in the venous blood plasma taken from the ovary which contained a corpus luteum than were found in the blood plasma taken from a peripheral vein. The former levels did not differ significantly from those found in the venous blood plasma taken from the ovary without a corpus luteum in these nonpregnant women. Thus, in nonpregnant women a significant difference was found between PGF2alpha levels in the venous blood plasma from the ovary without a corpus luteum and those in peripheral venous blood plasma.

Female↗
PubMedDate not supplied

Pituitary response to LHRH during the puerperium in women.

Five breast-feeding women received 100 mug synthetic LHRH at between 19 and 58 days post-partum. One subject was treated twice. LH and FSH responses were monitored using radioimmunoassay. In four women treated at 19,21,29 and 51 days post-partum, the FSH response was greater than the LH response which was absent altogether in three of these women. In two women who were treated at 52 and 58 days both LH and FSH levels was elevated with the LH response being greater than the FSH response. This change in the pattern of pituitary response is considered in relation to the post-partum anovulatory condition.

Female↗
PubMedDate not supplied

Comparative evaluation of bovine immunodeficiency-like virus infection by reverse transcriptase and polymerase chain reaction.

Infection of embryonic bovine lung (EBL) cells by bovine immunodeficiency-like virus (BIV) were monitored by reverse transcriptase (RT), syncytia formation and polymerase chain reaction (PCR). Infection can be detected by PCR at 24 h while the presence of syncytia and RT were not detected until much later. The detection of BIV RT can be optimized by changing the pH and salt conditions. The enzyme is very sensitive to changes in pH but can tolerate a wider range of salt and MgCl2 concentrations. Infection of primary human cell cultures by BIV was monitored by both PCR and RT. No active infection of human cells were detectable.

Animals↗
PubMedDate not supplied

A community hospital's effort to expedite treatment for patients with chest pain.

OBJECTIVE: The purpose of this study was to determine treatment times at a community hospital that does not receive prehospital electrocardiogram (ECG) transmission and to determine the effect of time to first hospital ECG on overall door-to-drug time. DESIGN: Descriptive. SETTING: 238-bed Regional Medical Center in Burlington, North Carolina. SAMPLE: One hundred four patients with a final diagnosis of acute myocardial infarction were included in this 16-month study. RESULTS: A median door-to-ECG time of 5 minutes was within the American College of Cardiology/American Heart Association recommendation of 10 minutes. Shorter treatment times to obtain the first ECG and initiate thrombolytic therapy were associated with younger patients and those arriving by ambulance. CONCLUSIONS: While efficiency in obtaining a first hospital ECG on patients with suspected acute myocardial infarctions was achieved, this did not result in low door-to-drug times. Further streamlining of protocol and the exploration of prehospital initiatives may result in a significant reduction in door-to-drug times.

Chest Pain↗
PubMedDate not supplied

The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure.

Ovarian steroid replacement therapy in the ovariectomized ewe, given in the correct sequence to mimic endogenous steroid changes in the normal ovulatory cycle, allows the development of embryos transferred in utero. A similar type of sequential therapy was designed for steroid replacement in women with primary ovarian failure. This produces the histological changes in uterine endometrial morphology and plasma oestradiol and progesterone similar to those observed in the normal ovulatory cycle. We now report that in one of these women a donated oocyte, fertilized by her husband's spermatozoa and cultured to the two-cell stage in vitro, was transferred in utero, resulting in a normal pregnancy and the delivery of a healthy child. Oestrogen therapy was withdrawn at 12 weeks and progesterone at 19 weeks gestation. This technique allows the treatment of human infertility due to primary ovarian failure.

Embryo Transfer↗