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Biomedical subjects

C Wastell

Publications and source records attributed to C Wastell.

At least 73 records · Page 4Linked to original sources

Pneumatosis cystoides intestinalis. Report of two cases involving the descending colon.

Two cases of pneumatosis cystoides intestinalis of the descending colon are described in which the presenting symptoms were abdominal pain and changed bowel habits, respectively. The diagnosis in both cases was established radiologically and sigmoidoscopically. Because the symptoms were persistent and severe, surgical excision of the involved segment of the large bowel was performed. The postoperative result was good and both patients remain free of symptoms.

Colonic Diseases↗

The effect of hepatic interposition on insulin-stimulated gastric secretion after proximal gastric vagotomy.

The peak acid output to insulin 10-14 days after proximal gastric vagotomy (PGV) for uncomplicated duodenal ulcer in a control group of 11 men was 1.5 mmol/h, and this rose significantly (P less than 0.01) after a mean interval of 26.1 months to 5.3 mmol/h. The rise in the PAOI in 7 male patients undergoing PGV and hepatic interposition for duodenal ulcer was from 1.0 mmol/h to 4.5 mmol/h (P less than 0.05) over a mean interval of 13.1 months. No significant difference between the changes in the PAOI in the two groups of patients could be detected. It is concluded that separation of the lesser curve of the stomach from the cut edge of the lesser omentum by the left lobe of the liver after PGV in an attempt to block vagal regeneration does not alter the postoperative rise in acid secretion.

Gastric Juice↗

Effect of various pyloroplasties on fecal fat excretion in dogs and humans.

Fecal fat excretion has been measured both before and after truncal vagotomy and pyloroplasty in patients with chronic duodenal ulcer, and pyloroplasty alone, in dogs. In 13 patients the mean increase in fecal fat after truncal vagotomy and Heineke-Mikulicz pyloroplasty was 2.34 g/24 hr. After truncal vagotomy and Finney pyloroplasty in 12 patients the increase was similar and was 3.09 g/24 hr. Fecal fat was also measured before and after a 3-cm, a 6-cm Heineke-Mikulicz, and a Finney type of pyloroplasty in dogs. The area resulting from the pyloroplasties was measured. Pyloroplasty by itself resulted in a significant increase in fecal fat but no correlation could be found between the magnitude of the increase and the area that resulted from the pyloroplasties.

Animals↗

Prospectively randomised trial of proximal gastric vagotomy either with or without pyloroplasty in treatment of uncomplicated duodenal ulcer.

A consecutive series of 100 men with uncomplicated duodenal ulcer was randomly divided into two groups: one group of 52 underwent proximal gastric vagotomy (PGV), the other group (48) underwent PGV with pyloroplasty (PGVP). Preoperative peak acid output (PAOP) was measured in all patients. Those with a higher preoperative PAOP were significantly more likely to develop recurrent ulceration. Three patients developed recurrent ulceration after PGV and seven after PGVP. Dumping was both more common and more severe after PGVP than PGV. An overall satisfactory result was achieved in 92% after PGV and 81% after PGVP. We conclude that combining pyloroplasty with PGV has no appreciable advantages.

Diarrhea↗

Fissure-in-ano.

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Female↗

Selective proximal vagotomy with and without pyloroplasty.

The early results of a prospective randomized clinical trial of selective proximal vagotomy with and without gastric drainage in a total of 36 patients are reported. In spite of adequate average acid reduction and little evidence of gastric retention two definite recurrent ulcers have occurred in the 16 patients who did not have a pyloroplasty. Further trials of the effect of selective proximal vagotomy without gastric drainage are necessary before the procedure is widely adopted.

Barium Sulfate↗