Effects of acute and chronic morphine on regional rat brain acetylcholine turnover rate.
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Biomedical subjects
Publications and source records attributed to C Wang.
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Computer techniques were employed to construct a respiratory control model in which the variables treated were programmed according to a series of mathematical equations, with the purpose of eliciting the relationship of V-PCO2 (minute ventilation-partial pressure of carbon dioxide) on a transient time basis. It was discovered that the transient V-PCO2 relationship has the shape of a loop half of which is for on-CO2 and the other half for off-CO2. Breath-by-breath ventilation was calculated by means of a home-made computer and the V-PCO2 relationship was monitored on an XY plotter. The transient V-PCO2 course also showed a loop which was quite similar in the general shape to the one traced employing theoretical analysis with an analog computer. This V-PCO2 loop may have potential usefulness to reveal mechanisms of respiratory control which may not be shown by the conventional V-PCO2 response curves.
The cochlear microphonic response was measured with differential electrodes from the first and third cochlear turns of normal guinea pigs and those treated with the ototoxic drug kanamycin. Histological controls showed that the outer hair cells in treated animals were missing over the basal half of the damaged cochleas, while the inner hair cells were intact. Measurements are consistent with the hypothesis that the potentials produced by inner hair cells are proportional to the velocity of the basilar membrane, whereas potentials generated by outer hair cells (which dominate the response of normal cochleas) are proportional displacement of the basilar membrane.
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Thermal polymers of arginine, glutamic acid, glycine, histidine, phenylalanine, and tryptophan have melanocyte-stimulating activity. The fact that similar polymers lack such activity indicates that the effect is related to the specific amino acid residues. The active polymers are discussed as a model of an evolutionary precursor of contemporary melanocyte-stimulating hormone.
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