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Biomedical subjects

C Walter

Publications and source records attributed to C Walter.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Ventral abdominal wall defects--antenatal diagnosis, course of pregnancy and post partum therapy].

The article reports on antepartal sonographic diagnosis and the course and completion of 27 cases with ventral abdominal wall defects. There were 17 cases of omphalocele, 4 cases of gastroschisis and 6 cases of complex ventral abdominal wall defects with associated malformations. In 23 of the 26 women examined prenatally via sonography (89%), the diagnosis was ventral abdominal wall defect. In the 3 cases not diagnosed via sonography, there was one case of intrauterine foetal death. In another case, Potter's syndrome with anhydramnion was found besides a foetal abdominal wall defect, whereas the last unrecognised case had been subjected to sonographic examination outside the hospital only. In 13 out of 17 cases (77%) with omphalocele there were additional malformations. On the other hand, no further associated malformations were seen in the 4 patients with gastroschisis. Complex abdominal wall defects (in the sense of total abdominal wall aplasias or thoracoabdominal gastroschisis, etc.) with multiple associated malformations occurred in the remaining 6 cases. The most frequently seen associated malformations in children with omphalocele were neural tube defects and skeletal malformations (35% each), followed by cardiac and vascular malformations and malformations of the digestive tract. In those women examined in our clinic via sonography who had foetal abdominal wall defects, amniotic anomalies were seen (hydramnion 44%, oligohydramnion 13%). Chromosomal anomalies occurred in omphalocele with 35% incidence. The results obtained point to the necessity of conducting detailed and accurate sonographic examination if a foetal abdominal wall defect is discovered, in order to exclude or confirm further associated malformations.(ABSTRACT TRUNCATED AT 250 WORDS)

Abdominal Muscles↗
PubMed1985

[Sonographic diagnosis of severe fetal malformations].

The present paper reports on results of ultrasonographic examination in the identification of severe congenital malformations in the period between 1975 and 1982. The incidence of severe congenital malformations in relation to the total number of births during this period was 159 out of 11,372 (1.4%). In 144 cases with severe malformations at least one antenatal ultrasonographic examination had been performed. According to their topographic location, 42% of these were head/neural tube defects, 38% trunk/organ defects, only 2% were severe defects of the extremities and 18% were rare fetal malformations. As a result of previous ultrasonographic examinations at specialists' practices 60% of the cases were referred to the authors' clinic for further clarification with a correct diagnosis or a suspected fetal malformation. Of all the sonographically demonstrable structural defects of the fetus, 81% of all severe fetal defects seen at the authors' clinic during the period in question were identified correctly. If the observation period is divided into the years 1975 to 1979 and 1980 to 1982, there is a striking rate of increase in the number of antenatal ultrasonographic diagnoses which were correct, from 71% in the first period to 86% between 1980 and 1982. Most of the false-negative ultrasonographic findings were congenital cardiac abnormalities, since up to that point no special fetal echocardiographic examinations had been performed. In the entire period covered by the investigation there was only one false-positive finding ("Potter's syndrome"). Forty-six per cent of the ultrasonographically demonstrated severe fetal malformations were diagnosed before the end of the 24th week of pregnancy, and 54% after the end of the 24th week of pregnancy. Only in 60 out of 141 cases (43%) with severe fetal malformations was the quantity of amniotic fluid found to be normal; 26% of the cases had hydramnios and 31% oligohydramnios. Pathologic movement behaviour had been registered ultrasonographically in 43% of the cases with severe fetal malformations; biometric dimensions of the biparietal cranial diameter and the transverse diameter of the thorax (greater than 10th percentile to 90th percentile, according to the percentile growth curves of Schmidt, 1982) corresponding to gestational age had only been measured in 30% and 50%, respectively, of the cases with fetal malformations. During the entire period covered by the investigation, from 1975 to 1982, only 16 children born at term (between the 38th and 42nd weeks) had severe malformations which had not already been diagnosed.(ABSTRACT TRUNCATED AT 400 WORDS)

Amniotic Fluid↗
PubMed1984

[What is new in plastic surgery of the head and neck for the practicing otorhinolaryngologist?].

On examples the plastic facial surgery is shown as an multidisciplinary territory, whereby main points are set. Most important for the oto-rhino-laryngology is the ear and nose correction as whereas the possibility to use collagen injections, the problems of secondary Rhinoplastics, the esthetic corrections in the area of the throat and head (dermabrasio, eye lid corrections, face lifting, hair transplantation) and considerations about education and advanced training. The maxillo facial surgery puts out the dento-alveolic dysgnathies, the ophthalmology the eye lid corrections. The experimental surgery can contribute to the still open questions, whether in the future in plastic operations allogene transplantates can fill the place of autogenous material or not.

Collagen↗
PubMed1983

Morphological feedback effect on the nucleoli of the neurons in the nucleus arcuatus (infundibularis) to hypophyseal hypogonadism in juvenile haemochromatosis.

Case report of a man of 22 with juvenile haemochromatosis and hypogonadotropic hypogonadism. There is evidence of siderosis of the basophil cells of the hypophysis, atrophy of the testicles with disappearance of leydig cells and alterations in the nucleoli of the neurones with enlargement, vacuolation and multiplication limited to the nucleus arcuatus tuberis. The nucleolar changes in this hypothalamic centre are interpreted as a feedback effect. They are comparable to matching alterations in the hypertrophy of the nucleus subventricularis (Sheehan and Kovács 1966) in post-partum hypopituitarism.

Adult↗
PubMed1983

Application of an indirect carbon immunoassay (CIA) for the rapid diagnosis of antibody to Toxoplasma gondii in sheep.

Carbon immunoassay (CIA), a novel indirect rapid test for Toxoplasma antibody in sheep, was compared with indirect fluorescent antibody assay (IFA). CIA relies on the adherence of carbon particles of India-ink to rabbit immunoglobulin G.l Carbon labelled anti-sheep rabbit IgG was used for the detection of sheep antibody when attached to tachyzoites of Toxoplasma gondii. The result was read in an ordinary light microscope and there was a clearcut difference between negative and positive reactions. Out of a total of 97 sheep sera tested, 15 sera were negative in both tests and 12 were negative in CIA but showed low positive titres in IFA. The remaining 70 sera were positive in both tests but the titres were usually about 3 dilution steps lower when investigated with CIA as compared to IFA.

Animals↗
PubMed1983

Viral glycoproteins at different stages of intracellular transport can be distinguished using monoclonal antibodies.

Monoclonal antibodies were raised against Semliki Forest virus (SFV) and all were found to recognize the E2 spike glycoprotein. The hybridomas were screened by immunofluorescence microscopy of infected cells to look for antibodies recognizing E2 at different stages of intracellular transport and two (9AB4 and 9AD6) were chosen for further study. Immunocytochemical studies at the light and electron microscopic levels were used to show that 9AB4 recognized E2 at all stages of its transport from the rough endoplasmic reticulum (ER), where it was synthesized, to the cell surface via the smooth ER and Golgi complex. In contrast, 9AD6 only recognized E2 once it had left the ER and entered the stacks of flattened Golgi cisternae. Binding of 9AD6 to E2 did not appear to be the result of the changes in oligosaccharide structure that occur in the Golgi complex and the precise modification detected by 9AD6 remains to be elucidated. A later modification, the cleavage of precursor E2 (p62) to give mature E2, was used to show that 9AD6 bound the latter more tightly than the former, whereas 9AB4 bound both with equal affinity. These results show that monoclonal antibodies might be useful when searching for new modifications to proteins undergoing intracellular transport.

Animals↗
PubMed1983

[Correction of the auricle].

The correction of protruding ears using a modification of Becker's method is described. The reconstruction of the auricle is done in stages using autologous composite grafts and rib cartilage.

Adolescent↗
PubMed1982

[Artificial bone (tricalcium phosphate) in facial surgery (author's transl)].

In recent years, the medical profession has shown increased interest in using ceramics in the field of head and neck surgery. Among the materials available, artificial bone (tricalcium phosphate) is being used more and more frequently in plastic surgery of the face on account of the good biocompatibility and bioactivity. We have been using this material in 194 patients for the last 3 years for augmentation of facial defects without experiencing any noticeable complications. This paper describes the various possible uses of artificial bones in facial surgery. Nevertheless, several further years of close observation will be necessary.

Calcium Phosphates↗
PubMed1980

Reconstruction of the tear duct system.

A new procedure for the reconstruction of the tear duct system is advocated. After partial ethmoidectomy and incising the conjunctiva at the inner canthus, a superiorly based flap is secured from the septum and pulled into the defect; then it is secured by 7--0 sutures. This flap contains mucous membrane and cartilage.

Humans↗