Search PubMed⌕ Search

Biomedical subjects

C Wagenknecht

Publications and source records attributed to C Wagenknecht.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Liver diagnostics].

Prerequisite of a scientific and rational liver diagnostics is the knowledge of the physician of function and structure of the liver. The laboratory demand should always be an accomplishment of the physician and should be performed only upon such a scale that it is also followed by therapeutic consequences and/or consequences concerning the expert's opinion. The biochemical blood analysis gives information about the size of the injury to the parenchyma and about the disturbance of the various partial functions of the liver. In this case is to be taken into consideration that biochemical and histological parameters are no concurrent, but supplementing diagnostic methods. A progress in liver diagnostics is the use of the isoenzymes of the aspartate aminotransferase and the lactate dehydrogenase as well as of the enzymes of the metabolism of the connective tissue. With the entering into selected parameters of the liver diagnostics possibilities to the establishment of the disturbed liver metabolism by means of markers are shown and at the same time recommendations for the praxis of the liver diagnostics are derived.

Clinical Enzyme Tests↗
PubMed1985

[Recommendations for the training of specialty candidates in internal medicine in laboratories].

A full-time visit for several weeks of candidates of specialists of internal medicine in laboratories, in which competent specialists of clinical chemistry are working, contributes to the improvement of the interdisciplinary cooperation. By recognition of the pre- and post-analytic errors and by the scientifically proved indication on the basis of diagnostic strategies as well as an effective interpretation the effectiveness of the laboratory diagnostics in the process of medical care can be increased. Practical abilities ready for use are particularly demanded for bed-side methods and in the fields of haematology and haemostaseology.

Blood Chemical Analysis↗
PubMed1985

Isoenzymes in plasma of acute leukaemia patients: prevention of anthracycline cardiomyopathy.

During the diagnosis and subsequent monitoring of patients with acute leukaemia, and of those with terminal blastic crisis in chronic myelogenous leukaemia, the activity of total LDH, ALAT, AP, ASAT as well as the isoenzymes LDH-H, LDH-M were measured in the plasma. Enzyme and isoenzyme activity of LDH, which differed in quantity at the various times of measurement, reflected the varying proliferation rate, depending upon the individual and upon the time of measurement and, consequently, the tumour cell mass.

Adult↗
PubMed1984

Improved protection in myocardial ischemia by combined prostacyclin administration and intraaortic balloon pumping.

The influence of prostacyclin (PGI2) alone or in combination with intraaortic balloon pumping (IABP) on the levels of energy-rich phosphate compounds was investigated before and after coronary artery ligation in canine myocardium. There was a higher level in creatine phosphate in the ischemic as well as non-ischemic areas of the myocardium after treatment with PGI2, however the most protective effect was registered after a combination of PGI2 and IABP. PGI2 also reduces the release of cathepsin D activity into the blood independently whether or not a mechanical support of the heart after coronary artery ligation was performed.

Animals↗
PubMed1983

[Diagnosis of acute hepatitis].

The following recommendations are to be given for the basis diagnosis of hepatitis: --In the blood donation and blood transfusion institutions the control of the donors is performed by means of the combination ALAT and HBs-antigen (transmigration electrophoresis); depending on methods limits were established showing a high diagnostic specificity. Thus, no doubt, the diagnostic sensitivity is decreased, but the number of the examined persons with falsely positive findings probably diminishes. --For the diagnostics in the clinic the parameters ALAT, ASAT, bilirubin and the thymol turbidity test are at the disposal as criteria of the liver cell damage as well as AP (alkaline phosphatase), AAP and GGT as criteria of the cholostasis and the thymol turbidity test, serum protein including immunoglobulins as criteria of the mesenchymal reaction. The reference areas must be established method-specifically corresponding to the interrogation of the physician. --The isoenzymes of the ALD, the ASAT and the LDH represent an essential enrichment of the diagnostic and prognostic estimation of hepatitis. But at present it is not yet possible to determine these parameters in routine work. However, there gradual introduction into practice should be the aim.

Acute Disease↗
PubMed1982

[Anthracyclin-cardiomyopathy (author's transl)].

Doxorubicin is one of the most effective antineoplastic drugs in clinical practice. Its clinical usefulness extends from acute leucemia and lymphoma to a wide range of solid tumors. However, the use of this drug is limited by its cardiac toxicity, that is often life-threatening. A number of clinical approaches discussed in this paper have been used to circumvent the problem of doxorubicin-induced congestive heart failure. A summarizing survey of the literature has led to establish two principles for prevention of doxorubicin-induced congestive heart failure with clinical meaning in the moment: --the way of administration --the clinical use of Ca-antagonist. The two principles provide an objective basis for preventation of congestive heart failure. The pathobiochemical background, analysed in this paper in detail, demonstrates that the same metabolic condition exist in the myocardial cell as in red blood cell. These interactions are the basis for a further analysis of metabolism in the cell, especially the redox metabolism of glutathione.

Animals↗
PubMed1982

[Amino acid imbalances in blood of pregnant women with diabetes and in blood of their newborns--limit values for screening (author's transl)].

Blood-borne free amino acids of 100 mothers were tested immediately after birth. Fifty of the probands had diabetes, while the other 50 were metabolically intact. Amino acid imbalance was recorded by means of multidimensional variance analysis from the diabetics and found to have been largely associated with glutamic acid threonine, alanine, glycine-serine, and glutamine.--A formula, derived from the aforementioned relevant amino acid concentrations, is given in this paper together with a nomogram (which might be used instead of the formula) for determination of diabetes-caused alterations in the amino acid spectrum

Amino Acids↗