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Biomedical subjects

C W Walter

Publications and source records attributed to C W Walter.

53 records · Page 3Linked to original sources
PubMedDate not supplied

A novel cancer therapy using a Mössbauer-isotope compound.

Cancer radiotherapy uses high doses of ionizing radiation (1-10(2) Gy; 10(2)-10(4) rad) because only a small fraction of the absorbed dose leads to lethal double-strand breaks in DNA. These breaks are more efficiently produced by Auger electrons (1-10 eV nm-1) generated in proximity to the DNA. The energy of these electrons (on average 21 electrons for the decay of 125I) is dissipated within 10-100 nm of the Auger event and produces multiple double-strand DNA breaks. A single Auger event can be lethal to a cell and is comparable to more than 10(5) photon absorption events in conventional radiotherapy. We now report that 57Fe(III).bleomycin, administered to malignant cells in vitro and in vivo and irradiated with resonant Mössbauer gamma rays (14.4 keV), causes ablation of the malignant cells, presumably by Auger cascade, with extremely small radiation doses--about 10(-5) Gy. As a basis for comparison, about 5 Gy is necessary to achieve a similar effect with conventional radiotherapy.

Adenocarcinoma↗
PubMedDate not supplied

Finding a better way.

Explore the source record for details and available documents.

Blood Transfusion↗
PubMedDate not supplied

An automatic cardiac resuscitator for emergency treatment of cardiac arrest.

A new, portable, automatic resuscitator seeks respiratory signals and electrocardiogram of a victim in cardiac arrest through an intrapharyngeal sensor and a lingual-epigastric skin pathway. The resuscitator then assesses the status of the patient and delivers either an electric impulse to defibrillate or a pacing pulse, as indicated by an algorithmic logic circuit gated by respiratory rate and ECG. Field testing the device on 21 patients in ventricular fibrillation resulted in 35 successful conversions to sinus rhythm and 1 long-term survivor. Pacing was accomplished in two humans. Such a device has great potential for saving lives by eliminating crucial time now spent waiting for skilled help and equipment to arrive.

Animals↗
PubMedDate not supplied

Microwave thawing of frozen parenteral solutions.

A commercially available microwave oven modified for use at medication stations throughout hospitals allows timely thawing of frozen parenteral solutions. The inherent problems of safety and uniform heating have been overcome, thus making possible the preparation, storage, and distribution of admixtures on a regional basis and ensuring the integrity of the product. Most parenteral medications are not degraded by microwave energy, and thawing by microwave energy permits timely administration and allows coordination of medication for a series of patients.

Equipment and Supplies, Hospital↗
PubMedDate not supplied

The surgeon's responsibility for asepsis.

Eighty percent of postoperative wound infections result from bacteria acquired elsewhere than in the operating room. Concomitant infections--such as dermatitis; periodontitis; infections of the respiratory, gastrointestinal, or urinary tracts--are not identified preoperatively, despite a threat to the patient greater than that of anesthesia and surgery combined. Isolation of overt infection is neglected. The entire hospital becomes a reservoir of bacterial debris that is reflected in the carriage of pathogens by personnel and patients. Infections are often initiated by medical devices that invade the vascular system, respiratory tract, or urinary bladder. Professional leadership at the bedside is the key to detecting and correcting breaches in technique and setting an example of a philosophy of total patient care.

Antisepsis↗