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Biomedical subjects

C W Schmidt

Publications and source records attributed to C W Schmidt.

At least 19 recordsLinked to original sources

Antisocial behavior of intravenous drug abusers: implications for diagnosis of antisocial personality disorder.

OBJECTIVE: A pattern of chronic adult antisocial behavior is not sufficient for the DSM-III-R diagnosis of antisocial personality disorder unless the early-onset criteria are satisfied, even if the adult criteria are met. The utility of the early-onset requirement for the diagnosis was examined in intravenous drug abusers, a population known to have high rates of irresponsible, aggressive, and criminal behavior. METHOD: The subjects were 237 drug abusers who had volunteered for an outpatient study of psychopathology and HIV risk behavior and infection. They completed a structured psychiatric interview as part of their participation in that study. The adult antisocial behavior of the group that met both the early-onset and the adult criteria for antisocial personality disorder, the group that met only the adult criteria, and the group that met neither the early-onset nor the adult criteria was then compared. RESULTS: Antisocial personality disorder (meeting the early-onset and adult criteria) was diagnosed in 44% of the sample; an additional 24% met only the adult criteria. The group with the diagnosis of antisocial personality disorder reported a more pervasive and more serious pattern of adult antisocial behavior than did the other groups, although antisocial behavior was commonplace in all three groups. CONCLUSIONS: Early onset of multiple antisocial behaviors identified a subset of drug abusers with important differences in the extent and severity of their adult antisocial behavior. The antisocial behavior of the group that met only the adult criteria suggests the possibility of a late-onset and less severe form of antisocial personality disorder.

Age Factors

Personality and sexual functioning of transvestitic fetishists and other paraphilics.

Utilizing the NEO Personality Inventory (NEO-PI) and the Derogatis Sexual Functioning Inventory (DSFI), 24 transvestitic fetishists (TVs) were compared with a similar clinic-evaluated group of 26 other paraphilics (OPs). The data replicated previous results and extended them by showing that TVs did not differ from OPs on most dimensions of the NEO-PI and the DSFI. Both groups were significantly higher on neuroticism and significantly lower on agreeableness than the NEO-PI male normative population. The other paraphilic group tended to score lower on conscientiousness than the TVs and the normative comparison group. For nine of the 10 DSFI variables, there were no significant differences between the TVs and the OPs. The TVs were significantly higher than the OPs on role identity, indicating a more feminine identification. Both the TVs and OPs reported elevated levels of fantasy. The implications of these findings suggest that, in general, TVs and OPs are more similar than they are different, with a common personality profile and a similar pattern of sexual functioning.

Adult

A comparison of five-factor personality dimensions in males with sexual dysfunction and males with paraphilia.

We compared personality profiles of men with sexual dysfunction (n = 51) to those of age-matched men with a primary diagnosis of paraphilia (n = 51) employing the NEO Personality Inventory (NEO-PI), a measure of the five-factor model. Preliminary analyses in a large sample of patients in a sexual behaviors consultation unit supported the reliability and factorial validity of the NEO-PI for this population. Analysis of variance showed significant differences between the dysfunctional and the paraphilic groups on two of the five NEO-PI domains, Neuroticism (N) and Agreeableness (A). The group personality profile of the sexually dysfunctional men was comparable to the normative sample of the NEO-PI, except for a slight elevation in N. By contrast, men with paraphilia had a personality profile marked by high N, low A, and low Conscientiousness (C). Treatment implications of the average personality profile of the sexual dysfunction group and the distinctive personality profile of paraphilic men are discussed.

Adult

[Pseudofluorosis: psychologic aspects of environmental pollution].

A middle-aged woman who had been living in close surroundings of a fluorine-emitting factory for many years, was examined because she claimed to be suffering from skeletal fluorosis. Radiological, histological and laboratory findings did not give evidence of fluorosis. Fluoride concentrations were normal in samples of blood, bone, pooled urine, nails and hair. Even this proof to the contrary did not shake her conviction of many years that she was suffering from fluorosis. Thus, psychological aspects have to be considered in the assessment of health implications of pollutants.

Bone Diseases

Intravenous drug abusers with antisocial personality disorder: increased HIV risk behavior.

Intravenous drug abuse is strongly associated with HIV transmission and with having a diagnosis of Antisocial Personality Disorder (ASPD). While the co-occurrence of intravenous drug abuse and ASPD is related to poor drug abuse treatment outcome, little is known about the contribution of ASPD to the intravenous drug abusers (IVDAs) level of HIV risk. The present study related the diagnosis of ASPD with specific drug use behaviors associated with high risk of HIV transmission. Subjects (N = 100) were intravenous drug abusers who volunteered for an HIV risk assessment study. Subjects with ASPD reported significantly higher rates of injection-equipment sharing and shared with significantly more people than IVDAs without ASPD.

Adult

The value of MLA 144 culture fluid for the isolation of human immunodeficiency virus.

Human immunodeficiency virus (HIV) was readily isolated by co-cultivation of patients' cells with phytohaemagglutinin-stimulated mononuclear cells from umbilical cord blood in 2 ml cultures in 24-well plates. Fluids from cultures of the MLA 144 cell line acted as an excellent source of interleukin-2, and promoted early replication of HIV in the primary cultures. Reverse transcriptase activity was commonly present at significant levels by 4-7 days. In contrast, recombinant IL-2 (recIL-2) did not promote early replication under these conditions. Adequate washing of the phytohaemagglutinin blasts was critical in this system, although others have reported it to be less important under other culture conditions. Cell concentrations and HIV: target cell ratios appeared not to play a major role in early outgrowth of virus. The particular sheep anti-alpha interferon tested resulted in a two-fold reduction in RT activity. Virus was readily transmitted in this simplified cheaper culture system.

Cell Line

Expanding psychiatric service in a hospital emergency room.

Senior medical residents were used to extend psychiatric coverage in a busy hospital emergency room. Their service was supported by the backup consultation of senior psychiatric physicians. The medical residents worked in conjunction with psychiatric residents to provide 24-hour daily emergency psychiatric service to more than 350 patients during a 12-month period. There were no significant differences in the demographic composition of the patient population seen or in the disposition of individual patients made between the medical and psychiatric residents. The hospital was able to expand its psychiatric service in the emergency room without major increases in cost. The medical residents benefited by experiencing a more diversified patient care training program, and they earned a modest supplement to their houser officer salary.

Adult

[Frequency of bone fractures in chronic fluoride exposure].

In order to establish the frequency of bone fractures in 2 population groups with increased and decreased fluor exposition, respectively, the case histories of a surgical ward for men were evaluated. Of 10 age groups ten times a lower percental frequency of fractures in combination with an increased presence of fluor was found. Fluorides have got an increasing significance for the prophylaxis of fractures in the treatment of osteoporosis.

Fluorides

[Bone fluorosis without occupational exposure in chronic renal insufficiency].

Report on a 70-year-old male with bone fluorosis which was ascertained radiologically, by section and fluor analysis in the bone ash. With empty professional anamnesis as cause was found the presence of a chronic renal insufficiency with simultaneously increased fluor content of drinking water. The decreased renal excretion of fluoride might have led to the pathological development in the bones. It is referred to the significance of extra-medical fluor load and the knowledge of the renal function when halogen is therapeutically used.

Aged

Biorhythms and highway crashes. Are they related?

Biorhythm, a theory that purports to identify periods of increased individual susceptibility to accident or misfortune on the basis of recurring biological cycles, is currently enjoying world-wide popularity. In view of the implications of such a theory for both public health and safety, the present study was undertaken as an empirical test of its validity. Using data from 205 carefully investigated highway crashes (135 fatal; 70 nonfatal) in which the drivers were clearly at fault, the authors computed specific points in drivers' biorhythm cycles at which the accidents occurred. The observed frequencies of accidents occurring during so-called critical and minus periods were then compared with the frequencies to be expected on a chance basis alone. The results provided no evidence for a relationship between purported biorhythm cycles and accident likelihood.

Accidents, Traffic

Suicide by vehicular crash.

The authors evaluated data on 182 fatally injured and 96 nonfatally injured drivers involved in vehicular crashes over a 6-year period. Only 1.7% of the total fatal crashes were considered to have been suicides, and 1% of the nonfatal crashes were deemed suicide attempts. Neither group of drivers had unusually high incidences of previous suicidal ideation or behavior, but both groups tended to be socially deviant, with above average levels of psychopathology and social aggressiveness. Crash victims in both groups also had poor driving records and high rates of alcohol abuse, findings that have important implications for accident prevention.

Accidents, Traffic