Search PubMed⌕ Search

Biomedical subjects

C W Lewis

Publications and source records attributed to C W Lewis.

83 records · Page 5Linked to original sources
PubMed1965

Effect of oleic acid on growth and cell structure of mycobacteria.

Schaefer, Werner B. (National Jewish Hospital, Denver, Colo.), and C. Willard Lewis, Jr. Effect of oleic acid on growth and cell structure of mycobacteria. J. Bacteriol. 90:1438-1447. 1965.-The growth-stimulatory effect of fatty acids on Mycobacterium kansasii and other mycobacterial species is associated with transient changes in the morphology of the bacteria. One change observed is the appearance of intracellular vacuoles separated by chromatinic crossbars. Evidence is presented that these changes are due to the rapid metabolic uptake and the accumulation of lipid in the form of globules. This process provides the cells with an internal reservoir of a preferred carbon and energy source. In certain mycobacterial species, including M. kansasii, the morphological changes are elicited by free and by esterified fatty acid; in others, only by free fatty acid. The latter strains apparently lack the enzyme to split the fatty acid ester.

Fatty Acids↗
PubMedDate not supplied

Assessment of the Frank-Starling relationship by two-dimensional echocardiography.

The Frank-Starling relationship between left ventricular stroke work and end-diastolic minor-axis cross-sectional area was evaluated as a load-insensitive measure of inotropic state by two-dimensional echocardiography in 10 conscious dogs. Stroke work was calculated as the product of systolic change in cross-sectional area and either (1) beat-to-beat mean arterial pressure or (2) initial systolic blood pressure. Both Frank-Starling relationships were highly linear during preload variation (mean r = 0.96), sensitive to the inotropic state (slope increase with calcium 51% +/- 43% and 62% +/- 53%, respectively), and insensitive to afterload (r < 0.4, slope or x intercept versus afterload). Thus the Frank-Starling relationships derived from two-dimensional echocardiographic images and peripheral arterial pressure may be a useful and practical means of assessing inotropic state with minimally invasive measurements.

Animals↗