Biomedical subjects
Publications and source records attributed to C W Kim.
Frozen section diagnosis is a highly useful method of diagnosis. There were 4434 frozen sections, 24 false positive diagnosis, 65 false negative diagnosis and 30 deferred diagnosis. This method achieves the highest accuracy when there is a cooperation between experienced surgeon and reliable and careful pathologist. It is wise to defer the diagnosis of consult to other pathologist in difficult situation.
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We induced experimental renal arterial embolization with the radiopaque solution of ethanol and iodized oil (Lipiodol) in 35 rabbits to evaluate the capability of the mixture to induce renal ablation. Serial renal angiography and plain abdominal radiography were performed immediately, one week and two weeks after embolization. Neither pure Lipiodol nor a 50% ethanol solution caused renal embolization. However, infusion of 50% and 75% ethanol-Lipiodol solutions resulted in embolization equal to that caused by absolute ethanol. The 50% ethanol-Lipiodol solution was so radiopaque that we could easily observe the embolization process during fluoroscopy. Renal arterial embolization with the 50% ethanol-Lipiodol solution was successful in three patients with hypernephroma. Our results suggest that a 50% ethanol-Lipiodol solution is radiopaque and an effective agent for renal arterial embolization.
Sonographic findings of obstruction of the inferior vena cava (IVC) in 14 cases are described and correlated with venographic findings. The causes of the obstruction were membrane (five cases), thrombosis (three), and intraluminal tumor invasion by hypernephroma, hepatoma, and adrenal carcinoma in six. Sonographic examination revealed highly echogenic segmental obliteration or membrane in membranous obstruction and echogenic intraluminal mass in thrombotic occlusion. Absence of an identifiable patent lumen in a technically satisfactory study was another finding in thrombotic obstruction. On real-time sonograms, the normal respiratory changes of the IVC were absent when there was complete occlusion. Transhepatic collaterals, patency of other segments of the IVC, and associated malignancy were additional sonographic findings. Comparison to venography suggested that in addition to ease and safety, sonography has advantages in delineation of the cephalad extent of occlusion, dynamic evaluation of the IVC below the obstruction, and the simultaneous evaluation of adjacent organs.
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A 28-month-old Korean girl developed a rapidly progressive disease, characterized by disturbance of consciousness, tremor, nystagmus, ophthalmoplegia, irregular deep respiration and vomiting. The patient succumbed 2 weeks after the onset of the illness. CT scan disclosed bilaterally symmetrical, low density lesions in the white matter and lateral basal ganglia. Distinctive histopathological findings at postmortem included spongiotic necrosis of the neuropil, marked capillary vascularity, persistence of relatively normal neurons in severely damaged zones, and comparatively little astrocytosis. The bilaterally symmetrical distribution of these changes in the putamen and periaqueductal gray matter of the midbrain were compatible with Leigh's disease.
Amino acid preparations for intravenous infusion are indispensable materials in parenteral nutrition. We have surveyed the progress and problems related to such preparations. In recent years, the necessity of various amino acid preparations suitable for different morbid state and/or ages has been the subject of much interest. In practice, several new amino acid preparations for specific uses have been proposed.
The surface morphology of larval and adult Trichinella spiralis was studied by scanning electron microsocopy (SEM) of fixed, dried, and metal-coated specimens. The results are compared with those found earlier by various investigators using light and transmission electron microscopy. Some morphological features reported here are revealed uniquely by SEM. These include the pores of the cephalic sense organs, the character of secondary cuticular folds, variations of the hypodermal gland cell openings or pores, and the presence of particles on the copulatory bell.
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The Concanavalin A (Con A) stimulation response of peripheral lymphocytes in vitro was found to be decreased statistically significant (alpha = 0.005) in patients with light atopic dermatitis, Strictly matched pairs were examined. Using ten graded concentrations of Con A, dose-response relations of the pairs were demonstrated, differences were more evident at lower suboptimal concentrations. Background DNA-synthesis of the patients was elevated.
Urinary outputs of amino acids in nine patients receiving intravenous hyperalimentation were estimated for evaluating adequacy of dosage and composition of the infusage for the maintenance of normal metabolism of tissue proteins in the subjects. The daily outputs of the methylated amino acids (3-methylhistidine, epsilon-N-methylated lysines and guanidino-N-methylated arginines), which are thought to be derived from tissue proteins, remained in the normal ranges, suggesting that the normal metabolism of tissue proteins was sustained during intravenous hyperalimentation. Relatively large urinary excretion of threonine, serine and glycine might reflect the large dosage of glucose in the infusate and disuse of these amino acids during the treatment, especially in the patients with hepatic dysfunction. Diurnal rhythms in urinary outputs of amino acids in patients receiving intravenous hyperalimentation were not observed, except for the outputs of threonine, serine and glycine, which were large during the 3.00-9.00 h and 15.00-21.00 h periods. The absence of daily fluctuations of the methylated amino acids in urine suggested that there were no diurnal rhythms in the metabolism of tissue proteins in the subjects.
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In spite of the non-specific mitogenic effect of nickel salts, 3H-thymidine uptake ration (TUR) of nickel-stimulated lymphocyte cultures in nickel-sensitive atopic dermatitis patients and in non-atopic nickel-sensitive patients was significantly higher at 10 mug per ml concentration of nickel salts than in nickel non sensitive subjects (P less than 0.001). A significant difference was also demonstrated at concentrations of nickel salts of 40 mug per ml. The TUR value of nickel-stimulated cultures in nickel-sensitive atopic dermatitis patients tended to decrease in comparison to non-atopic nickel-sensitive patients. Furthermore, the TUR of phytohemagglutinin-p (PHA) stimulated cultures was also lower in atopic dermatitis patients than in non-atopic subjects.
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