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Biomedical subjects

C W Janssen

Publications and source records attributed to C W Janssen.

At least 37 records · Page 2Linked to original sources
PubMed1987

Immunoglobulins, complement and carcinoembryonic antigen in patients with gastric carcinoma.

Immunoglobulins, complement components, carcinoembryonic antigen and erythrocyte sedimentation rate were quantified in patients with gastric carcinoma preoperatively and during follow-up. At the time of diagnosis the individual patient with gastric carcinoma may be given a score that predicts the extent of his disease and his prognosis. In the disease-free period after potentially curative surgery a patient can be grouped according to whether he belongs to those with a fair prognosis or a poor prognosis. Serial testing postoperatively may corroborate the clinical interpretation of the initial signs of recurrence. The methods are simple and the variables are obtainable from a sample of blood in a routine immunological laboratory at low cost.

Blood Sedimentation↗
PubMed1987

Serum concentrations of immunoglobulins and complement components in patients with recurrence after resection of gastric carcinoma.

Immunoglobulins and complement components were quantitated in sera sampled at 3-6-month intervals from 20 patients with recurrence after resection of gastric carcinoma stages I-III (pTNM). Concentrations of IgA, C3, C4, and C1-INH at clinical recurrence were increased in a significant number of patients as compared to the concentrations 3-6 months prior to recurrence. The mean concentration of C3, C4, and C1-INH were higher than prior to recurrence. At the time of recurrence, the concentrations of C3, C4, and C1-INH were higher than the corresponding postoperative concentrations among 14 patients alive and disease-free for 5 years or more. Three to six months prior to recurrence, the concentrations of C4 and C1-INH were also higher than those of the 5-year survivors. The data indicate that serial quantitation of immunoglobulins and complement components may beof value in the follow-up after resection of gastric carcinoma.

Aged↗
PubMed1987

Concentrations of serum proteins and erythrocyte sedimentation rate in patients with different histological types of gastric carcinoma.

ESR and serum concentrations of IgG, IgA, IgM, C3, C4, C1-INH and CEA were quantified preoperatively in 195 patients with gastric carcinoma. The values were grouped according to the extent of disease (T1-3N0M0, T2-3N + M0, T4AnyNM0, AnyTAnyNM1) and according to the histological type of tumor (intestinal-type, diffuse and unclassifiable). The data were analysed using a two-way analysis of variance with unequal cell sizes. ESR, C4, C1-INH, IgG and CEA varied with the extent of disease. When the data were adjusted for this variation, we found that the values of ESR, C4 and CEA were different between the various histological types. The values were highest in patients with the intestinal-type tumor and lowest in those with diffuse tumor. The concentrations of IgG and C1-INH were not different between the histological types. Our results are relevant when ESR, C4 and CEA are used in the evaluation of patients with gastric carcinoma.

Blood Proteins↗
PubMed1987

Preoperative prediction of extent and prognosis of gastric carcinoma by four serum proteins and erythrocyte sedimentation rate.

In 195 patients with gastric carcinoma the preoperative ESR and serum concentrations of IgG, C4, C1-INH and CEA varied significantly with the extent of disease. Extent of disease and prognosis were predicted from these variables by discriminant analysis. The discriminant rules were tested on the same patients in an unbiased way. Metastases or no metastases were correctly predicted in 75% of the patients. By an appropriate prior distribution 93% of the patients without metastases were identified. The disease extent was also predicted in subgroups of patients with and without metastases. Survival was correctly predicted preoperatively in 66% of the patients and 83% of the patients with a fair prognosis were identified. Of the patients preoperatively allocated to the non-survival group 94% did actually die during follow-up. When used in addition to other available information, our discriminant rules will contribute to the quality of the preoperative evaluation of patients with gastric carcinoma.

Adult↗
PubMed1986

Carcinoembryonic antigen in patients with gastric carcinoma.

Carcinoembryonic antigen (CEA) was quantified pre- and post-operatively in plasma from 171 patients with gastric carcinoma. The pre-operative plasma concentration was above the normal reference value (3.5 micrograms/l) in 18% of the patients in stage I-III (pTNM) and in 57% of the patients in stage IV. Pre-operative concentrations above 10 micrograms/l indicated metastatic or inoperable disease. The concentrations were not different between the stages I, II and III. However, the pre-operative CEA concentrations were related to survival after potentially curative resection. At recurrence most of the patients had markedly increased CEA, often with increasing CEA in the months before clinical recurrence. Most of the patients clinically disease-free at the end of the follow-up period had a transitory or prolonged post-operative elevation of CEA. This made the post-operative evaluation of CEA difficult. Serial determination of CEA in the follow-up of gastric cancer patients therefore had little or no clinical value, whereas the pre-treatment levels were of clinical significance.

Adult↗
PubMed1985

The prognostic value of preoperative serum immunoglobulin and complement component concentrations in patients with gastric carcinoma.

Patients with and without recurrence of gastric carcinoma after potentially curative resection (stages I, II and III--pTNM) were studied. The preoperative serum concentrations of IgG and C1-INH were significantly different in a group of 22 patients with recurrence and a group of 33 survivors who were free from recurrence. The patients with recurrence had lower concentrations of IgG (8.3 +/- 2.6 g/l) and higher concentrations of C1-INH (0.4 +/- 0.07 g/l) than the recurrence-free survivors (10.8 +/- 3.5 and 0.35 +/- 0.08 g/l, respectively). The results indicate that preoperative quantitation of serum immunoglobulins and complement components may be helpful in predicting the prognosis in gastric carcinoma.

Aged↗
PubMed1985

The prognostic value of postoperative serum immunoglobulin and complement component concentrations following gastric resection for carcinoma.

Patients clinically free from disease after potentially curative resection of gastric carcinoma, stages I, II and III (pTNM) were studied. The concentrations of immunoglobulins and complement components were quantified at 3-month intervals during the first year after surgery. The values in the individual patients showed no systematic variation with time while there was no clinical evidence of disease. The mean concentrations of C4 and C1-INH, however, were higher in 22 patients with later recurrence (0.43 +/- 0.10 and 0.43 +/- 0.07 g/l, respectively) than in 34 patients who were alive and disease-free at follow-up (0.36 +/- 0.07 and 0.36 +/- 0.04 g/l). The mean serum concentrations of IgG, IgA, IgM and C3 showed no intergroup difference. High levels of C4 and C1-INH postoperatively apparently indicate that the patient still harbours malignant disease with poor prognosis.

Adult↗
PubMed1983

Stage-related correlations between immunoglobulins and complement components in preoperative sera from patients with gastric carcinoma.

Immunoglobulins A, G and M and complement components C3, C4 and C1-INH were quantitated in sera taken preoperatively from 168 patients with gastric carcinoma. The values were grouped according to stages (pTNM). The concentrations of C4 and C1-INH increased with advancing stage of disease and were above normal mean values in all stages. The concentration of IgG was below the normal mean value among all the patients and with the lowest concentration in stage III. Concentrations of IgA and C3 were above normal means but without significant relation to stages. There was a positive correlation between the concentrations of IgG and C1-INH in sera from patients with stage IV carcinoma, while the same correlation was negative in stages I-III. Although the results varied among the patients within each stage, the profiles of immunoglobulin and complement concentrations are of value in the preoperative staging of the disease.

Adult↗