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Biomedical subjects

C W Dingman

Publications and source records attributed to C W Dingman.

30 records · Page 2Linked to original sources
PubMed1968

Estrogen-dependent increase in transfer RNA during differentiation of the chick oviduct.

Estrogenic hormones induce morphologic and biochemical differentiation in the oviduct of the immature chick. Concomitant with the hormone-stimulated tissue growth, there was an increase in 4S RNA, as judged by polyacrylamide-gel electrophoresis, and a corresponding increase in cellular transfer RNA activity, as measured by the amino acid acceptor capacity. This system may be suitable for studying the relation of hormones to transfer RNA in a differentiating tissue.

Amino Acids↗
PubMed1966

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

Aflatoxins↗
PubMed1965

Actinomycin D and Hydrocortisone: intracellular binding in rat liver.

DNA was found to be the major intracellular binding site for labeled actinomycin D administered in vivo. In analogous studies, hydrocortisone did not bind to nuclear structures. Furthermore, following the administration of actinomycin D, a highly positive correlation was found between the RNA content of the nucleus and the ability of the nucleus to synthesize RNA.

Animals↗