Biomedical subjects

C W Chow

Publications and source records attributed to C W Chow.

148 records · Page 9Linked to original sources

PubMedDate not supplied

Pes anserinus syndrome due to solitary tibial spurs and osteochondromas.

We studied 19 children with the pes anserinus syndrome due to proximal tibial exostoses. Nine children had a solitary sessile or pedunculated osteochondroma that produced a painful lump that was readily palpable. The symptoms resolved following removal of the osteochondroma. Ten children had a bone spur that was shaped like a rose thorn. It produced pain with snapping or a feeling of locking of the pes anserinus tendons. Careful palpation was required to detect the tender bone spur beneath the pes anserinus. In five children, the bone spurs were excised because of persistent symptoms, and each was shown to be an exostosis without a cartilage cap. The symptoms resolved. However, the bone spurs need not be excised if the symptoms improve with rest and do not recur following resumption of activities.

Adolescent↗

PubMedDate not supplied

Human infection by Rhizopus azygosporus and the occurrence of azygospores in Zygomycetes.

Fungal isolates from the peritoneal cavity, kidney and liver, respectively, of three premature Australian babies are described as Rhizopus azygosporus. All three babies died. This is the first report as far as we know of the isolation of this fungus from human infections. It has previously been isolated only from Indonesian tempeh. The source of these infections was not determined. Rhizopus azygosporus is closely related to R. microsporus var. microsporus, var. rhizopodiformis and var. chinensis. The occurrence of azygospores in Zygomycetes and the taxonomic position of R. azygosporus are discussed.

Fatal Outcome↗

PubMedDate not supplied

Juvenile laryngeal papillomatosis in a pediatric population: a clinicopathologic study.

A series of 22 children with juvenile laryngeal papillomatosis treated over a 31-year period is presented. The majority of patients were diagnosed when less than 5 years of age. Two patients died from the disease and four patients still had active disease at the completion of the study period. The duration of disease and number of recurrences were extremely variable. The number of recurrences was inversely related to the age of onset. The histologic findings were very similar in all patients, and no particular histologic feature had prognostic significance. In 20 patients, laryngeal biopsies were positive for human papillomavirus (HPV) 6/11 by either in situ hybridization (17) or polymerase chain reaction (19) or both (16). The number of patients who were HPV negative was small (two); interestingly, neither case had aggressive disease. Our findings suggest that age of onset and HPV status may be of prognostic value in determining the clinical course of the disease.

Chemotherapy, Adjuvant↗

PubMedDate not supplied

Coexistent T-cell lymphoblastic lymphoma and an atypical myeloproliferative disorder associated with t(8;13)(p21;q14).

This report describes a neoplasm exhibiting both lymphoid and myeloid differentiation associated with an acquired balanced translocation between chromosomes 8 and 13 occurring in a 10-year-old boy. Serial lymph node biopsies revealed the presence of both lymphoblastic lymphoma and an atypical myeloproliferative disorder within the same node. Immunophenotyping was consistent with the presence of an immature T-cell population within the nodal biopsy specimens. Cytogenetic analysis of the bone marrow and lymph node biopsy specimens revealed a unique translocation, t(8;13) (p21;q14). Molecular analysis revealed rearrangement of the immunoglobulin heavy chain gene and germline configuration of the T-cell receptor gene. The patient had a poor response to classical T-cell acute lymphocytic leukemia/lymphoma therapy and was changed to a myeloid leukemia protocol with good response. He underwent bone marrow transplantation but died soon after of overwhelming graft-versus-host disease. We found five similar cases in the literature, suggesting the existence of a subset of mixed lymphoid/myeloid disorders with 8p;13q translocations, in which the clinical picture is dictated by the myeloid element.

Child↗