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Biomedical subjects

C W Adams

Publications and source records attributed to C W Adams.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Exchange of plasma radioactive cholesterol with atheroma lipids in situ and implanted subcutaneously.

Physicochemical exchange of radioactive cholesterol was investigated in mildly hypercholesterolaemic rabbits. Such exchange was examined in erythrocytes and atheroma lipids in situ in the aortic wall and in such lipids when implanted subcutaneously. The implanted atheroma lipids gained radioactivity from intravenously injected [3H]cholesterol, even though cholesterol was being resorbed from the implants. Autoradiography showed exchange between plasma cholesterol and both intracellular and dispersed extracellular lipid in these implants. Cholesterol crystals in both implants and atheromatous lesions labelled only sluggishly. The results are consistent with the view that physicochemical exchange is a major factor in cholesterol movement in vivo.

Animals↗
PubMedDate not supplied

Crystals in atherosclerotic lesions: real or artefact?

Atherosclerotic lesions were obtained from man during surgery and from cholesterol-fed rabbits. They were maintained at about 37 degrees C during handling. Smears were prepared on glass slides and these were examined microscopically at 37 degrees C. Solid rhomboidal or thick needle-like crystals were present at 37 degrees C but increased in numbers or in size or both on cooling. Staining studies and measurement of melting point (133-153 degrees C) suggested that such crystals are composed largely of free cholesterol or a related sterol. Liquid crystals exhibiting conic focal (Maltese cross) anisotropism were present at 37 degrees C and did not appreciably increase in either size or numbers on cooling. Staining studies and their resistance to digitonin suggested that these Maltese cross crystals are largely esterified cholesterol. Thin needle-like crystals arranged like feathers or in rosettes were seen in smears of adipose tissue and were attributed to triglycerides.

Adult↗
PubMedDate not supplied

The resorption rate of atheroma lipids in situ and implanted subcutaneously.

Resorption rates have been investigated in the rabbit for atheroma-lipids and cholesterol injected subcutaneously, atheroma lipids in situ in the mildly atheromatous aorta and lipid in the degenerating peripheral nerve. Atheroma lipids injected subcutaneously resorb relatively rapidly, subcutaneous cholesterol and lipid in Wallerian degeneration are intermediate in this respect, whereas only the group with an initially low blood cholesterol (small than approximately equal to 100 mg/100 ml) showed even a suggestion of lipid resorption from their mild or trivial atheromatous lesions. Ti is not clear whether or not atheroma resorbed at all in the groups with initial blood cholesteroles above 100 mg//00 ml. The relative inertia of the arthromatous lesion is mainly attributed to the relative absence of reticuloendothelial phagocytes in it.

Animals↗