[Biochemical changes of ventricular cerebro-spinal fluid in 50 hydrocephalic children (author's transl)].
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Brain↗
Biomedical subjects
C Vivenza
Publications and source records attributed to C Vivenza.
Microsurgical treatment of ten arteriovenous malformations in critical areas of the cerebrum.
Ten cases of arteriovenous malformations located in critical areas of the cerebrum, i.e., motor and speech areas, the insular cortex, the corpus callosum, and the basal ganglia, were treated surgically by radical removal of the lesion. In four of the cases a neurologic examination before surgery was negative; five cases exhibited only mild hemiparesis or dysphasia; only one exhibited hemiplegia and stupor. There were no postoperative deaths and a residual permanent deficit was noted in only one patient. Postoperative control angiograms failed to show any filling of the arteriovenous malformations in any of the cases. Recovery of the ability to work was achieved in all of the patients. The operating microscope and controlled hypotension made possible a precise resection at the edges of the lesion, and damage to surrounding important cerebral structures was thus avoided. Based on these results, microsurgery should be considered as an elective therapy for these kinds of arteriovenous malformations, even when preoperative symptoms are minimal.
Adolescent↗
Acute lymphoblastic leukemia in a girl treated for osteosarcoma.
Acute lymphoblastic leukemia (ALL) was diagnosed in a 13-year-old girl who had been treated previously for osteosarcoma of the left distal femur (23 months after her first cancer onset and 12 months after the end of treatment). The patient started chemotherapy for ALL and achieved complete remission; she is in continuous complete remission 5 years after the diagnosis of secondary ALL and 7 years after the onset of osteosarcoma.
Antineoplastic Combined Chemotherapy Protocols↗
Deep controlled hypotension with sodium nitroprusside in the surgical treatment of intracranial arterial aneurysms.
The authors report 73 cases of intracranial arterial aneurysms operated on under deep controlled hypotension--i.e. hypotension below 60 mmHg of systolic arterial pressure (s.a.p.)--. Deep hypotension was induced by Sodium Nitroprusside (SNP). No problems were encountered in order to reach or to maintain deep hypotension. SNP showed to be an easy hypotensive agent, without toxicity at the recommended dosage. Fifty-nine patients were operated on between 40 and 25 mmHg of s.a.p. In 55 patients deep hypotension lasted for 30 minutes or more, reaching 2 hours in 3 patients. Surgical results were excellent, in regard either to the control of bleeding, either to the dissection of the aneurysm. Clinical results were evaluated by comparison with 146 patients operated on under normal pressure (group of control); no complications were clearly related to deep hypotension per se. However, the authors stress the risks of deep hypotension in early surgery, due to the possible association to vascular spasm.
Blood Pressure↗
[Acute lymphoblastic leukemia in adolescents].
Age is an important prognostic factor in acute childhood lymphoblastic leukemia (ALL): intermediate age children (1-9 years) show a better outcome than infants (0-1 year) and adolescents (10-15 years). However recent literature data do not agree about adolescents worse prognosis. We tried to contribute to this issue with a retrospective analysis about presenting features and survival of 302 pediatric patients (65 adolescents and 237 children) with non B ALL enrolled on AIEOP protocols at the Departments of Pediatric Haematology-Oncology (University of Turin) from 1976 to 1992. The last follow up was 30.11.94. We found in adolescents, in spite of higher frequency of unfavourable prognostic factors (Hb > 8 g/dl, mediastinal mass, T cell immunophenotype, L2 morphology), an event free survival similar to children (EFS 52% vs 51%). In conclusion in our population we found that age at diagnosis greater than 10 years does not represent an unfavorable prognostic factor.
Adolescent↗