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Biomedical subjects

C Vilain

Publications and source records attributed to C Vilain.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Raynaud's phenomenon after chemotherapy. Apropos of 3 cases].

Raynaud's phenomenon is studied in three patients after cancer chemotherapy. In these cases, Raynaud's phenomenon occurs as: a true coincidence, a secondary complication of which neoplastic biological signs are thrombocythemia, hyperfibrinemia, immune complexes, cryoglobulinemia..., a therapeutic implication. The rate of therapeutic implication is difficult to precise. Raynaud's phenomenon is a little symptom over a severe illness. Several drugs are responsible for this fact. A literature review mentions Vincristine, Bleomycin, Cisplatin... For our three patients as in the literature review the tumoral nature is less important than the drug type. For us Bleomycin alone as in association is able to induce Raynaud's phenomenon. The occurrence of single Raynaud's phenomenon may be a systemic scleroderma is first sign. However it is important to affirm the true single Raynaud's phenomenon. In this case there is a lack of signs: scleroderma may be paraneoplastic, drugs may be pulmonary toxic, anticentromere antibodies may be positive during antineoplastic treatment. The pathogenesis for Raynaud phenomenon drug induction is unknown. For Bleomycin action the role of skin concentration, fibroblastic lesion, and vascular disturbance is discussed.

Adenocarcinoma↗
PubMed1985

[National information campaign in France. "One drink is O.K., 3 drinks is asking for trouble"].

Despite a downward trend in the consumption of alcohol during the last 10 years, France remains the main consumer of alcohol in the world. One in every 15 deaths is related to alcohol. Some of the reasons for the decrease in alcohol consumption are: the privilege to distill one's own alcohol is now limited to few people, advertisements are controlled, taxes on liquors have been increased, drunken drivers are severely penalized. Moreover, there have been structural changes, one of them being the installation of an improved piped water system. For the first time, in 1984, the French Committee for Health Education launched an information campaign concerning alcoholism. Traditions and customs related to the consumption of alcohol still have a strong positive connotation in France. So this very important consideration had to be taken into account by the planners of the campaign. The keynote of the campaign was therefore that one should drink moderately. The slogan chosen contains a note of humour which the translation does not render: "One glass is OK, three glasses, and your troubles begin". Television spots were widely used in the campaign as well as pamphlets, and various public relations meetings took place. In a preliminary evaluation, a nation-wide survey showed that 70% of the viewers remembered the slogan three months after the end of the campaign. Out of these, 86% thought the campaign was necessary, and 69% considered the campaign had been well-conceived.

Adolescent↗
PubMed1984

Structural and functional analysis of spontaneous anti-nitrophenyl antibodies in three cyprinid fish species: carp (Cyrinus carpio), goldfish (Carassius auratus) and tench (Tinca tinca).

High spontaneous anti-trinitrophenyl (TNP) activities were found in three Cyprinid fish species: Carp (Cyprinus carpio), Goldfish (Carassius auratus) and Tench (Tinca tinca). The molecules involved, isolated by affinity chromatography on dinitrophenyl-lysine Sepharose (DNP-lysine-Sepharose), had the main characteristics of a high molecular weight immunoglobulin (IgM-like). Affinity measurements were performed on natural anti-DNP/TNP antibodies isolated from nine individual tench sera, using the inhibition of DNP-T4 bacteriophage inactivation technique. The antibodies analysed were more specific for TNP than for DNP. No activity was found against paranitrophenyl hapten. Affinities were all very low, even for TNP. In the three species, natural anti-DNP/TNP antibodies constitute as much as 11 to 16% of the total immunoglobulin concentration. This high level of nitrophenyl-binding serum immunoglobulins either suggests the existence of a particular regulatory mechanism in fish or reflects a generally low antibody diversity in these species.

Animals↗
PubMed1983

Regulation of cell cycle by cytoplasmic components in the amphibian eggs.

Injections of extracts of Xenopus egg cytoplasm induce precocious cleavage furrows in activated Pleurodeles eggs. This cleavage timing system (CTS) activity is retained in two distinct fractions separated by gel filtration. Acceleration of the first cell cycle of the Pleurodeles egg is directly related to the concentration of the injected extracts. However, the maximum advance of the cleavage cycle does not exceed 25 to 30% of the control cycle. Preliminary characterization of these fractions indicates that the CTS effect is abolished after protease but not RNAse treatment, and that the CTS factors are thermostable. The phase of the egg cell cycle sensitive to the CTS factors, which act as a 'clock system mechanism', is discussed.

Animals↗
PubMed1981

Cytoplasmic regulation of the duration of cleavage in amphibian eggs.

Relations between a cytoplasmic species specificity and the duration of cleavage cycles were investigated by reciprocal injections of egg cytoplasm. Xenogenic cytoplasm induces an early or delayed cleavage of the recipient egg depending on the chronological specificity of the injected cell cytoplasm. Activity of the so-called cleavage timing system (CTS) was first detected in the cytoplasm of maturing oocytes at the stage of germinal vesicle breakdown (GVBD). This specific cytoplasmic property was not dependent on the maturation promoting factor (MPF). Relations between the CTS and other cytoplasmic components which are known to induce cleavage are discussed.

Animals↗