Search PubMed⌕ Search

Biomedical subjects

C Viel

Publications and source records attributed to C Viel.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Proposition of chemical topology of principal antiviral molecules by a multiparameter mathematic model: the minimal length graph].

The developed formula of some 200 antiviral molecules were treated by molecular connectivity matrix method. This technic allows the search and the automatically count of structural binary fragments of these molecules. It has been possible to establish a spanning tree (Prim's arborescent squeleton) which gathers the different molecules and permits to put a priori some new structures.

Antiviral Agents↗
PubMed1995

[Did Lavoisier have a laboratory other than that of the Arsenal?].

To this question the author responds in the affirmative. The laboratory was situated near the Palais-Royal. Only Scheler and Smeaton have mentioned it and one might share their thinking that it was located in the home of Lavoisier's friend Augez de Villers.

Chemistry↗
PubMed1995

[The salon and the laboratory of Lavoisier at the Arsenal, the chamber where the new chemistry evolved].

Lavoisier and his wife resided at the Arsenal, near the Bastille, from 1776 to 1792. The author paints a picture of daily life and of the scientific life which they led. He brings into review their collaborators, their students and the visitors who frequented their premises. He recalls the principal points of chemical research which Lavoisier was able to effect there and stresses the high cost of his beautiful laboratory.

Chemistry↗
PubMed1994

Study of structure/activity relationships by multivariate statistical analysis in a series of triazaspirodecanediones with CNS activities.

The CNS activities of thirteen triazaspirodecanediones have been compared by multivariate statistical analysis. The response parameters used in this study were spontaneous motor activity, potentiation of pentobarbital effect, anticonvulsant and anxiolytic activities. Pharmacological data were analyzed using two methods: (1) a factorial correspondence analysis; (2) an automatic analysis based first on a hierarchical clustering represented by a dendrogram and second on the minimum spanning tree method. The obtained results allow to imagine the synthesis of more specific compounds.

Animals↗
PubMed1994

[The first French guide for the use of pharmacy students].

The author analyzes the Nouveau guide de l'étudiant en médecine et en pharmacie published in 1825, in which the section on pharmacy is due to J.-B.-A. Chevallier. In particular he stresses the importance of this work in understanding the history of pharmacy instruction.

Education, Pharmacy↗
PubMed1992

[Structural typology assay of principal anticancer agents on the basis of molecular fragmentation].

The developed formula of 58 anticancer agents used in therapeutic or still in clinical essays were treated by molecular connectivity matrix method. This technic allows the search and the automatically count of structural fragments of the different studied molecules. Then it has been possible to build a spanning tree (Prim's arborescent skeleton) which gathers the different molecules and permits to put a priori new structures.

Antineoplastic Agents↗
PubMed1992

[Utilization of a multiparametric technique for analysis of specificity of different inhibitors of various forms of cyclic nucleotide phosphodiesterases].

Multiple enzymes and compounds were used to study relationship between chemical structure and enzymatic affinity. Reduction of multidimensional data, by mathematical methods, as factorial correspondence analysis (FCA), with simple graphical representation allows to define the relative specificity of various molecules for different enzymatic targets. Using a significative sample of molecule tests and their biological responses it would be possible for each new compound to determine its typology inside its molecular family and to give insight for pharmacological modulation. Papaverine analogues reference drugs and three isolated cyclic nucleotide phosphodiesterase forms were used as experimental model in this analysis.

2',3'-Cyclic-Nucleotide Phosphodiesterases↗
PubMed1992

[Overall analysis of structural factors responsible for the activity and toxicity of antiparasitic agents used in therapy].

A mini-data bank was constituted from the 73 french antiparasitic patent medicines and was implanted in microcomputer. A maximum of chemical, pharmaceutical, therapeutical and toxicological data were collected and treated by multivariate analysis. Exploitation of these informations processing allows to take out correlations between chemical structure toxicity, and specificity.

Anthelmintics↗
PubMed1989

[Multiparameter analysis approach of antiparasitic structure-activity relationships in function of the parasite taxonomy].

In this paper the authors have studied the structure-parasitic activity relationships through the Chemical Abstracts data base which groups together the works published in this field for the last twenty years. With mathematical methods of multidimensional data reduction using a computer it has been possible to validate the classification of human parasites on the base of their sensitivity to chemical families. The specificity of the pharmacochemical relationships was described through two factorial maps. This work shows that it is possible to find new chemical series with potential parasitic activity.

Animals↗
PubMed1988

Molecular properties of the papaverine binding sites identified in human colonic membranes with 6,7-dimethoxy-4-(4'-amino,3'-[125I]iodobenzyl) isoquinoline as probe.

The binding sites for papaverine in human intestine were studied with the radioiodinated papaverine derivative, 6,7-dimethoxy-4-(4'-amino,3'-[125I]iodobenzyl)isoquinoline [( 125I]DMABI) as a probe. This drug was shown to bind to two specific binding sites in human colon membranes; one with a low capacity (Kd = 0.02 +/- 0.01 microM, Bmax = 0.77 +/- 0.15 fmol/mg) and another with a high capacity (Kd = 12 +/- 1.5 microM, Bmax = 167 +/- 20 fmol/mg). The ability of various 4-benzyl isoquinolines derivatives, to inhibit radioligand binding was not influenced by 4'-substitutions, but was influenced by 6,7-substitutions, e.g. 6-hydroxy greater than 7-hydroxy greater than 6,7-dihydroxy; and by other substitutions, e.g. 1-CH3 greater than N-oxyde. The papaverine probe was further used to examine structural aspects of human colon papaverine binding sites. For this purpose, [125I]DMABI-labeled membranes were irradiated with U.V. for 15 min at 4 degrees C. Subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis of membranes revealed a major, specifically labeled protein of Mr = 36,000 Da. This photoaffinity labeling was protected by unlabeled DMABI in a dose-dependent manner (IC50: 0.5 microM).

Affinity Labels↗
PubMed1988

[Not Available].

Explore the source record for details and available documents.

France↗
PubMed1987

Characterization of solubilized isoquinoline binding sites from rat intestine using 6,7-dimethoxy 4-(4'-amino, 3'(125I)iodobenzyl)isoquinoline.

In rat tissues, the specific binding of 6,7-dimethoxy 4-(4'-amino, 3'(125I)iodobenzyl)-isoquinoline is distributed as follows: aorta greater than pancreas greater than liver greater than intestine greater than stomach greater than lung greater than skeletal muscle greater than heart greater than brain. In aorta and intestine 125I-DMABI is specifically covalently incorporated after direct u.v. photolabeling, in a major polypeptide of Mr 36,000 daltons, and a minor polypeptide of Mr 52,000 daltons. In intestine another smaller minor polypeptide of Mr 26,000 is observed. In intestine a variety of isoquinolines are tested for their ability to inhibit the covalent photo-incorporation of 125I-DMABI. Inhibitory potency is influenced by 6,7-substitutions, e.g. 6,7-dimethoxy, and by the presence of benzyl ring in C-1 and C-4 positions. Isoquinoline is much more potent than tetrahydroisoquinoline. 125I-DMABI intestinal binding site is solubilized using Triton X-100. Layered on Sephadex G-25 column, a high specific peak of radioactivity is eluted in the void volume of the column. The 125I-DMABI binding protein loaded onto a Sephacryl S-300 column is eluted as a single peak corresponding to a species with a Stokes radius of 43.5 A. The sedimentation coefficient of the 125I-DMABI binding protein is measured by ultracentrifugation of 5.5 S, using 5-20% sucrose gradient. The calculated molecular weight of the intestinal 125I-DMABI binding protein is estimated at 110,000 daltons.

Animals↗
PubMed1987

Metabolism of 6,7-dimethoxy 4-(4'-chlorobenzyl)isoquinoline. II. Role of liver catechol O-methyltransferase and glutathione.

1. On i.v. administration to rats of 14C-6,7-dimethoxy 4-(4'-chlorobenzyl)isoquinoline (PV2) 23% dose of 14C was excreted in urine and 72% in faeces. The pattern of metabolites showed ten 14C-PV2 derivatives and unchanged PV2. Seven metabolites have been characterized by comparison with authentic compounds e.g. the ketone of PV2, the N-oxide PV2, the demethylated metabolites 6-hydroxy-PV2, 7-hydroxy-PV2 and 6,7-dihydroxy PV2, the benzyl ring-hydroxylated metabolites, 3'-hydroxy-PV2 and 6,7,3'-trihydroxy-PV2. Unchanged PV2 and its metabolites are excreted both free and conjugated. 2. Enzymic O-methylation of 6,7-dihydroxy-PV2 by liver catechol-O-methyl transferase (COMT) in vitro produced 6-hydroxy,7-methoxy-PV2. After blockade of COMT by pyrogallol in vivo, the excretion of 6,7-dihydroxy-PV2 was increased and the excretion of 6-hydroxy, 7-methoxy-PV2 decreased. 3. Hydroxylation of the benzyl ring of PV2 and its metabolites indicates the formation of an intermediate epoxide followed by glutathione conjugation. After glutathione depletion in vivo by diethyl maleate (DEM) liver covalent binding of 14C-PV2 metabolites was increased and biliary excretion of benzyl ring-hydroxylated PV2 metabolites decreased. Replacement of glutathione depletion by a cysteine derivative restored liver covalent binding and the excretion of PV2 metabolites to levels similar to those observed in control rats, indicating that glutathione conjugation may be an important metabolic pathway for the detoxication of PV2 and its metabolites in vivo.

Animals↗