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Biomedical subjects

C Valori

Publications and source records attributed to C Valori.

At least 37 records · Page 2Linked to original sources
PubMed1985

Age and responses to isometric exercise in hypertension: possible predictors of the antihypertensive effect of diuretics and beta-blockers.

In a multicenter, randomized, double-blind study, 108 hypertensive patients were treated with either chlorthalidone 25 mg or slow-release metoprolol 200 mg both given once daily over 4 weeks. Blood pressure and heart rate at rest and at the peak of an isometric exercise test (30% of maximal voluntary contraction for 3 min) were recorded at random and at the end of the study. Both treatments induced a significant (p less than 0.01) blood pressure reduction at rest and at the peak exercise, 50.0% of patients on chlorthalidone and 59.2% on metoprolol, respectively, having a lying diastolic blood pressure less than 95 mmHg. A weak but significant (p less than 0.001) positive correlation was found between age and change in systolic and diastolic blood pressure after chlorthalidone. Such a relationship was absent in the metoprolol group, where a significant (p less than 0.01) positive correlation was found between diastolic pressure rise from rest to the peak exercise at randomization, and the reduction in resting diastolic pressure at the end of the study. Treatments were well tolerated, only a decrease (p less than 0.05) in serum potassium (from 4.4 to 4.0 mEq/l) in the chlorthalidone group was observed. Results suggest that age may influence the antihypertensive response to chlorthalidone, while diastolic pressure rise in isometric exercise may predict the degree of pressure response to sustained beta-adrenergic blockade with metoprolol.

Adrenergic beta-Antagonists↗
PubMed1984

Macrolide antibiotics and serum theophylline levels in relation to the severity of respiratory impairment: a comparison between the effects of erythromycin and josamycin.

Ten patients with exacerbated chronic asthmatic bronchitis, subdivided into two groups on the basis of respiratory failure, were treated with theophylline-ethylendiamine administered by continuous venous infusion (0.7 mg/kg/hr over a period of 132 hrs). The aim of the study was the evaluation of serum theophylline levels during administration of erythromycin or josamycin (500 mg q.i.d. orally for 48) hours). An increase of theophylline levels was registered during erythromycin treatment in the group of patients with greater impairment of the respiratory function, while in the other group no significant change was observed. During josamycin treatment serum theophylline concentrations did not show any increase in both groups and, moreover, a significant reduction (p less than 0.05) was observed in the more seriously ill patients.

Aged↗
PubMed1981

A fixed combination of oxprenolol slow-release and chlorthalidone once daily in treatment of mild to moderate hypertension.

In a multicenter, single-blind, interpatient study, 103 outpatients with mild to moderate hypertension were given, after 2 weeks of placebo wash-out, 160 mg oxprenolol slow-release in fixed combination with chlorthalidone (20 mg per tablet) (SROC 160) once daily or conventional oxprenolol (80 mg) in fixed combination with chlorthalidone (10 mg per tablet) (COC 80) twice daily for 8 weeks. Throughout the study 22 of 51 patients on SROC 160 and 24 of 51 on COC 80 received 1 tablet once daily and, respectively, 1 tablet twice daily. The remaining patients of both groups double the corresponding dosage after the first 4 weeks. Systolic and diastolic blood pressure decreased on both treatments without and difference observed between the groups. Diastolic blood pressure normalization was achieved in both groups in the same number of patients (35). Minor side effects occurred on both treatments: only one patient on SROC 160 interrupted the study due to severe dizziness and fatigue. The advantages are discussed as regards patient's compliance with administration of fixed combination SROC 160 once daily in treatment of mild to moderate hypertension.

Adult↗
PubMed1975

Effect of oxprenolol on catecholamines and plasma renin activity: acute response to frusemide in hypertensive patients.

1. Catecholamine plasma concentrations and urinary excretion were measured together with plasma renin activity in ten patients with essential hypertension and in five normal control subjects before and after a frusemide challenge. 2. The same procedure was repeated in the same subjects 3--4 days later after pretreatment with oxprenolol. 3. Noradrenaline plasma concentrations and urinary excretion increased significantly after frusemide in all cases, returning to normal values at 30 and 60 min. Adrenaline plasma concentrations and urinary excretion were unchanged. 4. Plasma renin activity increased significantly in seven patients with hypertension and normal renin basal values, remaining unchanged in three hypertensive patients with low-renin basal values. 5. Oxprenolol suppressed the response of noradrenaline and plasma renin activity to frusemide in all cases.

Adult↗
PubMed1975

[Exercise test and atrial pacing in angina pectoris: behaviour of adrenosympathetic system (author's transl)].

Arterial plasma noradrenaline and adrenaline concentrations before, during and after an attack of pain, induced first by constant supine exercise and then by multistep atrial pacing, were determined in four patients with coronary occlusion disease and stable angina pectoris. An identical protocol was applied to a patient with atypical precordial pain (anxiety state) and normal coronary arteriograms. When compared, the results led to the following conclusions: 1) during supine exercise arterial plasma catecholamine concentrations, particularly noradrenaline, progressively increase, reaching highest values in temporal coincidence with the onset or the peak of pain, 2) during multistep atrial pacing-induced angina no significant changes of arterial plasma catecholamine concentrations are seen. These data, obtained from the same patients, further emphasize that the application of atrial pacing to the study of pathophysiology of angina pectoris and for evaluating antianginal drugs, especially if interfering with adrenosympathetic system activity, must be considered with caution.

Adrenal Glands↗
PubMed1970

[Diuretics].

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Benzothiadiazines↗