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Biomedical subjects

C V Williams

Publications and source records attributed to C V Williams.

22 records · Page 2Linked to original sources
PubMed1980

Frequency of chromosomal abnormalities in early embryos of the domestic sheep (Ovis aries).

Embryos or unfertilized eggs were collected 2 or 3 days post coitum from mature sheep of various breeds and crosses. The karyotypes of 89 of the 376 collected were established. There were 44 embryos with 2n = 54XX, 30 with 2n = 54XY;1 was a 2n/1n mouse; 4 had 2n + 1 chromosomes giving an incidence of trisomy of 4.7%; and 1 unfertilized egg had n = 28. The incidence of chromosomal abnormalities was 6%, and 1.3% of the eggs or embryos had a cracked zona pellucida.

Animals↗
PubMed1978

Ovarian and hypothalamic response to sequential increases in the amount of clomiphene administered to the same group of oligomenorrhoeic women.

Ten patients with oligomenorrhoea were investigated using increasing doses of clomiphene citrate in each cycle. The starting dose was 50 mg on day 1 of the cycle for 5 days and was increased by 50 mg per day for 5 days per cycle, to a maximum dose of 200 mg per day. Urinary total oestrogen concentration was measured on Day 1 to 3, 12 to 14 and on Day 21. Peripheral venous plasma concentrations of immunoreactive LH & FSH on Days 1 to 3 and 12 to 14 and the peripheral venous plasma concentration of immunoreactive progesterone on Day 21 were measured. The response to treatment is discussed in relation to hormone levels in the early follicular phase and to the dose of clomiphene administered. No correlation was found between hormone levels in the early follicular phase and increments in oestrogen and LH concentrations at midcycle. On a low dose regime the increment in FSH at midcycle was significantly greater in patients with a normal FSH concentration in the early follicular phase than in those with a low FSH level at this phase in the cycle. The results of treatment with clomiphene were not changed by an increase in dose from 50 mg to 150 mg but an increase to 200 mg significantly reduced the magnitude of response.

Adult↗
PubMed1975

Changes in pituitary and ovarian hormones following injection of ultra low dose LH-RH in normal and amenorrhoeic women.

The results of the ultra low doses of synthetic LH-RH, 1.56, 3.125 and 6.25 mug, are presented in 8 normal women during the first week of the menstrual cycle and 14 patients with secondary amenorrhoea. Seven of these patients had "stress" amenorrhoea, and 7 had preceeding oligomenorrhoea. There was no significant difference between the mean basal gonadotrophin levels in the normal volunteers and those patients with secondary amenorrhoea. There was no significant difference in basal gonadotrophin levels or the response to LH-RH, between the two groups of amenorrhoea, stress and previous oligomenorrhoea. Basal FSH and oestradiol levels do not appear to influence the response to LH-RH. However, those patients with secondary amenorrhoea and a low basal LH (5 patients) had a significantly higher response to LH-RH at 1.56 and 3.125 mug than the amenorrhoeic patients with normal basal LH levels. Two patients with stress amenorrhoea and weight loss had an exaggerated response to LH-RH. The significance of this is discussed.

Amenorrhea↗