Search PubMed⌕ Search

Biomedical subjects

C V Reddy

Publications and source records attributed to C V Reddy.

At least 73 records · Page 4Linked to original sources
PubMed1980

Effect of nitroglycerin ointment on hemodynamics in patients with mitral insufficiency.

A reduction in impedance or afterload produces beneficial hemodynamic effects in patients with mitral regurgitation. This mechanism has been studied via intravenous infusion of nitroprusside, phentolamine, and hydralazine. But there is little information on the effect of nitroglycerin ointment in patients with mitral insufficiency. Thus 6 patients with mitral insufficiency underwent right and left heart catheterization. After the control hemodynamic measurements were recorded, a 2 1/2-inch strip of 2% nitroglycerin ointment was applied to the chest for half an hour. Pressure recordings and cardiac output were then repeated. The control cardiac index fell from 2.79 to a treatment value of 2.05 L/min/m2 (P < 0.01), while the stroke index also decreased from 29 to 22 ml/beat/m2 (P < 0.05). There was a nonsignificant increase in peripheral resistance. Thus nitroglycerin ointment can be detrimental when given to patients with mitral insufficiency.

Adult↗
PubMed1980

Cardiac effects of alcohol.

There is little information on the echocardiographic evaluation of left ventricular performance after the ingestion of alcohol. Therefore, we obtained echocardiograms and systolic time intervals in 9 normal subjects before and after a cocktail party. These subjects drank 5-6 ounces of 87 proof whiskey during the party. An additional 19 normal subjects drank 3 ounces of 87 proof whiskey and had similar studies performed. The results of the study with 5-6 ounces of alcohol are in Table 3. The 19 subjects who drank 3 ounces of alcohol showed no statistical changes except that the systolic ejection time fell from a control of 0.31 +/- 03 (see formula in text) to 0.30 +/- 0.4 (P less than 0.05). These data indicate that 5-6 ounces of whiskey can depress left ventricular function in normal subjects.

Adult↗
PubMed1979

Electrophysiologic properties of coffee in man.

There is no information on the effects of coffee on the human conduction system. His bundle electrograms were obtained in 12 patients before and 20 minutes after the ingestion of coffee containing 150 mg caffeine. Antegrade and retrograde refractory periods were obtained with the extrastimulus method. The effective and functional refractory period of the atrioventricular node decreased after coffee ingestion. This improvement in conduction is probably mediated by a release of catecholamines.

Adult↗
PubMed1979

Inappropriate slowing of the pacemaker rate with programmable demand pacemaker.

A 60-year-old male with a programmable pacemaker developed inappropriate slowing of the pacemaker rate. This was due to oversensing of the T waves combined with after-potential sensing. This does not represent generator malfunction and can usually be corrected by reprogramming the pulse duration, or the milliamperage.

Electrocardiography↗
PubMed1979

His bundle electrogram in patients with acute myocardial infarction.

Thirty-seven patients with acute myocardial infarction complicated by atrioventricular or bundle branch block, or a combination of both, has His bundle electrogram studies performed during their stay in the coronary care unit. The acute mortality of the 14 patients with a complicating bundle branch was 50%. Pump failure was the main cause of death. Three patients in this group had a prolonged H-V interval and one patient had a split blundle of His. The presence or absence of a prolonged H-V interval did not affect mortality in this group of patients. The acute mortality of the 16 patients with an inferior wall myocardial infarction was 6%. The H-V interval was normal in all but one of these patients. The atrioventricular block was caused by a proximal block in all cases. The acute mortality of the seven patients with an anterior wall myocardial infarction was 29%. The H-V interval was prolonged in two of seven patients. Pump failure was the acute cause of the deaths. The presence or absence of a prolonged H-V interval did not affect mortality in this group of patients.

Adult↗
PubMed1979

Decline of serum phosphorus in acute myocardial infarction.

Levels of serum calcium, phosphorus, magnesium, SGOT, CPK, and LDH were measured in 61 patients admitted to a coronary care unit. In 34 the ECG and enzymes confirmed an acute myocardial infarction, whereas the remaining 27 did not have an acute myocardial infarction. The serum phosphorus declined significantly in those with the acute infarction compared to the control group. The fall was most marked in the third and fourth postinfarction day, and by the fifth day had returned to baseline values. The serum calcium and magnesium did not change significantly over the 5 days. Thus the fall in the serum phosphorus serves as a sensitive indicator of acute myocardial infarction.

Acute Disease↗
PubMed1979

Hemodynamic effects of phentolamine in mitral stenosis and congestive cardiomyopahty.

Nine patients with alcoholic cardiomyopathy and 8 patients with mitral stenosis were studied by right and left heart catheterization. Hemodynamic observations were made during control period and during the infusion of phentolamine at a rate of 0.3 mg per minute. The patients with the cardiomyopathy responded to phentolamine with a significant decline in the left ventricular filling pressure, pulmonary artery mean pressure, peripheral resistance, and arteriovenous oxygen difference. There was a significant increase in the cardiac index. The patients with mitral stenosis did not show any hemodynamic improvement after phentolamine infusion.

Cardiac Output↗
PubMed1979

Oral therapy with phentolamine in chronic congestive heart failure.

Therapy with phentolamine can improve the condition of patients with congestive heart failure due to the inotropic effect of this drug, as well as its vasodilating action. The use of oral therapy with phentolamine has not been adequately investigated in patients with chronic heart failure. Therefore, nine patients with chronic heart failure due to underlying valvular disease received 50 mg of phentolamine four times a day for two weeks. Echocardiograms and measurements of systolic time intervals were obtained prior to administration of phentolamine and two weeks after the introduction of therapy with the drug. As a result of therapy with phentolamine, the ejection fraction, the percentage of change in the minor axis, and the velocity of circumferential fiber shortening significantly increased, while the left atrial dimension decreased. Therapy with phentolamine produced a significant decrease in the preejection period index, as well as the ratio of the preejection period over the left ventricular ejection time. Thus, oral therapy with phentolamine improves left ventricular function in patients with chronic heart failure.

Administration, Oral↗
PubMed1979

Pericardial effusion as an early complication of acute myocardial infarction.

Two days after an acute myocardial infarction, a patient developed pleuropericarditis. A negative lung scan and echocardiographic evidence of pericardial effusion were instrumental in making the diagnosis. Steroid therapy led to a dramatic resolution of the signs and symptoms. Pericardial effusion is usually a late complication of myocardial infarction (Dressler's syndrome), but the increasing use of echocardiography may demonstrate that it occurs early in the course.

Acute Disease↗
PubMed1978

Hemodynamic effects of morphine in cardiac disease.

The hemodynamic effects of intravenous morphine were documented by right heart catheterization in six patients with an acute uncomplicated transmural myocardial infarction one to three days after the onset of symptoms. Intracardiac pressures, brachial artery pressure, and cardiac output were determined before and 15 minutes after the termination of the morphine infusion. Five milligrams morphine was given intravenously over a 10-minute period. The brachial artery pressure fell from a mean of 78 to a mean of 73 mm Hg (NS). As a result or morphine administration, the average cardiac index decreased from 2.68 to 2.31 liters/min-m2 (P is less than 0.05), and the stroke index decreased from 27 to 22 ml/beat-m2 (P is less than 0.05). Only small changes were observed in the intracardiac pressures.

Adult↗
PubMed1978

The sick sinus syndrome. A study of 50 cases.

The long term prognosis was studied in 50 patients treated for the sick sinus syndrome with pacemaker insertion. The mean age of the patients was 71 years. There were 31 females and 19 males in the series. Nine patients (18%) died during the average follow-up period of 19 months. Dizzy and syncopal episodes were abolished in most patients with pacemaker therapy. However only two of the nine patients in congestive heart failure improved with the pacemaker. Thus the long term prognosis of patients with the sick sinus syndrome is poor despite pacemaker therapy. This is particularly true for the patient in chronic congestive heart failure who does not respond to the pacemaker treatment.

Adult↗