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Biomedical subjects

C Urmacher

Publications and source records attributed to C Urmacher.

66 records · Page 4Linked to original sources
PubMed1982

Radiographic changes in primary osteogenic sarcoma following intensive chemotherapy. Radiological-pathological correlation in 63 patients.

Sixty-three patients with osteogenic sarcoma of the long bones, all of whom were treated with chemotherapy, demonstrated striking and unusual radiographic changes. Patients with a "good" radiographic response (48%) showed the most dramatic changes, including medullary sclerosis, prominent periosteal new bone formation, and disappearance of the soft-tissue mass; and these findings correlated well with the histological grading of the surgical specimens. Radiographic evaluation of patients receiving chemotherapy for osteogenic sarcoma is a valuable method of assessing response.

Adolescent↗
PubMed1981

The use of cross-leg flap in malignancy: realization of a potential complication.

We present a case of recurrent myxoid fibrosarcoma presumed to have spread to the contralateral leg by means of cross-leg flap procedure. In the era of free flap transfer, musculocutaneous flaps and the recent cross-leg musculocutaneous flap, the cross-leg flap remains a valuable technique for the reconstructive plastic surgeon. However, it should not be considered in reconstruction after resection of a malignant tumor.

Biopsy↗
PubMedDate not supplied

Cytologic findings in homosexual males with acquired immunodeficiency.

During a three-year period (1979 to 1982), 248 cytology specimens were obtained from 38 homosexual males who were admitted for treatment and had a variety of nonspecific symptoms, such as general malaise and weight loss. Twenty patients had Kaposi's sarcoma. Exfoliative and aspiration/brush specimens were prepared mainly from cerebrospinal fluids and tracheobronchial secretions. One hundred twenty-four specimens were of diagnostic value, exhibiting cytologic abnormalities: acute inflammation (11 specimens), marked cellular atypia (39 specimens), increased number of mature and immature lymphoreticular elements (31 specimens) and organisms such as parasites and fungi (43 specimens). Awareness of an epidemic of acquired immuno-deficiency-associated disease among male homosexuals, in conjunction with special processing and careful interpretation of cytologic specimens, contributed to the identification of organisms and the ruling out of malignancy. Despite prompt treatment, a swiftly progressive clinical course resulted in the death of 20 patients.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Cytology of cervical chordoma in cerebrospinal fluid from a child. A case report.

The cytologic findings on cerebrospinal fluid examination of cervical chordoma in a 2-year-old girl are presented. The major cell type was a small, isolated, hyperchromatic cell with sharply defined nuclear membrane and granular cytoplasm. However, the characteristic cell of this neoplasm, the so-called physaliferous cell with typical bubbly cytoplasm, was also noted. Cytologic findings were compared to biopsy findings, with a good correlation of tumor morphology. Clinical follow-up revealed unusually aggressive tumor behavior, and the patient died a year later despite intensive chemotherapy. The differential diagnosis of the condition is also discussed.

Brain Neoplasms↗
PubMedDate not supplied

Recurrent deletions involving chromosomes 1, 5, 17, and 18 in colorectal carcinoma: possible role in biological and clinical behavior of tumors.

We have employed cytogenetic and restriction fragment length polymorphism (RFLP) analysis to identify a full spectrum of cytogenetic and molecular alterations associated with initiation and progression of "sporadic" colorectal cancer and also to correlate the alterations with biological and clinical behavior of the tumors. The study series included 63 colorectal cancers, 47 primary and 16 metastatic recurrences. Cytogenetic analysis was successful in 48 tumors (76%) of which 44 (91%) were abnormal. Of these 44 tumors, clonal abnormalities were identified in 43, whereas chromosomes from one tumor were unsuitable for complete analysis. Each of these abnormal tumors displayed heterogeneity with regard to extent and complexity of recurrent chromosomal abnormalities. Numerical losses of chromosomes 17 and 18 (20-34%) and gains of chromosome 7 (28%) were significantly higher. The four most frequent structural rearrangements on the other hand, involved specific regions of chromosomes 1p, 5q, 17p, and 18q. The shortest regions of overlap of these rearrangements or losses were located at 1p36, 5q21-22, 17p13 and 18q21- > ter. RFLP analysis directed at 1p, 5q, 17p and 18q identified allelic deletions of these regions in 39 tumors (64%) which included 17 normal and 11 cytogenetic failures. Of all the informative tumors, 32%, 37%, 31%, and 63% showed allelic losses at chromosomes 1p, 5q, 17p and 18q respectively. The two methods of analysis (cytogenetics and RFLP) employed to identify genetic alterations were complementary; probes for chromosome 1 and 18 showed the greatest degree of concordance, whereas probes for chromosomes 5 and 17 provided relatively higher rate of discordance with cytogenetic results. These differences could be attributed mainly to three reasons: 1) a limited number of probes used for RFLP analysis; 2) contamination of tumor cells with normal cells, and 3) either mutational inactivation or deletion of specific alleles not closely linked to the probes used. Regardless of these limitations, however, the combined use of cytogenetic and RFLP identified genetic alterations in a large number of tumors and help elucidate the role of hyperdiploidy and/or relative deficiency of a given chromosomal segment in expression of recessive mutations. In addition, alterations of either chromosomes 1 or 17 predicted poorer survival for the patients with primary colorectal cancer (p = 0.03).

Blotting, Southern↗
PubMedDate not supplied

Intestinal microsporidiosis. Report of five cases.

Five cases of intestinal microsporidiosis are reported, including one case of a heterosexual female acquired immunodeficiency syndrome (AIDS) patient, three homosexual males, and one bisexual male AIDS patients with detailed description of their clinical course. These five cases underscore the severity of immunodeficiency in patients with microsporidiosis. All patients had multiple opportunistic infections and a CD4 cell count below 100/microliters long before diarrhea developed. This is the first kinetic study of helper T-lymphocytes in cases of microsporidiosis. Diagnosis was made by duodenal biopsies stained with Brown and Brenn or Gram-Weigert technique (confirmed by electron microscopy) and by stool smears stained with a modified trichrome technique. However, the best preparation was plastic sections stained with toluidine blue, which demonstrated both the spores and plasmodia clearly. In our evaluation, Giemsa stain was also acceptable for identification of microsporidian spores in both intestinal biopsies and stool smears, but there was a failure to identify the organism on hematoxylin and eosin, acid-fast, periodic acid-Schiff, and Gomeri's methenamine silver stained preparations. Therapeutic attempts using albendazole, metronidazole, octreotide, and zidovudine (AZT) failed to eradicate microsporidia in these patients.

Acquired Immunodeficiency Syndrome↗