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C Turc-Carel

Publications and source records attributed to C Turc-Carel.

94 records · Page 6Linked to original sources
PubMed1982

[Constitutional chromosome abnormalities and acute leukemia].

A review on the association between acute leukemias (AL) and constitutional chromosome abnormalities (CCA) is presented. AL, myeloblastic or lymphoblastic according to age are 16 to 20 times more frequent in Down Syndrome (DS) children than in non DS children. The incidence of acquired chromosome abnormalities is similar in leukemic cells of DS and non DS patients but the type of anomalies, in the leukemic myeloblastic cells of DS, are different: hyperdiploidy, excess of C, F and G. Gain of chromosomes 8, 19 and 22 would characterize leukemic myeloblasts in an early stage of differentiation. Recent data on transient leukemoid reactions show that a 21 in DS appears to be predisposing factor in the development of AL. Association between AL and other balanced or unbalanced CCA appears until now to be fortuitous.

Acute Disease↗
PubMed1982

[Introduction to the cytogenetic study of acute leukemias].

Chromosome banding techniques have been useful to define abnormal chromosomes in acute leukemia. The comparison between cases reported from different centers has been possible only with the acceptance of a universal system of classification and nomenclature for acute leukemia as well as for chromosomal rearrangements. Chromosomes abnormalities in acute leukemia are found in about 50 per cent of patients. They appear to be non random. Clinical, morphologic and cytogenetic findings have been correlated. Diagnosis and prognosis significance of chromosome abnormalities is of importance. The problem of normal or so called normal cells in 50 per cent of acute leukemia is set.

Acute Disease↗
PubMedDate not supplied

The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11).

The mouse cellular oncogene int-1 is often transcriptionally activated as a consequence of nearby proviral insertions in mouse mammary tumors. A highly conserved sequence has been found in the human genome, called int-1 gene, the role of which in human tumors is not known. By somatic hybrids, the human int-1 gene has been assigned to the segment 12q14-12pter. Using a genomic DNA clone containing the fourth exon of the human int-1 gene we have mapped the human int-1 gene to 12q12-12q13. To determine whether this gene, which is located close to the 12q13 breakpoint associated with myxoid liposarcoma, is rearranged in these tumors, we have performed Southern blot analysis of DNA from myxoid liposarcomas carrying the translocation t(12;16) (q13;p11). In the two tumors investigated, the translocation does not disrupt the int-1 gene.

Chromosome Mapping↗