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Biomedical subjects

C Toussaint

Publications and source records attributed to C Toussaint.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Mesenchymal breast sarcomas. Apropos of 25 cases].

Breast sarcoma are rare, representing 1% of all malignant breast tumours. This is a retrospective study of 25 patients with a breast sarcoma, treated at Institut Gustave Roussy from 1954 to 1981. Thirty six per cent of these arose in a cystosarcoma phyllodes. A variety of histologies were found, the main one being malignant fibrohistiocytoma (44%). Nodal involvement was rare (4%) and, as in other sarcoma, hematogenous spread of metastases was more usual. Local recurrence occurred in 44% of cases and distant metastases (usually pulmonary) in 24%. The 3 year disease-free survival was 60% and the major prognostic factor was the mitotic index. Surgery is the treatment of choice of these tumours, supplemented by local irradiation in those cases where only a tumorectomy has been performed. The role of adjuvant chemotherapy remains undefined.

Adolescent↗
PubMed1985

Cyclosporine nephropathy after heart and heart-lung transplantation.

Cyclosporine nephrotoxicity after heart transplantation can lead to acute renal failure requiring haemodialysis. In four long-term heart-transplant survivors, cyclosporine nephropathy was characterised by extensive fibrosis, with uraemia, hypertension and/or anaemia. In contrast, the long-term survivor of heart-lung transplantation who had received her graft for accelerated respiratory failure, did not develop chronic renal disease. Thus, chronically reduced renal perfusion before heart transplantation may play a critical role in the development of chronic cyclosporine nephropathy.

Adult↗
PubMed1983

[Aseptic osteonecrosis after renal transplantation].

In a series of 388 kidney transplantations performed in 328 patients, aseptic bone necrosis was diagnosed in 27 patients. Forty seven lesions were detected. The femoral head was most often involved (33 cases) followed by the femoral condyle (10 cases), the head of the humerus (3 cases) and the carpal navicular bone (1 case). Sixteen patients had multiple lesions. The first symptoms occurred between the fifth month and the sixth year post-transplantation. With our immunosuppressive protocol, the probability of developing aseptic bone necrosis is 5.2% at one year, 11.3% at two years and 16.3% at six years. The incidence of steroid diabetes is higher in patients with aseptic bone necrosis (26%) than in patients without bone lesions (11%). Conservative treatment was successful in 60% of the cases.

Adrenal Cortex Hormones↗
PubMed1983

Prevalence and causes of hypertension late after renal transplantation.

We analysed the prevalence and causes of hypertension in 77 patients followed greater than or equal to 7 years after renal transplantation. Prevalence of hypertension remains stable, around 55 per cent, up to 11 years post-transplant. Age, sex, type of original nephropathy, graft source or prednisolone dosage are not related to hypertension; body weight is greater in hypertensive patients. Presence of native kidneys is responsible for hypertension in about one-quarter of non-nephrectomised patients. No renal artery stenosis was observed in this group. At seven years, serum creatinine is greater in hypertensive patients, suggesting that graft dysfunction is an important cause of hypertension in long term survivors.

Adolescent↗
PubMed1983

[Factors influencing the survival of the patient and the graft in kidney transplants].

The influence of several prognostic factors in kidney transplantation was studied by the actuarial method from the data collected on 332 grafts performed at one center from 1971 to 1982. Taking into account the various interactions between these factors, 3 survival parameters were calculated: patient's survival, immunologic tolerance of the graft and overall graft survival. The relevant prognostic factors, ranked in decreasing order, are: origin of the graft, immunosuppressive therapy, recipient's age, recipient's HBs status and number of blood transfusions administered prior to transplantation, HLA presensitization and HLA-A,B matching. Integration of these factors leads to a precise estimation of the risk of transplantation from the characteristics of the graft and those of the potential recipients, thereby allowing to select the best candidate.

Adult↗
PubMed1983

Flupenthixol versus haloperidol in acute psychosis.

Forty acutely psychotic patients were treated either with flupenthixol drops or haloperidol drops in an open, 28-day controlled study. The flupenthixol group comprised 11 schizophrenic, 8 manic, and 1 paranoid patient and there were 10 schizophrenic, 5 manic, and 5 paranoid patients in the haloperidol group. Mean daily dosage was approximately 112 mg flupenthixol and 18 mg haloperidol. Clinically, both drugs showed an antipsychotic effect. In the schizophrenic patients there was a definite trend towards a more rapid relief of the psychotic symptoms after flupenthixol treatment. In contrast to haloperidol, flupenthixol showed a mood elevating effect and an effect on the negative symptoms, e.g. emotional withdrawal, motor retardation, blunted affect, and disorientation. With both drugs, the most troublesome side-effects were extrapyramidal in nature. Initially, they were more common in the flupenthixol group: later the incidence was similar.

Acute Disease↗