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Biomedical subjects

C Tomassini

Publications and source records attributed to C Tomassini.

6 recordsLinked to original sources

Proximity of older women to their children: a comparison of Britain and Italy.

This research examined differences between Britain and Italy in the proximity of older women (aged 60-74) to their children. We hypothesized that in Britain proximity is more likely to result from the needs of the older generation, whereas in Italy it is more likely to reflect a cultural preference. Employing data from the British Retirement Survey follow-up in 1994, and the 1995 Italian Indagine Multiscopo sulle Famiglie, we applied multinomial logit models to examine the correlates of proximity. Our findings showed that, in Britain, mothers' health had a greater impact on proximity than in Italy, suggesting that the needs of the older generation in Britain were important for determining proximity. An additional analysis showed that children's characteristics were also important in determining proximity in Italy, mainly because of delayed adult transitions. This supports the hypothesis that intergenerational proximity in Italy is more likely to be a response to the needs of children than of parents.

Activities of Daily Living↗

Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy.

OBJECTIVE: To evaluate whether serum levels of the soluble form of CD30 (sCD30) correlate with disease activity in early rheumatoid arthritis (RA) and may have prognostic value in predicting the response to disease-modifying anti-rheumatic drugs (DMARDs). METHODS: The levels of sCD30 and C-reactive protein (CRP) were measured in the serum of 14 untreated subjects with early RA, before and during treatment with hydroxychloroquine, for a follow-up period of 8 months. At the end of the study, patients were also evaluated for their response to DMARDs. RESULTS: An inverse correlation between sCD30 and CRP serum values was demonstrated at baseline, but not during the follow-up. Patients who responded to DMARD therapy had higher sCD30 basal levels than non-responders. CONCLUSIONS: The evaluation of sCD30 serum levels in early RA may reflect the attempt by CD30+ T cells to downmodulate inflammation and may be a useful marker to predict a good response to DMARDs.

Adult↗

High levels of the soluble form of CD30 molecule in rheumatoid arthritis (RA) are expression of CD30+ T cell involvement in the inflamed joints.

The CD30 is a surface molecule expressed by Th2-type lymphokine-producing T cells upon activation. CD30-expressing activated T cells release a soluble form of the molecule, which can be detectable both in vitro and in vivo. In the present study, high levels of soluble CD30 were found in peripheral blood and synovial fluid from patients with RA. However, CD30+ CD3+ cells, either CD4+ or CD8+, were significantly present in synovial fluid, but not in peripheral blood, of RA patients. Serum values of soluble CD30 were higher in active than inactive RA patients and directly correlated with rheumatoid factor serum titres. These data strongly support an involvement of CD30+ T cells in the immune processes of rheumatoid synovitis, and may suggest a relationship between Th2-type cytokine-secreting T cells and the pathological response in RA.

Adult↗

[Spigelian hernias].

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Abdominal Muscles↗