Biomedical subjects

C Tidd

Publications and source records attributed to C Tidd.

3 recordsLinked to original sources

PubMed1999

Compliance, control, & computers.

This systematic method for developing computer-based controls to mitigate identified risk areas and to strengthen internal controls can help agencies implement an effective compliance program. These guidelines should help agencies analyze the extent to which their information systems support the controls that are needed. If an agency believes that it needs more or stronger computer-based controls, these guidelines can serve as a starting point for developing and implementing those controls.

Algorithms↗

PubMed1992

Cervicovaginal cytology in carcinosarcoma [malignant mixed mullerian (mesodermal) tumor] of the uterus.

We examined the cervicovaginal cytology (PAP) findings in a series of 21 endometrial and 2 cervical carcinosarcomas (CS) [malignant mixed mullerian (mesodermal) tumors] (MMMT). Initial cytology diagnosis was positive for cancer in 14 of 23 cases (sensitivity of 61%); however, CS was correctly identified only 2 times. The remaining 12 cancer diagnoses were carcinomas: 10 adenocarcinomas (4 endometrial, 1 cervical, and 5 adenocarcinomas not otherwise specified), 1 squamous carcinoma, and 1 poorly differentiated carcinoma. Seventeen smears were available for review, all 8 false negative, one unsatisfactory, and 8 of 14 true positive smears. One false negative smear showed rare clusters diagnostic of adenocarcinoma. The remaining 7 false negative smears showed 3 high grade squamous dysplasias (two with additional findings: one showed atypical spindle cells and the other showed endometrial stromal cells), 2 extensive repair changes, and 2 negatives. The unsatisfactory smear showed atypical spindle cells. Review of the 8 true positive smears confirmed malignant spindle cells in the two cases originally identified as CS by cytology and in 3 other cases originally identified as adenocarcinoma. Of 9 smears positive for cancer available for review, 4 showed only carcinoma cells. PAP positive for cancer was associated with high stage at presentation (P less than .025) and recurrent disease (P less than .001) (even among stage I or II patients, P less than .025). PAP positive for cancer showed no association with depth of myometrial invasion, size, grade, or histologic type of carcinosarcoma. The results of this study demonstrate the importance of consultative cytology reporting in which recommendations for appropriate biopsy are included in the report.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

PubMed1991

Stability of dendritic mass during aestivation.

In hot and dry weather, terrestrial snails withdraw into their shells and remain inactive for long periods of time. This phenomenon, known as aestivation, is the basis for our investigation of the effects of behavioral inactivity on neuronal structure. Several recent studies have shown that the level of afferent electrical activity is an important modifier of structure, even in adult animals. During aestivation, sensory stimulation (and therefore presumably afferent activity) is greatly reduced. We have tested the hypothesis that long-term behavioral inactivity causes a regression of dendrites. Two identified neurons of Achatina fulica were selected for study, the giant cerebral neuron (GCN) and RPall. The cells were viewed on 10-micron-thick sections after intracellular injection of hexamminecobalt chloride. They were reconstructed by using a video camera attached to a light microscope and a digitizing board resident in a microcomputer. Snails in the aestivated group were completely inactive for 8 weeks beginning at age 23 weeks. A quantitative analysis showed that there were no significant differences in either cell, in either the total mass of material or its distribution, comparing cells from the Aestivated snails and cells from the Younger snails (age 23 weeks) and the Older snails (age 33 weeks). These results suggest limits to the modifiability of neuronal structure.

Animals↗