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Biomedical subjects

C Tang

Publications and source records attributed to C Tang.

At least 253 records · Page 14Linked to original sources
PubMed1989

Primate brain tolerance to temporary focal cerebral ischemia during isoflurane- or sodium nitroprusside-induced hypotension.

Isoflurane has properties that suggest it may provide cerebral protection from ischemia. This study compared, in primates, neurologic outcome after a 45-min period of temporary focal ischemia during hypotension induced with either isoflurane or sodium nitroprusside (SNP). Fourteen macaque monkeys were studied. Seven animals received halothane and seven isoflurane anesthesia during surgical preparation. After transorbital exposure of the middle cerebral artery (MCA), in the halothane group, the inspired halothane was reduced to 0.75% and the mean blood pressure (BP) reduced to 50 mmHg by the infusion of SNP. In the isoflurane group, the isoflurane was titrated to reduce mean BP to 50 mmHg. Stable hypotension was maintained for 90 min, which included a 45-min period of MCA occlusion. Monitoring included intraarterial blood pressure, arterial blood gases, EEG, somatosensory evoked potentials (SEP), and temperature. After the procedure the animals were allowed to awaken and were assessed neurologically every 8 h. On the third postoperative day, they were reanesthetized and underwent magnetic resonance imaging (MRI) and SEP recording. Thereafter, they were killed with iv KCl and the brains fixed for neuropathology. All animals survived the surgical procedure, but two animals receiving halothane and none receiving isoflurane died prematurely (P less than 0.2). The SEP disappeared in all animals within 10 min of MCA occlusion and then returned partially or completely. There was no difference between groups in neurologic scores, in the size of the lesion as assessed by MRI (isoflurane 15.7 +/- 6%, halothane/SNP 10.5 +/- 4%), or in the extent or severity of the neuropathologic lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1989

Pharmacokinetics of vasopressin and atrial natriuretic peptide in anesthetized rabbits.

The elimination from plasma of the peptide hormones vasopressin (VP) and atrial natriuretic peptide (ANP) as well as the time course of release and elimination of these hormones after a physiological stimulus were studied in anesthetized rabbits. As an inverse relationship was found to exist between carotid sinus pressure and plasma IR-ANP, a decrease in carotid sinus pressure to 60 mm Hg was used to stimulate ANP as well as VP release. The elimination of VP after iv injection involved a rapid initial phase and a slow late component, with corresponding half-life (t1/2) values of 0.9 and 5.4 min, respectively. After reduction of carotid sinus pressure to 60 mm Hg, plasma VP increased significantly within 1 min and reached a maximum at 10 min. When carotid sinus pressure was increased to 160 mm Hg to inhibit VP release, the t1/2 of VP was 1.3 min. The t1/2 of immunoreactive (IR) ANP after iv infusion was 1.2 min. Plasma IR-ANP was significantly increased 2 min after carotid sinus pressure was decreased, and a maximum was observed at 10 min. The t1/2 of IR-ANP after elevation of carotid sinus pressure to 160 mm Hg was 3.2 min. These studies indicate that both VP and IR-ANP are rapidly eliminated in the anesthetized rabbit.

Anesthesia↗
PubMed1984

Resistance of schedule-induced behaviours to hippocampal lesions.

It has been reported that electrolytic lesions of the hippocampus accelerate the onset of schedule-induced drinking (SID) and also lead to significant increases in adrenal weights [2]. In the present experiment three groups of Long Evans rats received electrolytic or 6-Hydroxydopamine or sham lesions of the hippocampus and one group received electrolytic cortical lesions. Half of each group were tested 1 hr/day for 10 days under scheduled food delivery and the other half received food in a single presentation. It was found that both electrolytic hippocampal and cortical lesions reduced the level of SID compared with sham and 6-Hydroxydopamine lesions which did not differ from each other. However, there is support for the suggestion that hippocampal catecholamine neurones are involved in corticosterone regulation as shown by a significant increase in plasma corticosterone levels in non-scheduled, 6-Hydroxydopamine lesioned rats.

Animals↗
PubMed1984

Escape from strange repellers.

In a dynamical system described by a map, it may be that a "strange" sets of points is left invariant under the mapping. The set is a repeller if points placed in its neighborhood move away. An escape rate is defined to describe this motion. An alternative method of evaluating the escape rate, based on the consideration of repulsive cycles, is proposed. In the several cases examined numerically and analytically, the escape rate is shown to agree with the proposed formula.

Journal Article↗
PubMed1983

Experimental study in rabbits of the antishock effect of anisodamine (654-2), and its mechanism of action.

The antishock effect of anisodamine (654-2) was observed in different kinds of experimental shock in groups of rabbits--due to late hemorrhage, superior mesenteric artery occlusion, and septic shock from peritonitis. The drug 654-2 significantly alleviated the progress of shock and increased the survival rate of the animals. The therapeutic effect of 654-2 was much better than that of other vasoactive drugs commonly used, such as norepinephrine, phenoxybenzamine, dopamine, and aramine. The antishock mechanism of 654-2 is probably partly due to its protective action on intestinal shock in preventing its effects becoming irreversible. The antishock action of 654-2 both by basic research workers and clinicians merits further study.

Animals↗
PubMed1976

Anal lesions complicating Crohn disease.

Of 503 patients with Crohn disease seen at the New York Hospital-Cornell Medical Center, 138 (28%) developed an anorectal abscess, anal fissure, or anal fistula during the course of their disease. In 9.3% of patients the anal lesion preceded the onset of intestinal symptoms by two weeks to 12 years. Patients in our series with large bowel disease were twice as likely to develop an anal lesion as were patients with small bowel disease. Likewise, patients with large bowel disease were twice as likely to have had an anal lesion as a presenting symptom. A patient with an anal lesion, however, was more apt to develop small bowel disease simply because the small bowel was a far commoner site of Crohn disease in this series. The cause of the anal lesions is still not clear. Specific evidence of Crohn disease was not found in histological examination of material from any of the patients.

Abscess↗
PubMedDate not supplied

Accuracy of phase-contrast flow measurements in the presence of partial-volume effects.

The accuracy of volume flow rate measurements obtained with phase-contrast methods was assessed by means of computer simulation and in vitro experiments. Factors studied include (a) the partial-volume effect due to voxel dimensions relative to vessel dimensions and orientation and (b) intravoxel phase dispersion. It is shown that limited resolution (partial-volume effect) is the major obstacle to accurate flow measurement for both laminar and plug flow. The results show that at least 16 voxels must cover the cross section of the vessel lumen to obtain a measurement accuracy to within 10%. Measurement accuracy also greatly depends on the relative signal intensity of stationary tissue and is better for laminar flow than plug flow.

Biophysical Phenomena↗
PubMedDate not supplied

Correction of partial-volume effects in phase-contrast flow measurements.

Because of the relatively small size of vessels and limited magnetic resonance (MR) imaging resolution, the accuracy of volume flow rate measurements is limited. A technique that corrects the partial-volume effect in volume flow rate measurements is presented. The technique uses small-phase-shift approximation, with the assumption that blood flow in the voxels at the boundary of the vessel is slow. With the proposed correction technique, the volume flow rate in partially occupied voxels is corrected on a voxel-by-voxel basis and the accuracy of flow measurements increases. Results are shown analytically and for MR phantom data.

Artifacts↗