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Biomedical subjects

C T Nelson

Publications and source records attributed to C T Nelson.

At least 19 recordsLinked to original sources
PubMed2001

Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection.

OBJECTIVE: To determine the ability of neonatal clinical, audiologic, and computed tomography (CT) findings to predict long-term neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection. METHODS: Longitudinal cohort study of children (n = 41) with symptomatic congenital CMV infection evaluated at birth and followed up with serial age-appropriate neurodevelopmental testing. The performance of birth characteristics as predictors of long-term outcome were determined, and clinical and CT scoring systems were developed and correlated with intellectual outcome. RESULTS: Microcephaly was the most specific predictor of mental retardation (100%; 95% CI 84.5-100) and major motor disability (92.3%; 95% CI 74.8-99). An abnormality detected by CT was the most sensitive predictor for mental retardation (100%; 95% CI 82.3-100) and motor disability (100%; 95% CI 78.2-100). A highly significant (P <.001) positive correlation was found between head size at birth and the intelligence/developmental quotient (IQ/DQ). Approximately 29% of children had an IQ/DQ >90. There was no association between sensorineural hearing loss at birth and cognitive outcome. However, children with sensorineural hearing loss on follow-up (congenital and late-onset) had a lower IQ/DQ (P =.006) than those with normal hearing. CONCLUSIONS: The presence of microcephaly at birth was the most specific predictor of poor cognitive outcome in children with symptomatic congenital CMV infection, whereas children with normal findings on head CT and head circumference proportional to weight exhibited a good cognitive outcome.

Cerebral Palsy↗
PubMed1998

The functionally and physiologically plastic adult auditory system.

The potential for functional and underlying physiological change in the adult auditory system is examined through review and evaluation of several sets of literature including auditory deprivation and recovery, auditory learning after hearing aid fitting, auditory abilities of normal listeners exposed to masking noise, and neural plasticity in the sensory and motor systems of animals. This tutorial review is meant for the reader who may be interested in auditory learning and who would like to have a summary and evaluation of the various findings to date. The focus of the review is the effect that various findings of auditory learning may have on hearing aid fitting and selection.

Adult↗
PubMed1997

Cytomegalovirus infection in the pregnant mother, fetus, and newborn infant.

Cytomegalovirus (CMV) is a common virus that infects persons of all ages, races, and backgrounds. Originally described as a rare cause of "cytomegalic inclusion disease," CMV is now known to cause a broad spectrum of illness in the fetus and newborn, with most infections being asymptomatic at birth. This article discusses the epidemiology and diagnosis of CMV infection in pregnant women, the fetus, and the newborn, including recent advances in antenatal diagnosis. In addition, the challenges of treatment and prevention of congenital CMV are explored.

Cytomegalovirus↗
PubMed1994

Test-retest reliability of the profile of hearing aid performance.

This study was designed to replicate the test-retest reliability and critical difference components of the Profile of Hearing Aid Performance (PHAP) as established by Cox and Gilmore (1990). Subjects were 18 experienced hearing aid users ranging in age from 62 to 74 years old. The initial and retest administrations of the PHAP were conducted with no rehabilitative treatment pertaining to hearing loss or amplification provided during the intervening period. The interval between the first and second administrations of the profile was 4-5 months. The mean test-retest difference scores obtained in this investigation were small, not unlike those reported by Cox and Gilmore (1990). Critical difference (CD) values closely approximated those of the previous study except for the Background Noise subscale and the Environment C scale. A pooled estimate of each standard deviation of test-retest differences was computed using data from both investigations. This resulted in critical differences considered to be more precise than the CD values derived from either study alone. Findings strongly support the utility of the PHAP as an effective tool for generating reliable information regarding self-perceived hearing aid performance.

Aged↗
PubMed1994

Activity of oral antibiotics in middle ear and sinus infections caused by penicillin-resistant Streptococcus pneumoniae: implications for treatment.

The increasing prevalence of intermediately and highly penicillin-resistant strains of Streptococcus pneumoniae is a problem worldwide. However, optimal management of patients with middle ear and sinus infections caused by resistant pneumococci has not been established. We performed agar dilution susceptibility studies on 71 strains of penicillin-resistant pneumococci (minimum inhibitory concentration (MIC), > or = 0.1 microgram/ml) recovered from middle ear and sinus cultures of Houston children against 13 oral antibiotics with the use of both established and newly proposed National Committee for Clinical Laboratory Standards susceptibility criteria. Of the 62 middle ear isolates 35 (56%) were intermediately resistant and 27 (44%) were highly resistant to penicillin. Of the 9 sinus isolates tested, 5 (56%) were intermediately resistant (MIC between 0.1 and 1 micrograms/ml) and 4 (44%) were highly resistant (MIC > or = 2 micrograms/ml) to penicillin. The MIC90 increased with increasing penicillin resistance for the antibiotics tested except for rifampin, ciprofloxacin, loracarbef, clindamycin and trimethoprim-sulfamethoxazole. None of the highly penicillin-resistant isolates was susceptible to loracarbef or trimethoprim-sulfamethoxazole. The MIC90 values for clindamycin and rifampin were similar for the intermediately and highly penicillin-resistant groups, and the number of susceptible isolates in each group remained greater than 90% for both antibiotics. Thirty-five isolates were resistant to erythromycin but susceptible to clindamycin, a susceptibility pattern distinctly different from that seen in South Africa and Europe, where clindamycin resistance parallels erythromycin resistance.(ABSTRACT TRUNCATED AT 250 WORDS)

Anti-Bacterial Agents↗
PubMed1976

Pemphigus: a 20-year review of 107 patients treated with corticosteroids.

We review 107 consecutive cases of pemphigus. The mortality for pemphigus vulgaris and pemphigus vegetans was 46% between 1949 and 1959 and 24% between 1960 and 1970. The overall mortality for all types of pemphigus was 32%. In the corticosteroid era, complications of therapy were the most frequent causes of death. Mortality and morbidity closely correlated with the corticosteroid dosage used to attain control. This dosage proved to be variable and could not be predicted at the outset in any given patient.

Adolescent↗