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Biomedical subjects

C T Liu

Publications and source records attributed to C T Liu.

At least 109 records · Page 6Linked to original sources
PubMed1976

Cardiovascular and vomiting responses to a lethal intravenous dose of staphyloenterotoxin A in rhesus monkeys.

Effects of a single intravenous dose of highly purified staphylococcal enterotoxin A (SEA; 0.5 mg/kg) were studied in conscious rhesus monkeys. The mean survival time for four of five experimental monkeys was 8.7 h. Vomiting, pallor, abdominal distension, occasional diarrhea and dehydration were observed. Tachycardia and sustained hypotension developed prior to death. During vomiting, transient hypertension was induced.

Animals↗
PubMed1976

Cardiovascular and renal functions in normal rhesus macaques.

Techniques on measurements of cardiovascular and renal functions in conscious rhesus macaques (Macaca mulatta) are described, and normal base line values are presented. The determinations included blood pressure, cardiac dynamics, total peripheral resistance, renal metabolism, renal concentrating capcity, acid-base balance, and renal handling of electrolytes.

Acid-Base Equilibrium↗
PubMed1976

Effects of DOCA on circulation, renal functions, body fluids and tissue electrolytes.

Desoxycorticosterone acetate (DOCA) was administered subcutaneously to 11 normal dogs (2 mg/kg/day) for 4 days. Few changes were observed in cardiovascular and renal functions except that the glomerular filtration rate was significantly increased. Total body water and plasma volume increased with a reduction of red blood cell volume. Hematocrit, plasma osmolality and total protein concentrations were decreased. The plasma K+ levels were lowered despite unchanged plasma concentrations of Na+, Ca++, Mg++, Cl- and phosphorus. The heart showed an increase in Na+ content and a decrease in K+, Ca++, phosphorus and total lipids. The skeletal muscle showed a decrease in Ca++ and an increase in Cl- and water content. The skin revealed a reduction of K+ and an elevation of Cl-. This study showed that a DOCA-induced depletion of K+ from skeletal muscle did not occur in normally fed dogs that did not receive a large sodium load.

Animals↗
PubMed1975

Changes in blood pH in rats after infection with Streptococcus pneumoniae.

Acid-base alterations in Streptococcus pneumoniae infection were studied in 80 male albino rats. Hematocrit and concentrations of plasma electrolytes, glucose, and total protein were also measured. At 3-h intervals throughout a 27-h study, four control and four infected rats were anesthetized with ether, and blood samples were taken. Arterial blood pH, Po2, and hematocrit increased in the infected group, whereas arterial Pco2, HCO3-, and venous Po2 decreased. Plasma K+ concentration increased slightly and glucose levels decreased in the infected rats as the sepsis progressed. No significant changes were observed in venous blood pH, HCO3-, and Pco2. Plasma Na+, Cl-, and total protein remained unchanged. The increase in arterial blood pH and decrease in arterial Pco2 and HCO3- indicated respiratory alkalosis, which was present in rats infected with S. pneumoniae.

Acid-Base Equilibrium↗
PubMed1975

Mechanisms of oral staphylococcal enterotoxin B-induced emesis in the monkey (38553).

Vomition is the most consistent response to oral SEB challenge in the monkey. The technique of cross-circulation clearly differentiates local neural phenomenon from humoral mechanisms. Our results support the theory that SED-induced vomition follows stimulation of local neural receptors in the gut. The evidence indicates no significant amount of enterotoxin absorption or stimulation of vomition by any centrally acting humoral mechanism.

Administration, Oral↗