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Biomedical subjects

C T Cho

Publications and source records attributed to C T Cho.

At least 37 records · Page 2Linked to original sources
PubMed1977

Synergistic effects of antiviral agents and humoral antibodies in experimental Herpesvirus hominis encephalitis.

Experimental Herpesvirus hominis encephalitis in 3-week-old Swiss mice was utilized to evaluate the antiviral effects of adenine arabinoside (ara-A), phosphonacetic acid (PAA), and humoral antibodies to H. hominis (HIG). Administration of ara-A, PAA, or HIG during the early phase of infection reduced the mortality rate of H. hominis encephalitis in mice. Combined administration of humoral antibodies with an antiviral agent (ara-A or PAA) resulted in an enhanced protection, accompanied by a decreased virus concentration in the brain tissues and a diminished tissue injury. The generality of this enhancing effect of humoral antibodies on the action of antiviral agents and its possible use in therapy of viral infections warrant further investigation.

Animals↗
PubMed1977

Interaction of adenine arabinoside and host defense factors in experimental infections due to Herpesvirus hominis.

The role of host immune functions in relation to the antiviral effects of adenine arabinoside (ara-A) and/or humoral antibodies in Herpesvirus hominis infection was studied in four different mouse models (newborn Swiss mice, three-week-old Swiss mice, athymic nude [nu/nu] mice, and phenotypically normal [nu/+] littermates of nude mice). Although the overall beneficial effects afforded by the administration of ara-A and/or humoral antibodies were similar, the degree of protection varied among the four host systems. The data indicate that host defense factors play an important role in modulating the effect of humoral antibodies and/or an antiviral agent. Combined use of ara-A and humoral antibodies resulted in enhanced protection against H. hominis infection. Our data suggest that control of viral infection, particularly in compromised hosts, may require chemoimmunotherapy.

Animals↗
PubMed1977

Pulmonary involvement with cytomegalovirus infections in children.

Among 40 hospitalized infants and children with cytomegalovirus infection, 14 (35%) had interstitial pneumonitis, 4 (10%) had wheezing or tachypnoea but without x-ray evidence of classical interstitial pneumonia, the remaining 22 (55%) were free of pulmonary involvement. Most patients had tachypnoea and nonproductive cough of varying durations: those with underlying pulmonary pathology tended to have persistent and prolonged respiratory symptoms. Mortality and severity of the lung disease were related to the underlying immunodeficiency or concomitant pulmonary process.

Adolescent↗
PubMed1977

Gonococcal infections in young children. Studies on the social, familial, and clinical aspects of 11 instances.

Of 43 youngsters with gonorrhea, 11 were under 10 years of age. These 11 had in common atypical clinical presentation, marital disharmony of the parents, crowded living conditions; some had been abused sexually. Management of gonorrhea in such young children may require a concerted effort by a team of medical, social, and legal personnel to meet the needs of this unique entity.

Adolescent↗
PubMed1977

Measurement of antibodies to Herpesvirus hominis by indirect immunofluorescent antibody method.

Antibodies to Herpesvirus hominis (HVH) were evaluated by indirect immunofluorescent antibody (FA) method. Frozen sections of HVH infected mouse brain provided antigens for FA staining. Our data indicate that indirect FA staining is a rapid, sensitive, and reproducible method for measurement of antibodies to HVH. Indirect FA method can be applied as an additional tool for the measurement of antibodies to HVH and can be applied for epidemiological survey of HVH infections.

Adolescent↗
PubMed1976

Persistent pleocytosis in bacterial meningitis.

Persistent pleocytosis of greater than 60 white blood cells/mm3 was commonly seen in children adequately treated for bacterial meningitis. It occurred in 13 of 21 (62%) children with Hemophilus influenzae meningitis and in 2 of 9 (22%) with pneumococcal meningitis. Pleocytosis alone cannot be used as an indication of prolonging therapy; significance of persistent pleocytosis is not known.

Adolescent↗
PubMed1976

Synergistic antiviral effects of adenine arabinoside and humoral antibodies in experimental encephalitis due to Herpesvirus hominis.

The antiviral effects of humoral antibodies and adenine arabinoside on encephalitis due to Herpesvirus hominis were studied in three-week-old mice. Exogenously administered antibodies to H. hominis, of rabbit or human origin, significantly reduced morbidity and mortality rates from H. hominis encephalitis if enough antibodies were given during the early phase of infection. Adenine arabinoside could also modulate the pathogenesis and reduce the mortality rate in mice with H. hominis encephalitis. Simultaneous administration of adenine arabinoside and human immune globulin resulted in an enhanced protection against H. hominis encephalitis. This increased protection was manifested by a significant reduction of mortality rate, a decrease in concentration of virus, and a lessening of histopathologic damage in the brain tissues. Mechanisms involved in the enhanced protective effects were not well defined. The use of adenine arabinoside plus human immune globulin did not completely suppress viral replication. Therefore, host recovery was probably mediated through (1) partial suppression of viral replication by adenine arabinoside, (2) neutralization of cell-free virus by antibodies, and (3) collaboration of antibodies with other host resistance factors (e.g., complement, leukocytes, nonimmune effector cells, etc.). Our data suggest that control of severe H. hominis infection may require the combined use of an antiviral agent and humoral factor and, perhaps, enhancement of host responses by other means.

Animals↗
PubMed1975

Immunofluorescent staining for the measurement of antibodies to Herpesvirus hominis.

Frozen sections of Herpesvirus hominis-inoculated mouse brain provide excellent antigens for indirect immunofluorescent staining of antibodies to H. hominis in serum. Indirect immunofluorescent staining is a rapid, sensitive, and reproducible method for the measurement of antibodies to H. hominis. The method can be applied to the clinical and epidemiological studies of H. hominis infections.

Animals↗
PubMed1974

Non-immunological precipitation of serum by sodium dodecyl sulfate in agar diffusion.

Marmoset serum or serum of other species of animal may react with sodium dodecyl sulfate and forms nonspecific precipitin lines in agar diffusion. The protein detergent complexes are not readily dialyzable. Therefore precipitin lines derived from studies that use sodium dodecyl sulfate-treated antigens in agar diffusion must be interpreted with caution.

Agar↗