Biomedical subjects
C Svalander
Publications and source records attributed to C Svalander.
Liquid formaldehyde in catecholamine studies. A new approach to the morphological localization of monoamines in the adrenal medulla and the supraoptic nucleus of the rat.
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Aminopeptidase activity in foetal rat parathyroids and its inhibition by vitamin D-induced hypercalcaemia in the mother rat.
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Immune deposits in oral mucosa, skin and kidney in patients with systemic lupus erythematosus.
Biopsies were obtained simultaneously from normal oral mucosa, sun-protected and sun-exposed skin in patients with suspected or diagnosed systemic lupus erythematosus, in order to compare the deposition of immunoproteins. In patients with renal involvement a kidney biopsy was also studied. Immunofluorescence findings at the connective tissue-epithelial junction (lupus band test) showed a good correlation between keratinized oral mucosa and sun-protected skin in 18 sets of biopsies while sun-exposed skin frequently showed more immune reactants. No close connection could be found between the deposition of immune reactants in skin/mucosa and kidney. It is concluded that diagnostic use of the lupus band test performed on normal mucosa has the same value as that on sun-protected skin.
A clinical attempt to avoid hyperacute rejection by F (ab') 2 organ pretreatment.
An attempt was made to, in a controlled study, avoid hyperacute rejection by pretreatment of a renal graft pepsine digested anti-donor antibodies. It turned out to be unsuccessful, but there were some indications that the chain of events that leads to the destruction of the graft was delayed for some hours. There may be several reasons for this failure but we think it is possible to improve this method even if its importance in clinical use is still doubtful.