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C Susanne

Publications and source records attributed to C Susanne.

69 records · Page 4Linked to original sources
PubMedDate not supplied

Nutritional status by socioeconomic level in an urban sample from Bilbao (Basque Country).

Anthropometry, records of food intake, and bioelectric impedance were gathered from a sample of 297 adults of both sexes who lived in marginal districts in the town of Bilbao and benefited from a program of social assistance. This survey aimed to determine present nutritional status and to ascertain the relationship between food intake and nutritional conditions. A comparative evaluation of anthropometry and food intake was then carried out using a reference from the Basque Country and a control sample from the same area but from better-off nutritional and socioeconomic conditions. Males from low socioeconomic status (SES) displayed lower heights and weights compared to the local reference and control sample. They showed higher skinfold thickness than males in the local reference but lower thicknesses than those in the control sample. All anthropometric variables, except height, were higher in women of low socioeconomic status compared to the local reference and control sample. Low socioeconomic males had lower estimated percentage of body fat than the control sample, while females showed the opposite pattern. On the other hand, estimates of food intake in males did not reveal great differences among samples from different socioeconomic backgrounds, while low SES females had greater intakes of food than the better-off control sample. Estimated zinc intake showed differences by SES in both sexes.

Adult↗
PubMedDate not supplied

Comparative in vitro cytogenetic studies in mercury-exposed human lymphocytes.

As part of a long-term cytogenetic research project on mercury, we studied the in vitro clastogenic capacity of HgCl2 and CH3HgCl as well as their influence on chromosome segregation by means of a computer-aided chromosome distribution study in metaphase plates. As in other in vitro studies published elsewhere, we exposed human peripheral blood lymphocytes to different concentrations of the mercury compound during a limited period of the pre-DNA synthetic stage (G1-S) or from that stage up to mitosis (G1-M). For both exposure periods and both mercury compounds we observed a rather important clastogenic effect as well as a dissociation of the (normally highly associated) acrocentrics. The results do indicate, in conjunction with previously published data, that mercury compounds alter the chromosome segregation at lower concentrations than those observed for clastogenicity. Moreover, the effects on chromosome segregation are not necessarily due to binding to spindle proteins. Binding to--and inactivation of RNA polymerase I may for example be another mechanism of action which is more important for the inorganic form of mercury than for the organic form.

Adult↗
PubMedDate not supplied

Variation in bone mineral density in adults in Poland: age and sex differences.

The decline of mineral bone density with age can lead in more extreme cases to osteopenia and osteoporosis, and is therefore one of the aspects of ageing with great medical and social significance. With this idea in mind a study of age changes in the trabecular and, separately, the cortical bone density of the radius was carried out in 1218 females and 405 males, aged 22 to 60 years, all occupationally active inhabitants of the city of Wroclaw, Poland. The technique used was the peripheral Quantitative Computed Tomography (pQCT). It was found that in females bone densities remain relatively stable throughout the period between 22 and 40 years. They then begin to decline slowly, with a rapid decline after the age of 55. A distinctly different pattern was found among males, with bone densities reaching peak values, markedly higher than those in females, in the third decade of life. After this age the bone density values begin to decline at a rapid rate, so that by the age of 60 years mean trabecular and cortical densities in males have decreased to levels almost equivalent to females of equal age. In view of the small size of the male samples, especially in the older age classes, the above results should be treated with caution and confirmed using larger samples.

Adult↗
PubMedDate not supplied

Analysis of sibling resemblance in anthropometric somatotype components.

We analysed the Heath-Carter somatotype familial resemblance degree in a sample of 1350 siblings (685 males and 665 females) from 634 nuclear families in the province of Biscay (Basque Country, Spain). Sibling correlations were estimated according to maximum likelihood procedures for endomorphy, mesomorphy, ectomorphy and somatotypical attitudinal distance (SADi), after having adjusted for age, sex and the two other components (Model I), and after taking into account several environmental variables shared by all members of each sibship (Model II). All sibling correlations of the somatotype components were significant, tending to be higher in the case of mesomorphy than in the case of endomorphy. Same-sex siblings (BB and SS) displayed significant mesomorphic and ectomorphic resemblances, but in the case of endomorphy, sisters (SS) revealed relatively low correlation compared with brothers (BB). The sex of sibs had a significant influence on correlations of mesomorphy, but not on the other two components. Further control of socio-familial variables such as the father's occupation and education, and the sibship size, resulted in lower mesomorphy correlation coefficients, but had no effect whatsoever on the other two components. SADi correlations were very low and not significant, indicating high degrees of dispersion in the individual somatotypes of the sample.

Adolescent↗
PubMedDate not supplied

The inverse relationship between bone status and blood pressure among Polish men.

PRIMARY OBJECTIVE: An evaluation of relationships between bone density and blood pressure in healthy men. RESEARCH DESIGN: A cross-sectional population-based survey. METHODS AND PROCEDURES: An ethnically homogeneous sample of 208 men, aged 35-63, healthy and occupationally active inhabitants of the city of Wroclaw, Lower Silesia, Poland were studied. Trabecular, cortical and total bone mineral content (BMC) at the ultra-distal radius of the non-dominant hand were assessed by peripheral Quantitative Computed Tomography (pQCT: Stratec 960 apparatus). Body mass index (BMI) was used as a measure of general obesity. Systolic and diastolic blood pressure (BP) were measured using an MPC-350 sphygmomanometer. Multiple linear regression was used to evaluate the relationships between BP and BMC. A two-way analysis of covariance was carried out to test for the significance of inter-group differences in BMC with regard to age and BP with BMI as a contiuous covariable. Multiple logistic regression was used to verify whether some select factors (age, BMI, systolic and diastolic BP) could significantly predict male bone status. RESULTS: Systolic BP was not related to bone status at the ultra-distal radius. There were no differences in any BMC between systolic hyper- and normotensive subjects. Additionally, systolic hypertension did not affect the probability of an occurrence of male osteopenia (independently of age and BMI). In contrast, there were significant negative relationships between diastolic BP, and trabecular and total (but not cortical) BMC (even when controlled for age and BMI). Moreover, diastolic hypertensive men had reduced BMC at the ultra-distal radius when compared with normotensive subjects. It is noteworthy that Polish men of diastolic BP exceeding 90 mmHg had an approximately 1.50-fold increased relative risk of being osteopenic when compared with normotensive subjects (even when controlled for age, BMI and systolic BP). CONCLUSIONS: In the light of the inverse relationship between BMC and diastolic BP, Polish men with elevated diastolic BP seem to be more prone to the excessive age-related bone loss.

Adult↗
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Familial resemblance for the age at menarche in Basque population.

A cross-sectional sample from Biscay province (Basque Country, Spain) composed of 296 subjects from 143 nuclear families was analysed. The aim of this research was to study familial resemblance for the age at menarche and to investigate the influence that BMI, fatness and several socio-familial variables have on the menarcheal age. The influence of these variables on the degree of similarity of mother-daughter and sister-sister pairs for the age at onset of menstruation will be determined. Mean ages at menarche of mothers estimated by retrospective methodology (12.88 years, SD = 1.57) and daughters assessed by probit analysis (12.34 years. SD= 1.00) showed no statistically significant differences. Mother-daughter and sister-sister correlations increased after controlling for BMI, fatness and several socio-familial variables (0.25 vs 0.36 and 0.28 vs 0.44, respectively). The results revealed the importance of BMI, fatness, socio-economic level and the number of people living together in the household on menarcheal age and on the estimation of correlations. However, no influence from sibship size (possibly because this variable is a part of the people living together in the household) nor from birth order of the subjects was observed.

Adolescent↗
PubMedDate not supplied

Genetic and environmental sources on familial transmission in Basque families. II. Stature, weight and body mass index.

PRIMARY OBJECTIVE: The present research analyses a cross-sectional sample of 359 individuals (107 fathers, 107 mothers, 71 sons and 74 daughters) in 107 nuclear families from the Basque Country (Spain). The aim was the estimation of both transmissible and non-transmissible components acting on familial resemblance for stature, weight and body mass index (BMI). METHODS: Standardized data of each generation and sex were adjusted to a BETA model of path analysis independent of sex effects, allowing the possibility of differentiating between transmissible (genetic and cultural) and non-transmissible (environmental) components acting on the observed phenotypic variance in Biscayan offspring. RESULTS: The results supported the full model of familial transmission for the three variables, in addition to other reduced models that gave rise to transmission effects regardless of any influence from the siblings' shared environment on the environmental transmitted component from their parents (b = 0), and without genetic effects on the phenotype (h = z = 0). The most parsimonious model was accepted for weight and rejected for stature and BMI. The correlations existing between children and their mothers were higher than those with their fathers. CONCLUSION: The results confirmed the hypothesis of maternal effects influencing the inheritance of stature.

Adolescent↗
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Age trends of sibling resemblance for height, weight and BMI during growth in a mixed longitudinal sample from Sarsuna-Barisha, India.

BACKGROUND: Even though some studies have considered that sibling resemblance remains constant throughout the life cycle, several investigations emphasize the importance of age and its interactions with genetic and environmental factors in determining sibling similarity in several bodily traits. In fact, the study of age changes in familial resemblance is of great importance for the analysis of certain sources of variation observed in growth processes. AIM: The study examined sibling resemblance for height, weight and body mass index (BMI) in a mixed longitudinal sample from West Bengal, ages 2-19 years, in order to analyse the variations with age of the sibling resemblance for these phenotypes during growth. SAMPLE AND METHODS: Two hundred and forty-five brothers and 213 sisters from 138 middle-class nuclear families living in a semi-urban area of South Kolkata, India were analysed. The analysis of sibling resemblance was performed through correlations estimated by the maximum-likelihood method. The patterns of different trends of sibling resemblance with age were examined by fitting a cubic non-linear regression to the observed correlations. RESULTS: The results show clear variations with age in the sibling resemblance for the traits height and weight, though to a lesser extent for BMI. In general, we found the highest correlation values during the period of infancy, a remarkable decrease during puberty, and a trend of increase towards the end of the growth cycle. CONCLUSION: The study confirms the effect of age on the degree of similarity among siblings for height, weight and BMI in the sample. The sharp decline of correlation at adolescence can be interpreted in terms of the individual variation in age of reaching the adolescent growth spurt.

Adolescent↗
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A comparative study of the fit of four different functions to longitudinal data of growth in height of Belgian girls.

We have fitted Preece-Baines model 1, double logistic, logistic and Gompertz functions to longitudinal data on the growth in height of 35 Belgian girls, followed from birth to 18.0 years. The Preece-Baines model 1 showed significantly lower residual mean squares than the double logistic function, when fitted to data beyond the age of 1.0 year. The former model was also most robust towards variations in the lower age bound by the subject's data series and always described the adolescent spurt better than the latter. Both models fitted the data badly when measurements before the age of 1.0 year were included, and they usually estimated the point at take-off too early. Over the adolescent cycle, only, the logistic function fitted our data slightly better than the Gompertz function, with significantly lower pooled residual mean squares, though a slightly worse performance in the runs-test.

Adolescent↗
PubMedDate not supplied

Testing for the presence of genetic variance in factors of face measurements of Belgian twins.

Factor analysis with VARIMAX rotation was used to analyse 15 face measurements in Belgian same-sexed twins, aged 18-25 years: 39 dizygotic and 57 monozygotic male pairs and 42 dizygotic and 67 monozygotic female paris. According to Christian's model, we used the ratio of the within-mean squares of dizygotic and monozygotic pairs to test for the presence of a genetic component in the variance of the facial dimensions and of all the rotated factors were statistically significant (P less than 0.05), suggesting a genetic component in the variance. The probabilities of the F values were generally lower in males than in females. The factor analysis yielded five main factors of which three were well separated: face height, ear size and lips. The two others were breadth factors, but were less clearly defined, probably due to a bad selection of variables. A comparison of the F values of the factors with those of their contributing variables seemed to indicate that well-defined factors may better describe genetically determined structures than the original variables can.

Adolescent↗
PubMedDate not supplied

Genetic variance in the pattern of the growth curve for height: a longitudinal analysis of male twins.

Genetic aspects of the pattern of growth and of short-term variations in growth velocity for height were studied in a sample of 44 MZ and 42 DZ twin pairs from the Wroclaw Longitudinal Twin Study. The data consists of serial measurements of height, taken between 8.5 years of age and adulthood. The intra-pair resemblance of the pattern of attained height was quantified by means of the average Euclidean distance coefficient and the coefficient of shape difference, calculated on the raw height-for-age data. Comparison of these resemblance coefficients between the two types of twins indicated that the growth curves of MZ twins are closer to each other, and more similar in shape, than those of DZ twins. The shape of the growth curve was further characterized by a set of biological parameters, derived from Preece Baines model I (PB) fitted to each subject's serial growth data. Genetic analysis of these parameters, according to the model of Christian, Won Kang and Norton (1974), revealed a strong genetic component in the variance of size at particular milestones in the growth process (height at take-off, at peak velocity and at adulthood), and also in the timing of the growth process (age at take-off and at peak velocity). Height velocity at take-off and peak height velocity were also strongly genetically determined. Finally, short-term variations in growth velocity were analysed on the basis of the profiles of the residuals, obtained by the PB fits to each subject's serial measurements of height. Resemblance coefficients were calculated for the profiles of residuals. The results revealed a significantly greater similarity of profile shapes of the residuals in MZ twins than in DZ twins, strongly suggesting that there is a genetic component in the short-term variations of growth velocity.

Adolescent↗
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Socioeconomic factors and growth during childhood and early adolescence in Jena children.

The influence of socioeconomic parameters (number of children in the family, birth order of subject, professional status of the father, education of the mother) and background characteristics (birth length, birth weight and age of the mother at birth of the child) of growth in body height in children from 4 to 12 years of age was investigated. The analysis is based on data from a longitudinal growth survey, which started with 207 children (98 males and 109 females) from Jena (Germany) in 1985. Multiple regression analysis was used to estimate the degree of relationship between height and the social or background factors. In this study no differences in growth between children of different social groups were found. Variation in height of girls was mainly affected by the biological factor length at birth of the child.

Adolescent↗
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Age variations in sibling correlations for height, sitting height and weight.

Familial correlations for height, sitting height and weight have been studied in a sample of 1278 siblings for the Biscay province (Basque Country), aged 4+ to 24+ years. The data have been internally standardized according to sex and age of individuals. The degree of resemblance among sibling has been expressed by intraclass correlation coefficients. The total sample has been divided into three age categories: < 12 years, 12-15 years, and > or = 15 years, in order to examine the effect of age on sibling correlations. In general, changes with age have been observed: sibling correlations for height show a clear upward trend through the considered growth period, reaching a value of 0.48 from 15 years of age. Intra-correlations for weight show a slight downward trend with age. Sitting height shows a rather low correlation before 12 years of age, but equally high values in the other two ranges of age (0.48 and 0.47, respectively). This study confirms that the sibling resemblance for the analysed trait fluctuated through the growth period--height and sitting height showing similar patterns of variation with age--and that, after puberty, the degree of genetic determination is higher for bone measurements than for weight.

Adolescent↗
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Factor analysis and somatotyping, are these two physique classification methods comparable?

The aim of this study was to investigate the correspondence of physique structures estimated by the Heath-Carter anthropometric somatotyping method and a factor analysis based on the same set of 10 variables used by Heath-Carter. The investigation was carried out on a group of 200 healthy young adults of 20 years of age who were students of physical education. The mean somatotype was 2.7-4.6-3.0 for the males and 3.3-3.4-3.1 for the females. The 73% of the total variance in males and 75% in females were represented by three factors. They were identified as muscular, fatness and skeletal factors in the males, and in the females as muscular-trunk fatness, skeletal and limb fatness factors. A PCA gives different results depending on the measurements used for the calculation. The same set of variables as for the somatotyping method were used intentionally to extract the PCA factors and to evaluate the possible correspondence between these factors and the Heath-Carter components. On the basis of the correlation between the factors and the somatotype components, one can conclude that there is: (1) a high correspondence between endomorphy and fatness factors in both sexes; (2) that mesomorphy correlated positively with the muscular factor in males and negatively with the skeletal factor in both sexes; and (3) that ectomorphy was highly positively correlated with the skeletal factor and negatively with the other two factors in both sexes. Factors and somatotype components do not correspond exactly which leads to the following conclusions: (1) The three somatotype components cannot be identified as orthogonal factors in a factorial analysis based on the same measurements as for the somatotype, e.g. the ectomorphy component is not an independent factor in males or in females; (2) The muscle measurements and bone width used to estimate mesomorphy in somatotyping scored in two independent factors; and (3) The factor structure of the 10 measurements was sex dependent.

Adult↗