[Does prolactin play a role in pubertal maturation?].
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Adolescent↗
Biomedical subjects
C Sultan
Publications and source records attributed to C Sultan.
[Normal erythropoiesis and its regulation].
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Androgens↗
[Acquired idiopathic sideroblastic anemia (author's transl)].
The authors consider the clinical and biological data of Acquired Idiopathic Sideroblastic Anemia (AISA). The physiopathology of the syndrome is discussed; the relationships between pathologic sideroblastosis, dyserythropoiesis and ferrokinetic modifications are pointed out. The associated abnormalities of granulocytic and megacaryocytic series linked AISA to other myelodysplasia.
Anemia, Sideroblastic↗
[Persistant pubertal gynecomastia. Biological study (author's transl)].
17 cases of peristant pubertal gynecomastia (which differs from physiologic breast enlargement by their volume and duration) were studied. Plasma estrogens and urinary phenol steroids excretion were found higher than in normal boys. The main biological finding in these subjects was a decrease of the plasma testosterone/estradiol ratio, and a moderate but transient increase in plasma prolactin. LH and FSH were within the normal range. In the mammary tissue, no estrogen receptor was detectable and aromatase activity was in the same range as in adipose tissue. Pathological examination showed a simulataneous proliferation of galactophoric and fibroblastic stroma. Thus, persistant pubertal gynecomastia could be related to an elevated sensitivity of the mammary tissue to a moderate increase of plasma estrogens. Such a sensitivity could be due to an insufficient masculinization of the mammary anlage during the intra-uterine life.
Adolescent↗
[Human sex skin fibroblast cultures : a useful tool for diagnosis of male pseudohermaphroditism due to target organ unresponsiveness to androgens (author's transl)].
Sex skin fibroblast cultures were reported to constitute a fair model for studying male pseudohermaphroditism (MPH) due to target organ unresponsiveness to androgens. Using this technique, we made the diagnosis of MPH due to steroid 5 alpha-reductase deficiency, complete or partial androgen insensitivity. This technique gave the opportunity to describe an unstable form of 5 alpha-reductase and a thermolability of androgen receptors responsible for MPH. This method permitted a better understanding of disorders of male sex differentiation.
Androgens↗
Mediation by an androgen receptor of the stimulatory effect of testosterone on the growth of a fibrosarcoma in the rat.
We studied the effect of testosterone on the growth of a 20- methylcholanthrene-induced transplanted fibrosarcoma and assayed androgen receptors in this tumor. The effect of an antiandrogen in male rats and the comparative tumor growth in females confirmed the androgen sensitivity. A synthetic androgen that strongly binds to the androgen receptor was used to characterize the binding activity in nuclear extracts of tumor. Scatchard analysis showed that the dissociation constant of the hormone receptor complexes (Kd) was 26 +/- 2 nmol/l and the number of binding sites was about 95 +/- 12 fmol/mg of protein. The hormone-receptor complexes sedimented in the region of 3.7 S.
Animals↗