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Biomedical subjects

C Stern

Publications and source records attributed to C Stern.

At least 73 records · Page 4Linked to original sources
PubMed1976

Immunoglobulins M and D as antigen-binding receptors on the same cell, with shared specificity.

Antigen-binding cells specific for Type 3 pneumococcal polysaccharide were detected among normal human peripheral blood lymphocytes, tonsillar lymphocytes, and umbilical cord blood lymphocytes. By using mu and delta-specific antiserum it was shown that some specific antigen-binding cells simultaneously expressed both IgM and IgD on their surface. Both classes on individual cells were able to bind the same antigen, suggesting that the variable regions of each immunoglobulin class, when present on the same cell membrane, are coded by the same V gene.

Antigens, Bacterial↗
PubMed1971

On cell lethals in Drosophila.

Somatic crossing over in flies heterozygous for a dominant Minute mutant may result in two cells, homozygous for wild type and Minute, respectively. If both cells took part in development, a twin spot of two genotypes, different from the rest of the body, would result. Two-hundred wild type spots were found, none of which was accompanied by an adjacent twin spot homozygous for Minute. The absence of these spots shows that their cell lethality is not overcome by transport, including diffusion, across a few cells of gene-dependent material from the neighboring cells which carry one or two wild type alleles of Minute.

Alleles↗