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Biomedical subjects

C Stark

Publications and source records attributed to C Stark.

At least 55 records · Page 3Linked to original sources
PubMed1994

Run an emergency helpline.

Telephone helplines are an effective way of dealing with health related incidents in which large numbers of people need personal counselling or information for reassurance or case finding. Helplines often have to be set up at short notice, which is labour intensive and makes recruitment of appropriate staff difficult. They should ideally be part of local emergency planning resources. Doctors need to be included in the team organising the helpline to ensure that staff are properly briefed, to determine what data need to be collected, and to deal with specialised queries.

Counseling↗
PubMed1994

Violence at work.

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Emergency Service, Hospital↗
PubMed1994

The relationship between an increase in beta-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances.

Forty-four healthy volunteers were given either amoxycillin (ten subjects), cefpodoxime proxetil (ten subjects), ceftibuten (14 subjects) or cefuroxime axetil (ten subjects) orally for 7-10 days, in order to study the ecological effects on the intestinal microflora. In all three groups receiving oral cephalosporins there was a significant increase in beta-lactamase activity during administration (P < 0.05). There was also an inverse correlation between enzyme activity in faeces during administration compared with the concentration of drug in the intestines and the level of ecological disturbance in the normal intestinal microflora. In volunteers given amoxycillin, only small alterations in the faecal microflora were observed although overgrowth by new amoxycillin resistant enterobacteria occurred in all volunteers. There was an overgrowth of enterococci and yeasts during treatment with cefpodoxime proxetil, ceftibuten or cefuroxime axetil, whereas the numbers of enterobacteria were reduced. Colonization with resistant enterobacteria did not occur, but 14 of 34 subjects receiving oral cephalosporins were colonized by Clostridium difficile. Side-effects were mild and not associated with the ecological alterations in the intestinal microflora.

Administration, Oral↗
PubMed1993

Applied relaxation training in the treatment of genital herpes.

Four individuals with frequent recurrences of genital herpes simplex virus (HSV) were trained in Applied Relaxation (AR). Participants included in the research had been diagnosed with herpes at least 1 year prior to the study, experienced six or more outbreaks annually, and were not taking antiviral medications. The experiment employed a multiple baseline across subjects design. Participants maintained daily diaries of the frequency, duration and severity of herpes activity from baseline until a minimum of 3 months posttreatment. Treatment consisted of 10 individual AR sessions. Pretraining and posttraining frontalis electromyographic activity measures of subjects' ability to relax during rest and to apply the relaxation skill during stressful role plays were obtained. All subjects reported pretreatment to posttreatment reductions in herpes frequency. These changes were statistically significant across all subjects as a group and individually for three of the four subjects. These results suggest that AR is an effective technique for reducing recurrent HSV infection.

Adult↗
PubMed1990

Fluoride content of bottled waters: implications for dietary fluoride supplementation.

Increase in the popularity of bottled water in the Metropolitan Houston area prompted this investigation about the fluoride content of bottled waters, since bottled water likely substitutes tap water for drinking water used by adults as well as infants in many households. Results from this study indicate that the fluoride content of most of the bottled waters are well below 0.3 ppm, a level at which dietary fluoride supplementation is recommended even for infants under two years of age. The importance of knowledge of water fluoride content in dietary fluoride prescription for pediatric patients is discussed.

Fluorides↗
PubMed1988

Multichannel intracranial recording device using a color imaging brain mapping system.

A procedure is described for the manufacture and use of a multichannel (up to 20) intracranial recording device. Electrodes are arranged in a horizontal plane, and can be controlled by a conventional microdrive. Data from multiple channels are visualized and analyzed utilizing a commercially available color imaging brain mapping system. Potential research applications include studies of neural generators of evoked responses through the simultaneous recording of intracranial and scalp potentials.

Animals↗
PubMed1987

Temazepam abuse.

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Anti-Anxiety Agents↗
PubMed1987

Quantification of coronary artery bypass flow reserve in dogs using cine-computed tomography.

Routine coronary angiographic assessment of bypass graft patency does not allow quantification of bypass graft flow reserve. This study was designed to evaluate the use of cine-computed tomography (cine-CT) to determine relative bypass graft flow velocities and flow reserve. Saphenous vein grafts from the left innominate to the midleft circumflex coronary artery were placed in 5 dogs. The proximal portion of the left circumflex was then ligated. A 20-mHz Doppler probe to assess graft flow velocity, a cuff-type vascular occluder to provide variable graft occlusion, and an infusion line for selective drug administration were placed at the midgraft position. Electrocardiographically triggered scans were performed at levels of the aortic root and cardiac base following bolus inferior vena cava contrast administration. Continuous recordings of Doppler velocity and aortic pressure and intermittent measurements of cardiac output were obtained throughout the studies. Selective increases and decreases in coronary artery bypass graft flow velocity from control were performed using combinations of intragraft adenosine and/or variable graft occlusion. Simultaneous contrast clearance curves were generated from a region of interest in the ascending aorta and in the coronary artery bypass graft. Subsequent determinations of a parameter, delta PT (the time difference between peak opacification in the aorta and the bypass graft), were found to highly correlate with individual values of relative coronary bypass graft flow velocity (r = 0.74-0.97, n = 54). This study suggests that cine-computed tomography can be used to noninvasively quantify relative bypass graft flow velocities in individual dogs and eventually in patients.

Animals↗