[Esophageal motor disorders in epiphrenic esophageal diverticula].
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Biomedical subjects
Publications and source records attributed to C Stanciu.
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An endoscopic and histopathologic observation made on 152 cases with gastric symptoms occurring 5-35 years of free interval after gastric resection revealed a gastric stump carcinoma in 14 (9 per cent) of the cases. Research pointed out that previous duodenal ulcer prevailed as compared to the gastric one, and the stomal located carcinomas co-existed with severe dysplasia of the gastric mucosa in six cases.
ECG changes were followed up in 69 patients under continuous electrocardiographic monitoring before, during and after esophago-gastro-duodenoscopy (EGD). Of these 32 (46.5%) had ischemic heart disease (IHD). One or more varied abnormalities including supraventricular or ventricular ectopic beats, sinus tachycardia or sinus bradycardia, intermittent right or left bundle branch block, S--T segment depression (and increased preexisting S--T segment depression), T wave flattening or inversion appeared during EGD. Only one patient with IHD developed anginal chest pain during endoscopy. Despite the high incidence of recorded rhythm abnormalities, these were transient, and no treatments were needed. However, it seems advisable to have resuscitation equipment and emergency drugs available during EGD, particularly when it is performed in patients with IHD.
Twenty four-hour continuous recordings of gastric and duodenal motor activity were obtained in 12 normal subjects. A regular, cyclical variation in gastro-duodenal motility, consisting of periods of intesnse activity for 15--30 minutes alternating with periods of almost complete quiescence during the following 30--90 minutes, was noted in all subjects. All wave types previously described in short term studies were observed. Antral and duodenal activity were often linked, but there were many occasions when either occurred independently. Motor activity while the patient slept differed little from the waking pattern. There was no consistent motility pattern which could be associated with the subjects' hunger sensation. Eating was followed by a significant increase in duodenal motor activity which has not been previously described; the authors assume it to be due to endogenous gastrin release.
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In order to study the effect of hypokinesia on rats' small intestine biopotentials it was first necessary to characterize it. Biopotentials were recorded by intracellulary microelectrodes from oral and caudal segments of the small intestine. The morphology of rat's small intestine biopotentials differs from that of other species (man, cat, rabbit, dog, e.a.) the slow waves being smaller and the frequency of basal electrical rhythm higher (approximately 31.23 c/min oraly and approximately 24.50 aboraly), and by waxing and waning waves that are more frequently encountered suggesting a greater number of plateaus potentials. Spike potentials are inscribed on the descending slope of the slow waves but delayed in each successive wave with a regular interval. Hypokinesia obtained by introducing rats in small cages for two weeks, increases the slow waves amplitude. Frequency of basic electric rhythm and other parameters are not specifically changed.
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