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Biomedical subjects

C Soria

Publications and source records attributed to C Soria.

At least 253 records · Page 14Linked to original sources
PubMed1975

Analysis of a fibrin formation abnormality in a case of multiple myeloma.

Studies were performed to analyse the inhibitory effect of a myeloma globulin (IgG) on fibrin formation. This inhibitory activity was very intense and caused a severe bleeding disorder which proved fatal. The isolated myeloma globulin inhibited all three stages of fibrin formation: the proteolytic action of thrombin on fibrinogen, the aggregation of fibrin monomers and the stabilization of fibrin by cross-linkages in the gamma and alpha chains. Purified factor XIII, even in excess, previously activated by the addition of thrombin and calcium, did not correct this defect in cross linking. Our results suggest that this myeloma globulin induced a blockage of some receptors near the cross linking sites.

Blood Coagulation Tests↗
PubMed1974

Analysis of an autoimmune antibody (IgM class) in a case of chronic lymphocytic leukaemia.

A case of an acquired circulating anticoagulant occurring in a patient suffering from chronic lymphocytic leukaemia with haemolytic anaemia and autoimmune disorders has been reported. The anticoagulant was found to belong to the IgM class. Coagulation studies show that this anticoagulant inhibits the reaction between human prothrombinase andfactor II.

Anemia, Hemolytic↗