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Biomedical subjects

C Skinner

Publications and source records attributed to C Skinner.

At least 73 records · Page 4Linked to original sources
PubMed1983

Dysphonia caused by inhaled steroids: recognition of a characteristic laryngeal abnormality.

Nine of 14 asthmatic patients who presented with persistent dysphonia while taking inhaled corticosteroids had a bilateral adductor vocal cord deformity with bowing of the cords on phonation. This causes the dysphonia and usually occurs without candidiasis. It was seen with beclomethasone dipropionate (in both pressurised aerosol and dry powder preparations), betamethasone valerate, and budesonide. It was related to the dose and potency of inhaled steroid and may represent a local steroid myopathy. It was reversed when the inhaled steroid was stopped, although resolution sometimes took weeks. Laryngeal candidiasis may have contributed to the vocal cord abnormality in two of these nine patients. Of the five patients without vocal cord deformity, laryngeal candidiasis was the sole cause of dysphonia in three. In the remaining two dysphonia was thought to be psychogenic. The vocal cord deformity may exist subclinically. Of nine patients who started to take aerosol steroid and who were examined monthly for one year, three developed vocal cord deformity but only one had persistent dysphonia. Vocal abuse did not appear to contribute to dysphonia.

Adult↗
PubMed1982

Effects of naftidrofuryl on breathlessness and exercise tolerance in chronic bronchitis.

Naftidrofuryl enhances oxidative phosphorylation and might therefore be expected to improve exercise tolerance and breathlessness in advanced chronic bronchitis. This hypothesis was tested in a four-week placebo-controlled trial in 11 bronchitic patients. Seven patients completed the study. There was no evidence of any benefit from naftidrofuryl either subjectively or after a 12-minute walking test.

Aged↗
PubMed1981

The bronchitic patient: a study of his employment problems.

Ninety-three male chronic bronchitics aged 40-64 years, 41 employed and 52 unemployed, were studied by structural interviews to evaluate factors leading to unemployment. Age was not important. Those employed were a little less disabled, and more were skilled, married, had working wives, had given up smoking, had tolerant employers and had suitable jobs, and fewer had travel problems. Of those unemployed most were not actively seeking work and, in half, income had not fallen with unemployment. Those interviewed felt that the Disablement Resettlement Officer, Industrial Rehabilitation Unit and their trade union did little to help with their problems. Ways to improve employment prospects for bronchitics are discussed.

Adult↗
PubMed1980

Reinfection tuberculosis: two cases in the family of a patient with drug-resistant disease.

A 42-year-old housewife died of drug-resistant pulmonary tuberculosis. Two sons had earlier completed a course of treatment for drug-sensitive disease. Six months after her death both sons developed sputum-positive tuberculosis with a drug resistance pattern identical to that of their mother during her last year of life, and including resistance to drugs which neither son had received. In both cases immunocompetence to tuberculin was shown so that reinfection arose purely as a result of heavy exposure.

Adolescent↗
PubMed1980

[Complete triploidy in a liveborn premature (author's transl)].

Authors describe the clinical, pathological and cytogenetic data of a polymalformed premature with a complete a triploidy 69,XXY). This rare condition (30 cases in the literature) may be suspected in a premature with broad posterior fontanella, eye and ear anomalies, syndactily between IV and III fingers/toes, intersexual status and mielomeningocele. Frequently the placenta presents a molar or micromolar degeneration.

Abnormalities, Multiple↗
PubMed1976

Hyposensitisation with house dust mite vaccine in bronchial asthma.

In a double-blind placebo-controlled trial of tyrosine-absorbed Dermatophagoides pteronyssinus vaccine no improvement was seen in 45 patients with asthma sensitive to house dust mite. In particular there was no significant improvement in symptom scores, spirometry, and skin and nasal challenge test results. Some patients in other studies have benefited from doses of vaccine much stronger than those now commercially available, but the incidence of side effects has also been high.

Adolescent↗
PubMed1975

Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma.

The cardiac and bronchial effects of AH 5158 and propranolol were compared in a double-blind, placebocontrolled intravenous study on 10 asthmatics. AH 5158, like propranolol, is a non-cardioselective beta-adrenoceptor-blocking drug, but unlike propranolol it also has an alpha-adrenoceptor-blocking action. Both drugs produced equivalent cardiac(beta1) blockade, but propranolol produced bronchoconstriction, whereas AH 5158 did not. Hence the alpha-blocking action of AH 5158 seems to prevent the bronchoconstrictor effects of propranolol in these patients.

Adolescent↗
PubMed1975

Comparison of the effects of acebutolol (Sectral) and practolol (Eraldin) on airways obstruction in asthmatics.

The effects of oral practolol (Eraldin, I.C.I. Ltd) (300 mg) and acebutolol (Sectral, May & Baker Ltd) (300 mg) were compared in a placebo-controlled, crossover study in ten asthmatics. 2. Pulse rate, forced expiratory volume in one second (FEV1) and specific airways conductance were measured before and after a bronchodilator and the same procedure was repeated after taking acebutolol, practolol or placebo. 3. A mean increase in resting airways obstruction and reduction in bronchodilator response were evident with both drugs. The differences were statistically significant only after acebutolol for the logarithm of specific conductance. Mean plasma levels of the two drugs were similar. The response to both drugs was similar in the same patient and unrelated to severity of asthma. Mean reduction in resting pulse rate was statisitcally greater after acebutolol compared with placebo but not after practolol compared with placebo. 4. In any individual the beta-adrenoceptor blocking response is unpredictable and any beta-adrenoceptor blocking drug must be used with extreme caution in asthmatics.

Acebutolol↗
PubMed1975

The effect of intramuscular salbutamol in asthmatics.

1 In a double-blind placebo controlled dose-response experiment in six asthmatic patients with reversible airways obstruction the effect of i.m. salbutamol (4 mug/kg, 8 mug/kg or 12 mug/kg) was assessed by improvement in spirometry and change in pulse rate. 2 Salbutamol (8 mug/kg) resulted in a mean increase in FEV1 of 1 litre and a mean increase in pulse rate of 7 beats/minute. 3 It was concluded that salbutamol (8 mug/kg) was the optimal dose.

Adult↗