Biomedical subjects
Publications and source records attributed to C Sillero.
The effects of diltiazem on pentagastrin-induced gastric secretion were studied in 11 normal volunteers. Diltiazem 60 mg thrice daily for 10 doses did not produce any clear-cut effect on the increase in gastric acidity induced by either standard or low doses of pentagastrin. Despite the role of calcium on gastric secretion, diltiazem does not show promise as an agent capable of reducing gastric acidity.
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A double-blind comparison of cimetidine and placebo has been carried-out in 60 patients with acute pancreatitis. No clear-cut benefit from cimetidine was observed, either in the whole group, or in alcohol or gallstone-associated pancreatitis.
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We investigated the prevalence of the various genotypes of hepatitis C virus (HCV) in 281 patients evaluated between March, 2000 and March, 2002 in the health area of Elche. Of these patients, 55 were coinfected with human immunodeficiency virus (HIV). The genotype was related to viral load and the co-existence of HIV infection. Likewise, the relationship between these parameters and the presence of the HCV core antigen was established. The results indicate that genotype 1b was the most prevalent (38.4%) followed by genotype 3a (23.1%). Patients coinfected with HIV presented fewer infections due to group 1 genotypes (p < 0.05).Patients with HIV presented a greater viral load in all the genotypes, with genotype 3 presenting a high viral load. Detection of the HCV core antigen showed a close correlation with viral load determinations. Although not yet sufficiently assessed, determination of the HCV core antigen constitutes a simple technique that could eventually contribute to improving the management of patients with chronic HCV hepatitis.
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