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Biomedical subjects

C Sicot

Publications and source records attributed to C Sicot.

At least 37 records · Page 2Linked to original sources
PubMed1988

Abnormal tissue oxygenation in patients with cirrhosis and liver failure.

Systemic haemodynamic and hepatic venous pressures, arterial and mixed venous gases and arterial lactate concentration were measured in 35 patients with histologically proven alcoholic cirrhosis who had been classified into three groups (A, B and C). Eight alcoholic patients without cirrhosis on liver biopsy were also studied. Compared with group A patients, group C patients had significantly higher hepatic venous pressure gradient, cardiac index, O2 transport and arterial lactate concentration and significantly lower systemic vascular resistance, arteriovenous O2 content difference and O2 uptake. In group B patients, corresponding values fell between those of groups A and C. Group A patients, unlike group C patients, were not significantly different from patients without cirrhosis with respect to cardiac index, systemic vascular resistance, O2 uptake and arterial lactate concentration. Our results suggest that in patients with cirrhosis, liver failure-associated hyperdynamic circulation may be accompanied by an abnormal tissue oxygenation.

Acid-Base Equilibrium↗
PubMed1985

[Evaluation of the short-term prognosis of cirrhotic patients admitted to intensive care, using 4 scoring systems].

A prospective evaluation of 4 scoring systems routinely used as prognostic indexes: 2 in hepatology units (Classification of Child-Turcotte, Classification of Pugh et al.) (specialized systems) and 2 in intensive care units (Acute Physiology Score, Simplified Acute Physiology Score) (non-specialized systems) was undertaken in 61 cirrhotic patients. Overall accuracy, defined as the percentage of survivors and non-survivors correctly classified, was not significantly different whatever the specialized system used (range: 59.0 p. 100 to 75.4 p. 100). Similarly, no difference was observed between the two non-specialized systems (overall accuracy of 81.9 p. 100 for the Acute Physiology Score and of 90.0 p. 100 for the Simplified Acute Physiology Score). However, the overall accuracy given by the Simplified Acute Physiology Score was significantly higher than that obtained with the specialized systems (p less than 0.05). Furthermore, this nonspecialized system was as easy to calculate and more reproducible than the specialized systems. These results suggest that the Simplified Acute Physiology Score may be substituted for the Child-Turcotte and Pugh classifications as a prognostic index in cirrhotic patients admitted to intensive care units.

Adult↗
PubMed1976

A controlled study of therapeutic portacaval shunt in alcoholic cirrhosis.

A controlled study of therapeutic end-to-side portacaval shunt was carried out from 1968 to 1971 in 89 patients with alcoholic cirrhosis. Recurrent gastrointestinal bleeding was less common and chronic hepatic encephalopathy was more common in patients with shunts than in patients without shunts. The survival-rate was lower, but not significantly, in patients with shunts. No overall benefit of the operation could be demonstrated in cirrhotic patients with the selection criteria and the type of surgical shunt used in this study.

Adult↗
PubMed1976

Portal hypertension and primary biliary cirrhosis.

Portal hypertension has been regarded as an uncommon and late complication of primary biliary cirrhosis (PBC). 24 patients with PBC were investigated for portal hypertension. Esophageal varices were present in 20, 50, and 90% of the patients 1, 3, and 9 years, respectively, after the onset of pruritus and/or jaundice. Portal hypertension was responsible for gastrointestinal bleedings in 11 patients; bleeding was the first clinical manifestation of PBC in two of them. Wedged hepatic venous pressure was increased in all the patients with portal hypertension whether regenerative nodules were present or absent. Portacaval shunt was performed in five patients and was well tolerated in three of them. It is concluded that (a) portal hypertension is common in PBC; (b) the intrahepatic block is of the so-called postsinusoidal type, even in patients without regenerative nodules; (c) gastro-intestinal bleeding due to portal hypertension occurs in about half of the patients and may be the first manifestation of PBC; (d) portacaval shunt seems to be indicated when gastro-intestinal bleeding occurs in earlier stage of the disease.

Adult↗