[A case of immunoblastic lymphadenopathy with repeated interstitial pneumonitis (author's transl)].
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Biomedical subjects
Publications and source records attributed to C Shimazaki.
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To elucidate the characteristics of eye-head coordination during lateral gaze, eye, head and gaze displacements to 10 degrees, 20 degrees, 30 degrees, 40 degrees, and 50 degrees target presentations were analysed quantitatively in 10 normal subjects. Head displacement was recorded without mechanical restraint by a newly devised apparatus containing two terrestrial magnetic sensors. Eye movements were recorded using d.c. electro-oculography through bitemproal leads. (1) As the target angle increased, the latency of eye movement increased while that of head movements decreased. (2) The rise times of eye and head movements increased almost linearly with the target angle. (3) The maximum velocity of eye movement averaged 292 degrees/sec at 10 degrees, increased to 398 degrees/sec at 20 degrees, and remained unchanged thereafter. The maximum velocity of head movement increased linearly with the target angle. (4) The head displacement at the end of eye saccade became relatively larger as the target angle increased, though the sum of eye and head displacements, i.e. gaze, agreed with the target angle. (5) At the final resting position, the percentage of target angle attained by head displacement decreased from 93% to 10 degrees to 62% at 50 degrees. However, gaze displacement was exactly the same as the target angle, with little dispersion for each angle of gaze shift, indicating that the head rotation detector is an accurate device for recording horizontal head movement under natural conditions.
We immunophenotyped 128 patients with B-cell non-Hodgkin's lymphoma (B-NHL) of various histological subtypes using two-color flow cytometry (FCM), and found that lymphoma cells obtained from 31 patients (24.2%) coexpressed at least one of the following T-cell associated antigens (T-Ag); CD2 (2.3%), CD5 (18.0%) or CD7 (6.3%). Moreover, 3 patients expressed two kinds of T-Ag (CD2/CD5, CD2/CD7 or CD5/CD7) as reported by other investigators. Though we could not find coexpression of CD3, CD4 or CD8 antigen in any patients analyzed in our study, such T-Ag(+) B-NHL have also been reported in the literature. As clinical features, extranodular involvement and higher International Prognostic Index (high and high intermediate) seemed more frequent in T-Ag(+) B-NHL than T-Ag(-) B-NHL in our study. Such prognostic significance of T-Ag expression is also reported by other investigators especially in CD5(+) diffuse large B-cell lymphoma. In addition, two-color FCM for detecting such aberrant T-Ag expression in B-NHL is useful for monitoring the minimal residual disease in the subgroup with T-Ag(+) B-NHL.