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Biomedical subjects

C Sheard

Publications and source records attributed to C Sheard.

32 records · Page 2Linked to original sources

Blood glucose and insulin levels in normal subjects following a meal with and without added sugar beet pulp.

The fibrous components of sugar beet pulp were investigated to determine whether they would reduce the post-prandial rise in blood glucose and plasma insulin levels when incorporated into a mixed meal. On two separate occasions six healthy volunteers were given either a control meal (providing 86 g carbohydrate) or an identical meal with the addition of 20 g sugar beet pulp (test meal). Blood glucose and plasma insulin levels were measured post-prandially for 3 hours. There was no significant difference between the mean blood glucose of plasma insulin curves at any time after the two meals. Since viscous types of dietary fibers are known to be effective in reducing post-prandial hyperglycaemia and insulinaemia, it would seem that either the physio-chemical nature of the fibre or the procedure employed to extract the sugar renders the particulate fibre inactive.

Adolescent↗

Neuroanatomical bases of electrodermal hypo-responding: a cluster analytic study.

Schizophrenics and other psychiatric patients have been found to have a high incidence of electrodermal hypo-responding. Different neural mechanisms may underlie hypo-responding in these groups. The present study utilized cluster analysis of magnetic resonance imaging (MRI) and electrodermal orienting data to examine the neuroanatomical correlates of electrodermal hypo-responding in 15 schizophrenics, 15 psychiatric controls (predominately affective disorders), and 15 normal controls. The number of electrodermal responses was recorded during a standard orienting paradigm. MRI scans were obtained, yielding area measures for the pre-frontal cortex and lateral ventricle-brain ratios (VBRs). The number of electrodermal orienting responses and the MRI measures were transformed into zeta-scores and entered into an agglomerative hierarchical cluster analysis, which yielded three clusters. A 3 x 3 Chi-square analysis revealed that the three clusters significantly differed according to diagnostic group. Analyses of variance (ANOVAs) revealed that the first two clusters had significantly fewer electrodermal orienting responses than the third cluster (predominately normals). Further, the first cluster (predominately schizophrenics) had significantly smaller frontal lobes than the other two clusters. Additionally, the three normals in the first cluster had relatively high levels of schizotypy. The second cluster (predominately affective disorders) had significantly larger VBRs than the other two clusters. Schizophrenics in the three clusters differed with respect to gender composition and positive symptoms. Thus, diminished pre-frontal area may underlie electrodermal hypo-responding in a subgroup of schizophrenics and schizotypals, while enlarged ventricles may underlie the same phenomenon in the affective disorders and another subgroup of schizophrenics.

Adult↗