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Biomedical subjects

C Scully

Publications and source records attributed to C Scully.

At least 613 records · Page 34Linked to original sources

Parotid salivary secretion in diabetic autonomic neuropathy.

Parotid salivary flow rates and amylase concentrations were measured in three groups of eight subjects each (normal control, non-neuropathic diabetic, and neuropathic diabetic). Flow rates were significantly reduced in neuropathic diabetic patients as compared with normal controls (p less than 0.001) and non-neuropathic diabetic patients (p less than 0.02). Amylase concentrations were similar. These data are consistent with parasympathetic denervation of the parotid gland in diabetic neuropathy and provide evidence for a widespread distribution of autonomic denervation in diabetes.

Adult↗

Waiting for operations.

Explore the source record for details and available documents.

Appointments and Schedules↗

Assessing the patient at risk for oral squamous cell carcinoma.

Patients and health care workers require continuing education to promote knowledge of the signs, symptoms, and risk factors for oral cancer. This paper reviews the literature assessing diagnostic tools that are currently available or being developed, in order to assist in the biopsy site selection and subsequent diagnosis of patients at risk for oral cancer. There is a general consensus that oral examination of patients at risk for oral squamous cell carcinoma (SCC) should be conducted on a routine basis. However, there can be false-positive and false-negative findings. Toluidine blue has been shown to be useful as an adjunct to the clinical examination when used by experienced clinicians. Exfoliative cytology is not currently used as a routine measure for the evaluation of lesions of the oral mucosa, but further development and the application of biologic markers to cytologic specimens may increase its value. Fluorescent imaging of malignant lesions of the oral mucosa has been shown to be sensitive and specific in animal models but thus far has been reported in only one human trial. The sensitivity and specificity of these techniques when used by general practitioners need to be assessed. Further, none of the above procedures has yet been shown to be a cost-effective public health measure in screening for oral cancer.

Biomarkers, Tumor↗

Orofacial disease: update for the dental clinical team: 11. Cervical lymphadenopathy.

By far the most common causes of lumps in the neck are swollen lymph nodes. The most common cause of cervical lymphadenopathy is infection in the area of drainage (virtually anywhere in the head and neck). Most frequent of all is an enlarged jugulodigastric (tonsillar) lymph node, inflamed secondary to a viral upper respiratory tract infection. Enlarged cervical lymph nodes may also be a manifestation of systemic infection (e.g. HIV/AIDS), or related to malignant disease in the drainage area (e.g. carcinoma) or elsewhere (e.g. leukaemia or lymphoma). These and less common causes are discussed in this, the last article in this series.

AIDS-Related Complex↗

Management of oral lichen planus.

Lichen planus is a relatively common disorder of the stratified squamous epithelia. Most dental and medical practitioners see patients with lichen planus, but not all are recognized as having the disease. Patients with lichen planus may have concomitant involvement of the disease in multiple sites. Oral lichen planus lesions usually have a distinctive clinical morphology and characteristic distribution, but oral lichen planus may also present a confusing array of patterns and forms, and other disorders may clinically mimic oral lichen planus. The etiopathogenesis of lichen planus appears to be complex, with interactions between genetic, environmental, and lifestyle factors. Much has now been clarified about the etiopathogenic mechanisms involved and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory in all cases and there is as yet no definitive treatment that results in long term remission, but there have been advances in the control of the condition. Amongst the many treatments available, high potency topical corticosteroids remain the most reliably effective, though topical cyclosporine, topical tacrolimus, or systemic corticosteroids may be indicated in patients whose condition is unresponsive to topical corticosteroids.

Humans↗

The NM23 gene and its expression in oral squamous cell carcinoma.

The murine nm23, a putative metastasis suppressor, has three human homologues, NM23-H1, -H2, and -H3b. Several reports have suggested a low metastatic potential for neoplasms with a high expression of NM23-H1 gene, while other studies have not shown this relationship. These apparent differences in the role of NM23 in metastasis suppression might be explained by unability to discriminate between the expression of the two genes NM23-H1 and NM23-H2. The NM23-H2 product is not related to tumor progression and metastasis suppression. Two studies on human oral squamous cell carcinoma (OSCC) have been reported, both showing the NM23 product to be a metastasis suppressor factor. However, none of these two studies distinguished NM23-H1 from NM23-H2. The aim of this study was to detect the protein expression pattern of NM23-H1 product in 24 OSCCs by immunohistochemistry in paraffin-embedded tissues using a monoclonal antibody non-cross-reactive with NM23-H2. The NM23-H1 positive group showed lower frequency of lymph node metastasis, and a better grading than the NM23-H1 negative group supporting the role of NM23-H1 as metastasis suppressor factor which may be useful for predicting tumor metastasis in OSCC.

Aged↗

Wound care. In on a limb.

In the light of nurses' increasing role in the assessment and diagnosis of leg ulcers, this article looks at leg ulcer management, focusing on increased aetiological factors, improved assessment techniques and treatment.

Bandages↗

Orofacial manifestations in the rheumatic diseases.

Rheumatic diseases will often affect the temporomandibular joint, but other orofacial tissues may also show manifestations. This article, based on a lecture given at the Royal National Hospital for Rheumatic Diseases, Bath, is intended to help the dental practitioner recognize and treat these symptoms.

Adult↗