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Biomedical subjects

C Scully

Publications and source records attributed to C Scully.

At least 577 records · Page 32Linked to original sources
PubMed1983

IgE and IgD concentrations in patients with recurrent aphthous stomatitis.

Serum IgE and IgD concentrations were examined in 80 patients with recurrent aphthous stomatitis (RAS), 20 patients with other ulcerative oral disorders, and 39 control subjects. both IgE and IgD concentrations were substantially greater in patients with RAS than in either the other patients with oral disorders or the control subjects. Although the increased IgE concentrations might be related to cell-mediated phenomena in the immunopathogenesis of RAS and the increased IgD concentrations might support the recently postulated role of IgD in immune responses related to the oral cavity, the possibility that the increased IgE and IgD levels are epiphenomena could not be excluded.

Adolescent↗
PubMed1982

Immunoglobulins G, M, A, D and E in Behcet's syndrome.

Serum IgG, IgM, IgA, IgD and IgE concentrations were examined in 26 patients with Behcet's syndrome, 70 patients with recurrent aphthous stomatitis and 56 healthy controls. IgA concentrations, but not IgG, IgM, IgD or IgE, were significantly raised in Behcet's syndrome compared with controls. Serum IgD and IgE concentrations but not IgA, IgG, or IgM were significantly greater in recurrent aphthous stomatitis than in controls.

Adolescent↗
PubMed1982

Immunological abnormalities in oral carcinoma and oral keratosis.

Examination of serum concentrations of IgG, IgA, IgM, IgE, and IgD in oral carcinoma and oral keratosis confirmed a rise in serum IgA concentration in oral carcinoma and revealed a rise in IgE. In oral carcinoma, other serum immunoglobulins were present in normal concentrations. Serum IgA and IgE were not increased in oral keratosis but IgM was reduced, with normal levels of other immunoglobulins. The results may reflect changes in cell-mediated immunity rather than simply changes in humoral immunity.

Carcinoma, Squamous Cell↗
PubMed1982

Crohn's disease of the mouth: an indicator of intestinal involvement.

Nineteen patients with clinical evidence of oral Crohn's disease but no intestinal symptoms were studied. Oral lesions in all patients were shown histologically to have lymphoedema with or without chronic granulomas consistent with Crohn's disease. Seven patients (37%) had demonstrable intestinal disease on rectal biopsy and four of these had abnormal bowel radiology. All seven had evidence of nutritional deficiency. Patients with clinical features suggesting oral Crohn's disease may have evidence of Crohn's disease in the intestine, although this may not be clinically apparent.

Adolescent↗
PubMed1982

Phagocytic and killing activity of human blood, gingival crevicular, and salivary polymorphonuclear leukocytes for oral streptococci.

The phagocytosis and killing of oral streptococci by blood, crevicular, and salivary polymorphonuclear leukocytes (PMNL) were examined using a visual assay based on differential staining of viable and non-viable microorganisms by acridine orange. Crevicular PMNL were 83% viable, 19% contained bacteria on collection, and phagocytosis occurred in vitro in 66% of glass-adherent leukocytes. Salivary PMNL were 56% viable, 11% contained bacteria on collection, and 44% phagocytosed streptococci in vitro. Crevicular and salivary PMNL were capable of phagocytosis and killing of oral streptococci, but both were impaired. Crevicular fluid was not significantly leukotoxic; mixed saliva caused a significant reduction in PMNL viability and in phagocytic and killing activity for oral streptococci. Crevicular PMNL may be actively functional phagocytes, but salivary PMNL are unlikely to be significant in oral defenses.

Animals↗
PubMed1982

beta 2 Microglobulin in lichen planus.

The aim of the present study was to examine idiopathic lichen planus for possible changes in the serum concentration of the immunological marker beta 2 microglobulin (beta 2m), a component of HLA antigens. It was shown that serum levels of beta 2m were not different in lichen planus from those in controls. Although these findings do not support major systemic immunopathological changes in lichen planus, they do not exclude the involvement of local immune mechanisms.

Beta-Globulins↗
PubMed1982

Circulating immune complexes detected by binding of radiolabelled protein A in patients with oral cancer and oral premalignant lesions.

Circulating immune complexes were determined in 48 patients with oral squamous cell cancer, 17 patients with oral keratosis and 49 controls, using a rapid sensitive assay using a Staphylococcus aureus immunoadsorbent. Concentrations of immune complexes were significantly higher in patients with oral cancer and in patients with oral keratosis than in controls, but the levels in those with oral cancer were not significantly different from those in keratosis. Immune complexes might be responsible for the cell-mediated immune defect in patients with cancer in the head and neck.

Antigen-Antibody Complex↗
PubMed1981

Serum alpha-amylase isozymes in mumps: estimation of salivary and pancreatic isozymes by isoelectric focusing.

Serum alpha-amylase isozymes were separated into three major isozymes by thin-layer gel isoelectric focusing and detected by a starch-iodine zymogram procedure. Of the three groups of isozymes, one (S isozyme) corresponded to a salivary specific form, one (P isozyme) to a pancreatic specific form and the third (SP isozyme) to isozymes of similar isoelectric point common to both secretions. The levels of total alpha-amylase and of these three isozymes were estimated in the sera of 54 patients with mumps. Total alpha-amylase and salivary isozyme concentrations were greatly increased in the sera of all patients compared with controls. Pancreatic isozyme concentrations however, were only slightly increased and did not correlate with clinical pancreatitis. Indeed, in patients with mumps associated with pancreatitis, meningoencephalitis or orchitis, levels of total serum amylase, although higher than controls, were lower than levels in patients who presented solely with mumps sialadenitis.

Adolescent↗