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Biomedical subjects

C Scully

Publications and source records attributed to C Scully.

At least 271 records · Page 15Linked to original sources
PubMed1994

Primary biliary cirrhosis. Sole presentation with rampant dental caries.

A 55-year-old woman was referred by her general dental practitioner for management of rampant dental caries of recent onset. Examination revealed a very dry mouth, angular stomatitis, and multiple carious lesions. Labial salivary gland biopsy showed features consistent with Sjögren's syndrome. Hematologic investigations showed antimitochondrial antibodies at a titer of 1 in 320, highly suggestive of primary biliary cirrhosis that was confirmed by liver biopsy.

Autoantibodies↗
PubMed1994

Epidermal growth factor and transforming growth factor alpha characteristics of human oral carcinoma cell lines.

This study examined the expression of epidermal growth factor (EGF) cell-surface receptors, the response to exogenous ligand and the autocrine production of transforming growth factor alpha (TGF-alpha) in normal and carcinoma-derived human oral keratinocytes. One of eight malignant cell lines overexpressed EGF receptors, while the remainder expressed receptor numbers similar to normal cells. Exogenous EGF stimulated incorporation of tritiated thymidine in a dose-dependent manner. In keratinocytes expressing normal numbers of EGF receptors, the cellular response to exogenous EGF correlated positively with total EGF receptor number. SCC-derived keratinocytes produced more TGF-alpha than normal cells. There was no statistical correlation between the autocrine production of TGF-alpha, EGF cell-surface receptor expression and cellular response to exogenous EGF. While the growth-stimulatory effects of exogenous TGF-alpha were inhibited by the addition of a neutralising antibody, the presence of this antibody in conditioned medium failed to produce a similar decrease in growth. The results indicate that overexpression of EGF receptors is not an invariable characteristic of human oral squamous carcinoma-derived cell lines. Further, the contribution of TGF-alpha to the growth of normal and carcinoma-derived human oral keratinocytes in vitro may be less significant than previously documented.

Adult↗
PubMed1994

Views of dental patients about the education and practice of dentists.

The opinions of 253 adult U.K. dental patients were sought as to the scope of dental education. Most appreciated this was a university education and that it exceeded 3 yr. Nearly one half believed that apprenticeship was involved and one quarter believed that postgraduate experience in hospital was mandatory. Few acknowledged the wide breadth of training and a majority would consult a physician rather than a dentist regarding problems such as oral ulceration.

Adolescent↗
PubMed1994

Paracoccidioidomycosis manifesting as oral lesions: clinical, cytological and serological investigation.

Paracoccidioidomycosis (South American blastomycosis) is a systemic mycosis which can be associated with oral lesions. This study on a group of 14 patients showed oral lesions mainly on the gingival or alveolar mucosa, with pulmonary involvement detectable on chest radiography in most. Microscopic detection of the fungus on a direct smear showed positive results in all 14 patients. Serological investigations including immunodiffusion, counterimmunoelectrophoresis and immunoblot were also positive in 100% of cases. The results suggest that direct smear together with serology may obviate the need for lesional biopsy for the diagnosis of oral paracoccidioidomycosis.

Adult↗
PubMed1994

S100 protein in oral biology and pathology.

The demonstration of S100 protein is used extensively for both research and diagnostic purposes in oral biology and pathology. This article reviews the structure and putative function of S100, technicalities of S100 immunohistochemistry, the cells of the oral and perioral tissues which express S100 and the possible significance of S100 expression in disease.

Animals↗
PubMed1994

Human oral mucosal melanocytes: a review.

Despite the complex role of melanocytes in skin physiology, the function of oral mucosal melanocytes has attracted little research interest and remains largely unclear. This article reviews what is known about oral mucosal melanocytes and identifies areas of research that may shed further light on their role in oral biology.

Histocytochemistry↗
PubMed1994

Candida and oral candidosis: a review.

Candida species are the most common fungal pathogens isolated from the oral cavity. Their oral existence both as a commensal and an opportunist pathogen has intrigued clinicians and scientists for many decades, and recent investigations have revealed many attributes of this fungus contributing to its pathogenicity. In addition, the advent of the human immunodeficiency virus infection and AIDS has resulted in a resurgence of oral Candida infections. Clinicians are witnessing not only classic forms of the diseases but also newer clinical variants such as erythematous candidosis, rarely described hithertofore. Therefore, this review is an attempt at detailing the current knowledge on Candida and oral candidoses together with the newer therapeutic regimes employed in treating these mycoses.

AIDS-Related Opportunistic Infections↗
PubMed1994

Protective wear and instrument sterilisation/disinfection in UK general dental practice.

The 18,000 United Kingdom general dental practitioners registered for National Health Service (NHS) practice were surveyed in July 1991 to assess their current use of protective gloves, eyewear and masks, and instrument sterilisation. Nearly 7,000 (6,588) valid responses were obtained immediately; of these, 70% of practitioners wore gloves routinely for clinical work, but only 14.5% donned new gloves for each patient. About 60% wore protective eyewear routinely or all the time but 12% never wore eye protection, and only 36% of practitioners used masks. Autoclaves or chemical solutions were the most popular methods to disinfect handpieces, but less than half the respondents stated that handpieces were sterilised or disinfected after each patient use. Most respondents (81%) routinely used autoclaves for sterilisation of other instruments. Although the response rate to the questionnaire was low, the results indicate that, despite the risks of, and publicity about, cross-infection, a substantial number of NHS dental practitioners may not adequately disinfect or sterilise their equipment between patients.

Attitude of Health Personnel↗
PubMed1994

Oral lichen planus and chronic active hepatitis B: a salutary tale.

Oral lichen planus is occasionally associated with chronic active hepatitis or primary biliary cirrhosis. This paper describes a patient who presented with oral lichen planus and proved to have chronic active hepatitis, evidently related to hepatitis B virus infection. Oral lichen planus appears occasionally to be associated with systemic infection with hepatitis B or hepatitis C viruses, particularly in patients from southern Europe.

Hepatitis B↗
PubMed1994

Oral mucosal disease: a decade of new entities, aetiologies and associations.

New patterns of oral mucosal disease and indeed new disorders have been emerging over the past decade. Although infection with human immunodeficiency viruses (HIV) is having the most profound impact, there are also major changes in oral health and the standard of health care required, because of other new disorders and medical care. The increase in tissue transplantation, with the concomitant use of immunosuppression is resulting in a range of oral problems. Other iatrogenic oral diseases likely to increase include ulcers associated with cytotoxic chemotherapy; lichenoid eruptions related to drugs and restorative materials; and a multiplicity of other complications. Dilemmas are presented by some new disorders such as orofacial granulomatosis. No less are the difficulties presented by the now obvious heterogeneous nature of oral subepithelial vesiculobullous disorders. Finally, there are, even in these days of social medicine and antimicrobial availability, new infectious diseases emerging. Continued increases in population mobility; continued sexual promiscuity; and the development of new drugs are all likely to act to increase the spectrum of oral disorders seen.

Humans↗
PubMed1993

Can HIV be transmitted from dental personnel to patients by dentistry?

Over 19,000 patients treated by 57 HIV-infected health care workers (HCWs) have been tested for HIV. Apart from the notorious Florida dental case, no patient has been shown to be infected by treatment given by an HIV-infected HCW. Cases of 10 HIV-infected HCWs have been examined in some depth. The evidence indicates that HIV transmission from HCWs to patient is exceedingly improbable, and almost impossible where recommended infection control procedures are adhered to.

Dental Care↗