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C Schulze

Publications and source records attributed to C Schulze.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Etiology of Cheilognathopalatoschisis (author's transl)].

Cheilognathopalatoschisis of the "common" type is a disturbance which goes beyond the actual region of the cleft and almost regularly involves the dental system as a whole, namely in the form of hypodontia. Whether the cleft and hypodontia anlage also affect the growth of both jaws in the sense of progenia is still not known. Equally, the question whether the pathogenetically different types of cheilognathopalatoschisis and isolated cleft palate can be separated etiologically from each other is not yet definitely clarified.

Anodontia↗
PubMed1981

Multinucleate Sertoli cells in aged human testis.

The present investigation documents morphological characteristics of human Sertoli cells of aged males. Testicular material was obtained from 35 patients (age 62-84 years) with carcinoma of the prostate who had received no previous anticancer therapy. As revealed by light and electron microscopy the appearance of the germinal epithelium showed great individual variations. In all cases examined, however, the occurrence of multinucleate Sertoli cells was a common finding. In seminiferous tubules with intact spermatogenesis these cells closely resembled the normally occurring variants, whereas they displayed features reminiscent of immaturity in the absence of germ cells. It is hypothesized that the nuclei of Sertoli cells in the special situation of aging may resume the capacity to divide, an ability normally restricted to immature cells. Thus, mitosis without subsequent cytokinesis might be an explanation for the formation of multinucleate Sertoli cells.

Aged↗
PubMed1979

Morphological characteristics of the spermatogonial stem cells in man.

The present investigation is concerned with establishing morphological criteria of spermatogonial stem cells in man. Testicular biopsies from patients having undergone semicastration for malignant tumors and radio- and chemotherapy for one year following the operation were studied light and electron microscopically. Those spermatogonial types that survived the treatment were regarded as stem cells in view of the fact that the stem cells, in contrast to the more differentiated spermatogonia, are radiation resistant and less sensitive to various noxious agents. In 7 out of 28 cases examined, a small number of spermatogonia was found adjacent to the basement membrane. The majority of these cells show the characteristic features of pale type A spermatogonia, while a few cells may represent variants of this cell type. The dark type A spermatogonia are almost completely eliminated from the seminiferous tubules. A concept is proposed that the stem cells of the human testis may be derived from the pale type A spermatogonia or the variants of this cell type.

Cell Nucleolus↗
PubMed1978

[Contribution to the formal pathogenesis of the classical seminoma. Early diagnosis from testicular biopsies?].

13 cases of seminoma of the testes were investigated in detail by means of light microscopy using paraffin and semithin sections. Paraffin sections were the basis for diagnosis, therapy, and prognosis. In semithin sectins, even individual seminoma cells within the seminiferous tubules were recognized by characteristic cytological features. In semithin sections also the development of the solid tumor from intratubular seminoma cells was elucidated. On the basis of our findings, the following concept of seminoma spread may be advanced: intratubular seminoma cells invade the lamina propria and gain access to to the interstitial tissue. Subsequent to the migration of seminoma cells, the tubules are smaller in diameter and contain only Sertoli cells. The seminoma cells in the interstitial tissue increase in number and build up the solid tumor.

Adult↗
PubMed1978

[Behavior of body weight during pregnancy].

Attitude of weight during 12. up to the 42. week of pregnancy was observed with 946 pregnant women which had an regular course of pregnancy. The normal range of the weekly grow of weight was given in an average for this period, and dissemination was found out. By this, compared with all the pregnants, a separation was made when representing women who brought forth compared with all the pregnants, a separation was made when representing women who bought forth the first time and such who had given birth to more children. Further on, the variety of weight attitude depending from parity, distribution of the age, and body tallness was taken into consideration. This substantially showed independence of the masium grow of weight from parity, age, and tallness of the pregnants between the 21. and 25. week of pregnancy. Altogether, those who give their first birth as well as younger and taller women show a stronger grow of weight during pregnancy than those who have already born more children, or older and smaller women.

Adolescent↗
PubMed1977

On the histology of human seminoma: development of the solid tumor from intratubular seminoma cells.

Intratubular seminomas of the testis associated with solid tumors were studied by light and electron microscopy in order to obtain information about the earliest stage of emigration from the tubules and invasion of the interstitial space. Careful examination of numerous sections reveals that at this stage neoplastic cells protrude into evaginations of the tubule covered by basement membrance or directly invade that membrane. At the site of tumor cell emigration, the basement membrane is thickened and multilayered. Tumor cells devoid of basement membrane were found in the interstitium. Their transmigration through the basement membrane was never observed. Subsequent to the migration of seminoma cells the tubules are smaller in diameter and contain only Sertoli cells. From the observations described it is inferred that tumor cells in the interstitial tissue increase in number, form strands and lobules, and finally build up the solid tumor.

Adult↗
PubMed1976

On the morphology of the human Sertoli cells under normal conditions and in patients with impaired fertility.

Sertoli cells in testicular biopsies from 7 patients with Sertoli-cell only syndrome, 8 patients who had been treated with cyclophosphamide for testicular neoplasia, 8 patients with oligozoospermia, 7 patients with cryptorchidism, and 8 patients with seminoma were examined under the electron microscope and compared with Sertoli cells of normal tissues. The investigations reveal that each of these conditions of impaired fertility is characterized of a special type of Sertoli cell. The cell pattern is either restricted to one or two of the normally occurring cell types, or modified cells predominate that might be typical of the underlying disturbances of spermatogenesis. It is suggested that the cell type which prevails in the Sertoli-cell only syndrome is capable of maintaining a basic production of a substance that inhibits FSH secretion.

Adult↗