[Magnetic resonance tomography of the orbit in endocrine orbitopathy].
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Adult↗
Biomedical subjects
C Schubert
Publications and source records attributed to C Schubert.
[Morphologic changes in the epithelium of myocutaneous pectoralis major islands flaps. A light and electron optic study].
On a long-term basis, the epithelium of pectoralis major flaps incorporated in the mouth and the oropharynx is macroscopically and microscopically very similar to the sourrounding mucosa. Light microscope and electro microscopic investigations show that the type of keratinization of the epithelium of this flap has changed from orthokeratosis to parakeratosis which is typical for the mucosa of the mouth. The possible reasons for these changes, which, to our knowledge, have not been described before, are discussed.
Biopsy↗
[Comparative clinical studies of myocardial blood flow in coronary heart disease with two nifedipine preparations].
Clinical, ergometric and scintigraphic examinations were performed before and after oral administration of a commercially available nifedipine preparation used as a standard (reference preparation; dosage: 3 x 10 mg/d) in 21 patients with angiographically verified coronary artery disease. In an open comparison study the same parameters were investigated after a 4 week course of a different nifedipine preparation as a test preparation (Corotrend; dosage: 3 x 10 mg/d). The study was performed in order to determine whether there were quantitative differences in myocardial microperfusion when different galenical preparations of nifedipine were used. There were no statistically significant differences between the two nifedipine preparations in the test parameters recorded. Both substances were associated with highly significant increases in microperfusion as compared to findings in the washout phase. Clinical effects on incidence of chest pain and on reductions in blood pressure were comparable. Patients demonstrated slightly better exercise tolerance with the reference agent, and computerised impulse-rate analysis of the tomoscintigrams demonstrated somewhat better microperfusion with this drug, though the differences between the two agents did not attain statistical significance. As the result of this analysis the two drugs would appear to be equivalent in clinical potency.
Aged↗
[Progressive lymphangiokeratoma and angiosarcoma (Stewart-Treves syndrome) in congenital lymphedema].
Three unusual clinical and histopathological changes were found in a 59-year-old male patient with congenital lymphedema of the lower left leg. Firstly, a keratotic lymphangioma had developed in the course of only a few years and in the end involved the entire left leg up to the buttocks--far beyond the edematous area. Secondly, concealed beneath the lymphangiokeratoma, a solitary tumor almost the size of a table-tennis ball was found on the outer side of the lower left leg. Histopathologically, the tumor proved to be a malignant angiosarcoma, which had grown over a period of some months. It was characterized histopathologically by solid and angiomatous differentiation. Thirdly, the superficial and deep lymph vessels revealed remarkable atypia and papillary proliferations of endothelial cells. After amputation of the left leg at the thigh, with complete removal of the angiosarcoma, but leaving the pathologically altered vessels in the upper part of the left leg and the buttocks, no clinical signs of metastases of progression have been noted during the first year after operation.
Amputation, Surgical↗
Interaction of adrenal and pancreatic hormones in the control of hepatic enzymes during development.
In the liver of suckling rats, the synthesis of hepatic tyrosine aminotransferase, serine dehydratase, and phosphofructokinase 2 as well as of renal beta-glucosidase is controlled by the circulating concentrations of adrenal and pancreatic hormones. Glucagon is capable of stimulating enzyme synthesis only in the presence of a steroid hormone. Dexamethasone and estradiol have been found to exert a permissive function on the inducibility of the studied enzymes by glucagon. Between the hormones of the adrenal medulla and glucagon antagonistic effects in enzyme induction were observed. Obviously, this antagonism is mediated by the alpha 1-adrenergic signal transferring system. A characteristic age dependence of enzyme induction by dexamethasone has been established. This might be correlated to alterations in the degree of methylation of the respective promoters. The methylation inhibitor 5-azacytidine influences significantly the enzyme induction by glucocorticoid hormones.
Adrenal Cortex Hormones↗
Does intravenous ritodrine therapy cause capillary endothelial damage?
The effects of intravenous (IV) ritodrine therapy on capillary endothelial damage and colloid osmotic pressure were examined in 15 patients in premature labor. Plasma fibronectin, a marker for capillary endothelial damage, did not change significantly after IV ritodrine therapy. Plasma colloid osmotic pressure was lowered following ritodrine therapy (P less than 0.05). Pretreatment plasma fibronectin levels in the study and control groups were similar. Interestingly, pretreatment colloid osmotic pressure in the study group was significantly lower than that of the control group (P less than 0.05). Our data suggest that there is no evidence of capillary endothelial damage following ritodrine therapy. Lower levels of plasma colloid osmotic pressure in patients with preterm labor, which are further reduced with IV ritodrine therapy, may predispose these patients to pulmonary edema.
Adult↗
Hormonal control of fructose 2,6-bisphosphate concentration and of phosphofructokinase 2 in the rat liver during development.
In fetal rat liver the concentration of fructose 2,6-bisphosphate is decreased by administration of glucagon. The glucagon effect, i.e., the phosphorylation state of phosphofructokinase 2, dominates over the substrate supply. Insulin was found to increase fructose 2,6-bisphosphate only when exogenous glucose is supplied simultaneously. The total activity of phosphofructokinase 2 exhibits remarkable developmental changes. It is high at term, moderate in the fetal as well as in the mature organ, and low during suckling. The level of the enzyme during development is controlled by pancreatic and adrenal hormones.
Adrenal Cortex Hormones↗
[Extramammary Paget's disease: clinical and histologic documentation of 2 forms].
There are two forms of extramammary Paget's disease in respect of clinic, therapy and prognosis. In most cases (about 95%) extramammary Paget's disease is an intraepidermal manifestation of a cutaneous adenocarcinoma. After horizontal spreading within the epidermis, malignant growth continues along the adjacent adnexal structures with dermal spreading and subsequent metastases. In rare cases (approx. 5%), extramammary Paget's disease is an epidermal manifestation of an adenocarcinoma primarily located in the intestinal or urogenital tract. Further diagnostic and therapeutical procedures depend upon the type of extramammary Paget's disease.
Adenocarcinoma, Mucinous↗
Mast cells and macrophages in early relapsing psoriasis.
Five patients with widespread plaque-type psoriasis were treated continuously with clobetasol under occlusion. Clinical healing was seen after 6-10 days of treatment. All plaques treated in this way clinically relapsed approximately 12 days later. During the period of remission, sequential biopsies were taken and prepared for light and electron microscopy. Histologically, the earliest indications of relapse were endothelial alterations (swelling, intercellular widening) followed by the appearance of mast cells around the postcapillary venules; these mast cells showed signs of degranulation. Hours later, activated macrophages showing pericellular edema were present, and these migrated into the epidermis soon after. Associated with the presence of macrophages, there was a complete loss of desmosome-tonofilament complexes. Later, lymphocytes and neutrophils were seen. Under these experimental conditions, the psoriatic-tissue alterations appear to have been initiated by degranulating mast cells as well as by macrophages which later invaded the epidermis.
Clobetasol↗
White sponge nevus of the vulva.
The white sponge nevus is a hereditary leukokerotosis localized preferably in the oral mucosa, but may simultaneously manifest itself in other regions, e.g. perianally. We report the case of a 18-year-old patient with a primarily and exclusively extraorally located white sponge nevus of the vulva. The differential diagnosis and clinical as well as therapeutical problems of this extremely rare disease are discussed.
Adolescent↗
[Extraoral manifestation of a white sponge nevus of the mucosa].
The nevus spongiosus albus mucosae (resp. white sponge nevus in the angloamerican literature) is a hereditary leukokeratosis localised preferably in the oral mucosa, but may simultaneously manifest itself in other regions, e.g. perianally. We report the case of a 18-year old patient with a primarily and exclusively extraorally located nevus spongiosus albus mucosae of the vulva. The differential diagnosis and clinical as well as therapeutical problems of this extremely rare disease are discussed.
Adolescent↗
[Effect of bran diet on organic acids in the gastrointestinal tract and apparent digestibility in weanling piglets].
Over a period of four weeks 88 piglets of an average weaning weight of 9.5 kg received rations with 2.1, 3.1 and 5.5% crude fibre in the original substance in the form of wheat bran. Between the 42nd and 49th day of life a digestibility investigation was carried out by means of Cr2O3, and on the 42nd and the 63rd day of life the organic acids in the complete gastro-intestinal tract could be ascertained, the causes of which are to be found in the lack of easily soluble carbohydrates (increased passage rate, bran quota). Due to crude fibre, the apparent digestibility of all nutrients decreased, which resulted in a lower live weight on the 63rd day of life. The effect of a bran diet in the alimentary prophylaxis of coli enterotoxaemia is thus furthermore substantiated.
Aging↗
Perinatal changes of fructose 2,6-bisphosphate in the rat liver.
In order to investigate a possible regulatory role of fructose 2,6-bisphosphate in early developmental stages, where profound changes in the carbohydrate metabolism are known to occur, this effector was estimated in fetal and postnatal rat liver. Polyphasic changes of the hepatic fructose 2,6-bisphosphate levels were found, which could be correlated to alterations in the glucose metabolism. A minimum in the hepatic fructose 2,6-bisphosphate level at the -3rd day coincides with the initiation of glycogen synthesis and its increase two hours after birth concurs with glycogen mobilization.
Aging↗
Oscillations in the phosphofructokinase-fructose 1,6-bisphosphatase cycle. I. Purification and kinetic characterization of fructose 1,6-bisphosphatase from pig liver.
A rapid and effective purification procedure for pig liver fructose 1,6-bisphosphatase in neutral form is described. The procedure involves heat treatment and chromatography with CM-Sephadex with specific elution of the enzyme by fructose 1,6-bisphosphate and AMP. The enzyme was found suitable for integration into a reconstituted enzyme system in which the generation of oscillations is investigated. The kinetic properties of fructose 1,6-bisphosphatase are studied under conditions compatible to those applied for the investigation of the dynamic behaviour of the reconstituted system (pH 6.6, presence of inorganic phosphate). The enzyme is significantly inhibited by AMP and fructose 6-phosphate. The substrate fructose 1,6-bis phosphate has a high affinity to the enzyme and was found weakly inhibiting even at high concentrations. The kinetic results are interpreted in terms of a mathematical model which reflects the interaction of the various effectors with the enzyme.
Animals↗
[pH value in the anterior tract of weanling piglets].
Caused by weaning, an increase of the pH-value in the stomach from under 3.5 to over 4.5 was ascertained; subsequently the values approached 4. In the fore of the jejunum higher pH-values occur, which, after the adaptation to the starter feed, significantly decrease to values around 6. The alimentary coli prophylaxis directed towards the decrease of the stomach-pH is emphasised because different stomach values have their effects in the jejunum as well.
Animals↗
[Salmonella in free living snakes of Northern Germany (author's transl)].
Fourty-nine adders (Vipera berus L.) and thirty-one grass-snakes (Nitrix natrix L.) from northern Germany were investigated by cloacal swabs. The samples were usually taken in the field and preenriched in peptone water and further-on processed in three steps of tetrathionate. After each step of enrichment the material was transfered to salmonella shigella agar and fuchsine lactose agar (acc. to Endo). Salmonella screening was done by inoculation of lactose positive and lactose negative colonies into lysine iron agar (acc. to Edwards and Fife). Salmonella excretion was found in 59% of the adders and in 68% of the grass-snakes. Some specimens excreted several Salmonella species. 22 different species resp. variants were detected, of which 19 species belonged to subgenus III (Arizona). Subgenus I occured infrequently and was represented by S. duesseldorf, S. heidelberg and S. sunnycove. Three new triphasic variants S. III 17:Z10: e, n, x, z15: z56, S. III 38: (k): z35:z56 and S. III 50:z10:z:z56 of species already known and four so far unknown species S. III (6), 14: 1,v:z (Ar. 7a, 7c:23-31), S. III 21:1,v:z57 (Ar. 22:23-40a,40c), S. III 43:1,v:z56 (Ar. 21:23-38) and S. III 28:z10:z57 (Ar. 35:27-40a,40c) were discovered. The present results suggest that adders and grass-snakes in northern Germany represent autonomous reservoirs of salmonellae. There exist only few relations between the Salmonella species in these kinds of snakes and other European snakes.
Animals↗
[Four new Salmonella species and three serological variants of subgenus III (Arizona) (author's transl)].
Four new strains of Salmonella and three serological variants described in this paper were isolated from free living snakes (Vipera berus L. and Natrix natrix L.) of Northern Germany. All strains belong to the subgenus III of the genus Salmonella. For the first time a representative of subgenus III in the Salmonella group M with the serological formula S. arizonae 28:Z10:Z57 was isolated. 1) S. (6),14:1,v:z (Ar. 7 a,7c:23-31) 2) S. 17:Z10:e,n,X,Z15:Z56 (Ar. 12:27-28-38) 3) S. 21:1,v:Z57 (Ar. 22:23-40a,40c) 4) S. 28:Z10:Z57 (Ar. 35:27-40a,40c) 5) S. 38:(k):Z35:Z56 (Ar. 16:22-21-38) 6) S. 43:1,v:Z56 (Ar. 21:23-38) 7) S. 50:Z10:Z:Z56 (Ar. 9a,9c:27-31-38)
Animals↗
Histological, immuno- and enzyme-histochemical investigations on the adenohypophysis of the urodeles, Mertensiella caucasica and Triturus cristatus and the caecilian, Chthonerpeton indistinctum.
The pituitary glands of two urodelan species (Mertensiella caucasica, Triturus cristatus) and one one caecilian species (Chthonerpeton indistinctum) were examined with histological (Alcian blue, Brookes' trichrome stain), enzyme histochemical (acid phosphatase, alpha-naphthylacetate-esterase, acetylcholinesterase) and immunofluorescence techniques (anti-carp GTH, anti-ovine prolactin, anti-synthetic alpha-MSH). In the pituitary gland of Mertensiella and Triturus six chromophilic cell types could be distinguished. A strong fluorescence was observed in the MSH-, GTH- and TSH-cells. In the pituitary gland of Chthonerpeton only five chromophilic cell types could be distinguished: in the rostral part of the pituitary gland the B3-cell; in the basal region of the central area the B2-cell; dorsocaudally the B1-cell. The acidophilic cells were found in the central and caudal part of the pars distalis. The basophils of the pars intermedia could be observed in the dorsocaudal part of the pituitary gland surrounding the neurohypophysis. All acidophilic cells showed a strong immunofluorescence with anti-ovine prolactin (LTH).
Acetylcholinesterase↗