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Biomedical subjects

C Schmoeckel

Publications and source records attributed to C Schmoeckel.

At least 109 records · Page 6Linked to original sources
PubMed1978

Monocytic leukemia. Clinically appearing as 'malignant reticulosis of the skin'.

Enzyme cytochemical (hydrolytic enzymes for cell differentiation), immunocytologic (B and T lymphocyte differentiation), and electron microscopic studies of skin infiltrates facilitate the proper diagnosis of myelomonocytic and lymphoreticular proliferations. With use of these methods, the original clinical diagnosis of malignant reticulosis of the skin was corrected to monocytic leukemia in a 65-year-old woman. Because primary involvement of the skin preceded monocytosis of the blood, it was concluded that the cutaneous infiltrates in our patient resulted from proliferation of tumor cells in the skin rather than from homing of the cells to, or settling of the cells in, the skin.

Aged↗
PubMed1978

Patterns of cutaneous lymphomas. Histological, enzyme cytochemical, and immunological typing of lymphoreticular proliferations in the skin.

During recent years there has been much progress in interpreting the histo- and cytomorphology of lymphoreticular proliferations by means of enzyme cytochemical (cell typing by hydrolytic enzymes) and immunological (B- and T-cell differentiation using surface markers and functional tests) methods. Applying these methods in skin biopsies from 101 patients clinically suspected of having cutaneous lymphomas, patterns of lymphoreticular infiltrations in the skin have been elaborated. Based primarily on the 'Kiel' classification, low-grade and high-grade malignant lymphomas, pseudolymphomas and 'histiocytic lymphomas' can be differentiated in the skin; however, there still remain some hitherto unclassifiable lymphoreticular proliferations. In the low-grade malignant lymphomas of the skin, mycosis fungoides, Sézary's syndrome and Pagetoid reticulosis histologically display a pattern which is typical for T-cell infiltrations in the skin, whereas most of the 'malignant reticuloses', including immunocytoma, show a B-cell pattern. Erythrocyte antibody complement rosette fixation on cryostat sections is positive only in cutaneous pseudolymphomas whereas no fixation is seen in malignant B-cell lymphomas of the skin.

B-Lymphocytes↗
PubMed1978

[Immunoelectron microscopy in dermatology].

The principle of immunoelectronmicroscopic studies using horseradish perpoxidase is described. This method, especially the peroxidase-antiperoxidase multistep technique, reveals more details about the exact localization of immunophenomena in different dermatological diseases. The results of immunological investigations performed on the ultra-structural level in bullous diseases, lupus erythermatosus, vasculitis, and psoriasis are summarized and compared with the immunofluorescent and classical electromicroscopic findings.

Dermatitis Herpetiformis↗
PubMed1978

[Secondary syphills appearing as reticulosis].

A case of secondary syphilis clinically appearing as malignant reticulosis was studied. The histology was characterized by many plasma cells and practically no mitoses. On the ultrastructural level many plasma cells, lymphocytes and macrophages were found, but no morphological signs of a malignant reticulosis such as Sézary or other atypical cells were apparent.

Diagnosis, Differential↗
PubMed1978

Prognostic index in malignant melanoma.

A retrospective study was undertaken of 146 surgically treated subjects with primary cutaneous melanoma of which 73 were disease-free for five to nine years and 73 developed later metastases. A prognostic factor was south to determine patients with poor prognoses. The best overall method was shown to be the evaluation of the prognostic index defined as the product of tumor thickness and the number of mitoses per square millimeter. However, for establishing a group of patients with no incidence of metastases, the mitotic rate proved to be as good a factor as the prognostic index and better than tumor thickness or levels of invasion. The application of this prognostic index seems therefore to be useful in selecting for further treatment stage I melanoma patients with poor prognoses, eg, prophylatic lymph node dissection and immunochemotherapy.

False Negative Reactions↗
PubMed1978

The cytolytic effect of PUVA treatment on PHA-stimulated human peripheral lymphocytes.

The morphology of PUVA-treated and PHA-stimulated human peripheral lymphocytes in vitro was studied by means of the light and electron microscopes. Most cells showed signs of cytolysis, such as pyknotic nuclei and a swollen and decomposed cytoplasm; a few cells, however, appeared as normal lymphoblasts. In the latter, repair-enzyme mechanisms may successfully have rectified alterations in the DNS prior to the inception of S-phase. These findings are discussed with reference to the in vivo effect of PUVA treatment.

Cell Nucleus↗
PubMed1977

Immunoelectronmicroscopical demonstration of in vivo bound complement C3 in psoriatic lesions.

The presence of in vivo bound complement (C3) within the stratum corneum of 4 psoriatic cases is demonstrated ultrastructurally by the use of the peroxidase-antiperoxidase multistep technique. The positive reaction product was located in the intercellular space and on the surface of the parakeratotic cells within the horny layer. The membranes of the horny cells were not altered and peroxidase granules could also not be detected within their cytoplasm. The explanation of this finding as well as its pathogenetic significance is discussed.

Animals↗
PubMed1977

The ultrastructure of lymphadenosis benigna cutis (pseudolymphoma cutis).

In an ultrastructural study supplementing previous histological, cytochemical and immunocytological investigations of lymphadenosis benigna cutis, the tumor is shown to consist mainly of two cell types: Lymphocytes and macrophagocytic (reticulum?) cells. The tendency to spontaneous regression is manifested on the ultrastructural level by pronounced degenerative alterations.

Diagnosis, Differential↗
PubMed1977

The dermal inflammatory reaction in initial psoriatic lesions.

The cellular infiltrate in the dermis of incipient psoriatic lesions was qualitatively and quantitatively evaluated using cytochemical methods for the differentiation of inflammatory cells. The greatest intensity of the dermal infiltrate was always in the center of early lesions. It was shown that most of the inflammatory cells within the perivascular areas of the upper dermis were macrophages, monocytes and lymphocytes. The number of mast cells was not increased; eosinophils and plasma cells could not be detected. Only seldom could a single or a few polymorphonuclear leucocytes be seen in lesions at a more advanced stage. These findings are discussed in the light of known immunological and functional mechanisms.

Dermatitis↗
PubMed1977

The ultrastructure of mycosis fungoides, of Sezary's syndrome, and of Woringer-Kolopp's disease (pagetoid reticulosis).

Skin lesions of 13 cases of mycosis fungoides, 2 cases of Sézary's syndrome and one case of Woringer-Kolopp's disease were studied. In mycosis fungoides two main cell types were observed: small atypical lymphoid cells, and large atypical lymphoid cells. The small atypical lymphoid cells were characterized by dense nuclei with varying degrees of nuclear lobulation. Normal-appearing lymphocytes and typical mycosis cells were in this cell group. The large atypical lymphoid cells were characterized by large nuclei with little lobulation and by less chromatin condensation, as well as by a more abundant cytoplasm. Their identification is discussed and indications of their possibly being neoplastic or proliferating lymphoblasts are given. In Sézary's syndrome Sézary cells with more lobulated nuclei than in mycosis cells and lymphoblast-like cells as in mycosis fungoides could be found. In Woringer-Kolopp's disease cells similar to Sézary cells aggregated mainly in the epidermis. No interdigitating reticulum cells and no other morphological signs of a specific lymphocyte microenvironment were found in any of the cases.

Dermatitis, Exfoliative↗
PubMed1976

[The histogenesis of Kaposi sarcoma: a histochemical and electronmicroscopical study (author's transl)].

UNLABELLED: 1. Histologically, Morbus Kaposi is primarily characterized by a proliferation of streams composed of spindle-shaped cells, by vascular slits lined by cells, and by a minor cellular inflammatory reaction. 2. The cells lining the vascular slits resemble endothelial cells and exhibit strong alkaline phosphatase activity and a clear leucinaminopeptidase activity. They contain Weibel-Palade bodies. 3. The ultrastructural analysis of the tumor cells shows a proliferative formation resembling capillary sprouts with and without lumina. The lumina are composed primarily of poorly differentiated endothelial cells. A second typical cellular component are fibroblast-like tumor cells possibly derived from perithelial cells. 4. Indicative of M.K. are also extravasation and phagocytosis of erythrocytes with intracytoplasmic decomposition, and storage of myelinlike structures somewhat resembling Schwannian-cells. 5. CONCLUSION: M.K. is characterized by a multifocal neoplasia of capillary like structures and by a progressive sarcomatous development.

Aged↗
PubMed1976

[Diagnosis and therapy of bromoderma tuberosum].

After taking bromine-containing drugs two patients developed bromoderma on the leg. This diagnosis was confirmed by high bromine-levels in the blood. Topical occlusive treatment with glucocorticosteroids was successfull.

Administration, Topical↗
PubMed1976

[Atypical Kaposi's disease].

To demonstrate that Kaposi's sarcoma may initially take several different courses, a case is presented and the literature reviewed.

Humans↗
PubMedDate not supplied

The acrosomal membrane system of boar spermatozoa--morphological and biochemical studies.

The distribution of the cell surface saccharides with alpha-glycosidically linked mannose and terminal galactose was displayed by fluorescence microscopical examinations with FITC-conjugated concanavalin A and Ricinus communis agglutinin-120. The lectin binding sites of the inner cellular membranes--inner and outer acrosomal membrane--were ultrastructurally localized by electron microscopical studies using the lectin-peroxidase technique. It could be demonstrated that both acrosomal membranes contain covalently bound carbohydrates. In order to characterize the acrosomal membrane components which are responsible for the binding to lectins, the outer acrosomal membrane was separated after homogenization by centrifugation through modified colloidal silica. The exposed membrane proteins were labelled by galactose oxidase mediated introduction of tritium into the carbohydrate side chains of the glycoproteins. After solubilization the membrane components were analysed by affinity chromatography and electrophoresis. For a general characterization the cholesterol/phospholipid ratio of ejaculated boar spermatozoa and the isolated membrane fraction was determined and some enzymatic activities were assessed.

Acrosome↗