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Biomedical subjects

C Schmoeckel

Publications and source records attributed to C Schmoeckel.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Dermatitis herpetiformis Duhring with linear deposits of IgA (linear IgA dermatosis)].

Three patients with linear deposits of IgA along the epidermal basement membrane were studied. The clinical and histopathological picture as well as the response to dapsone were typical of dermatitis herpetiformis. Two of the three patients were HLA-B8/DR3-positive. By immunoelectron microscopy, the previously reported two types of linear IgA deposits were confirmed: in one patient, the IgA precipitates were localized below the basal lamina as in dermatitis herpetiformis, in the other two above the basal lamina in the lamina lucida as in bullous pemphigoid. The immunoelectron microscopic findings imply that in some patients with linear IgA dermatosis a pathomechanism different from that in classical dermatitis herpetiformis may be operative.

Adult↗
PubMed1984

[Spinocellular cancer at the site of chronic discoid lupus erythematosus].

A case of squamous cell carcinoma is presented that developed within a tense, fibrotic scar caused by chronic discoid lupus erythematosus. The carcinoma appeared in a woman of 60 years of age who has had chronic discoid lupus erythematosus on the scalp for 30 years. According to the literature, the frequency of this type of malignant transformation is estimated to be within the same range as the incidence of squamous cell carcinomas arising within tense, fibrotic scars, that is ranging between 0.1% and 2.6%. Therefore, no additional carcinoma-promoting factors of different origin specific for chronic discoid lupus erythematosus could be found.

Alopecia↗
PubMed1984

How consistent are dermatopathologists in reading early malignant melanomas and lesions "precursor" to them? An international survey.

Nine cases thought to be "precursors" of malignant melanoma were submitted to 15 histopathologists who have a special interest in melanocytic lesions. The survey revealed that reliable, objective, and repeatable differentiation among benign melanocytic hyperplasias, "precursors," low-risk malignant melanomas, and Spitz's nevi was not achieved. Furthermore, the terminology varied considerably, and some of the same terms were not always used to mean the same things. Clinicians should be aware of the limitations of histopathological interpretations of lesions containing atypical melanocytes. A higher degree of unanimity appears possible when a more simplified and more widely accepted terminology is employed and when differentiating criteria are more clearly established.

Adult↗
PubMed1983

Pityriasis rubra pilaris: a clinico-pathological and therapeutic study with special reference to histochemistry, autoradiography, and electron microscopy.

Five patients with pityriasis rubra pilaris (PRP) were analyzed by means of light and electron microscopy as well as by histochemistry and autoradiography. The results were compared with findings in psoriasis vulgaris. In PRP we found a moderate increase of the labeling index of epidermal cells, a highly increased labeling index of dermal infiltrating cells, and a mild spongiosis, and in the stratum granulosum, a decreased number of tonofilaments and an increased number of keratinosomes. The horny layer in PRP showed a pronounced histochemical and electron microscopical parakeratosis, even when histological parakeratosis was absent. In contrast with psoriasis vulgaris, there was no exocytosis of polymorphonuclear leucocytes into the epidermis, the papillomatosis index was normal, and there were no tortuous capillaries in the dermal papillae. The stratum granulosum was always present and sometimes thickened, showing electron microscopical changes different from those referred to in psoriasis. These changes point to a relatively distinct pattern of epidermal changes in PRP.

Adult↗
PubMed1983

Low- and high-risk malignant melanoma--I. Evaluation of clinical and histological prognosticators in 585 cases.

In 585 cases with primary cutaneous stage I malignant melanoma (294 disease-free for at least 5 yr, 291 with later metastases) prognostic parameters were examined. The most effective proved to be tumor thickness and mitotic activity, particularly when combined as a prognostic index. Furthermore, vascular invasion, ulceration in thick tumors (thickness greater than or equal to 3.0 mm), severe cellular atypia, the small, lymphocytic-like cell type and the absence of an inflammatory reaction were closely associated with a high rate of metastatic cases. Less relevant prognostic factors were the level of invasion, sex, site, tumor breadth, clinical diameters and infiltrative growth. Tumor type, age, duration and an adjacent nevocellular nevus were not significantly associated with the occurrence of later metastases. Furthermore, the growth-type (exo- or endophytic) did not have a bearing on the prognosis.

Adolescent↗
PubMed1983

Low- and high-risk malignant melanoma--III. Prognostic significance of the resection margin.

The influence of the resection margin on the prognosis of malignant melanoma was investigated in 577 cases (stage I), 285 with later recurrences and 292 disease-free for at least 5 yr. The resection margins varied considerably, with less than or equal to 10 mm in 172 cases and ca. 50 mm in 85 cases. Low- and high-risk melanomas (determined by means of tumor thickness and mitotic index) were found to be distributed evenly, with only minor variations for different resection margins. The occurrence of metastases was found to be independent of the resection margin, and several statistical methods were used (correlation coefficients, chi-square tests, discriminant analyses). This was also true when high-risk cases were analyzed separately. In contrast, for low-risk melanoma (68 cases), the six metastatic cases had a resection margin less than or equal to 20 mm (11.8% vs 0%, P = 0.3). Furthermore, local recurrences (40 in 482 cases) were seen more frequently in cases with a resection margin less than 30 mm (10.0 vs 2.9%, P = 0.02). However, local recurrences did not appear to be responsible for disseminated disease, as 82.1% were at high and 10.3% were at medium risk. The benefit of a 5-cm resection margin could not be substantiated in this study. A 3-cm resection margin may be necessary to lower the risk of local recurrences and a 2-cm margin appeared to be sufficient for low-risk melanoma.

Adolescent↗
PubMed1983

Circulating Sézary cells in the diagnosis of Sézary syndrome (quantitative and morphometric analyses).

Plastic-embedded circulating Sézary cells were examined in semithin and thin sections (assisted by the nuclear contour index-NCI). Eight cases of Sézary syndrome were analyzed as well as 11 controls (3 cases of widespread eczemas and 8 cases of erythroderma), 7 cases of mycosis fungoides, and 3 healthy individuals. Discriminating criteria between Sézary syndrome and benign diseases were sought: in addition to Sézary cells (NCI greater than 6.5) intermediate lymphocytes (5.0 less than NCI less than or equal to 6.5) proved to be helpful. Cases with Sézary syndrome were clearly differentiated when the following 3 ultrastructural criteria were fulfilled: (1) Sézary cells (SC) greater than 9%; (2) intermediate lymphocytes (IL) greater than 20%; (3) the sum of SC and IL greater than 37%. A good correlation between thin and semithin sections was obtained (correlation coefficient for Sézary cells r = 0.82). Usually the values of SC were slightly higher on thin sections. The diagnosis of SS can be made on semithin sections when the ultrastructural criteria are fulfilled. In this way 8 of 12 samples of Sézary syndrome were correctly classified. Therefore, semithin sections (studied by light microscopy) are recommended as a routine method in the diagnosis of cases suspected of Sézary syndrome, whereas thin sections (studied by electron microscopy) appeared to be necessary in problem cases only.

Adult↗
PubMed1983

Treatment of cutaneous T-cell lymphomas with TP-5. Evaluation of the clinical effect in 8 patients.

Eight patients with cutaneous T-cell lymphomas (6 patients with mycosis fungoides, 1 patient with Sézary's syndrome, 1 patient with low-grade malignant lymphoma, unclassified) were treated with TP-5, a synthetic pentapeptide having the same biologic activity as the thymic hormone thymopoietin. TP-5 was administered three times weekly at a dosage of 50 mg subcutaneously in 6 patients, 50 mg intravenously in 1 patient, and 100 mg subcutaneously in 1 patient. Clinical evaluation at the end of the trial disclosed improvement in 4 patients (2 patients with mycosis fungoides, 1 patient with Sézary's syndrome, 1 patient with low-grade malignant lymphoma, unclassified), deterioration in 3 patients with mycosis fungoides and no change in 1 patient with mycosis fungoides. As TP-5 evidently exerts some effect on cutaneous T-cell lymphomas, further investigations of its therapeutic potential in this group of diseases seem worthwhile.

Adult↗
PubMed1983

[Lymphomatoid papulosis. Review and personal observation of 4 patients].

121 patients with lymphomatoid papulosis from the literature are reviewed with respect to clinical and histological features, laboratory findings, therapy and course of the disease. In addition, clinical, histological, enzymecytochemical and immunological findings in four own patients with lymphomatoid papulosis are reported. Males are more often affected than females. The typical clinical features are papules measuring 1-2 cm in diameter, most frequently located at the extremities. The course of the disease is rhythmic prolonged over many years. Transition into malignant lymphoma occurs. The presence of blasts and epidermotropism of the infiltrate are obligatory histological criteria. Mitoses are present in about two thirds of the patients. Signs of vasculitis, eosinophilic and neutrophilic granulocytes are found in less than half of the patients. Based on enzyme cytochemical and immunocytological findings in conjunction with the course of the disease lymphomatoid papulosis is designated as pseudolymphoma of T-cell type.

Adolescent↗
PubMed1983

[Acneiform exanthema caused by azathioprine].

An acneiform eruption due to azathioprine was demonstrated through patch-tests and through elicitation on challenge. The intrafollicular sterile inflammation with abscess formation and the direct manifestation without a sensitization period are not consistent with a normal allergic mechanism.

Acne Vulgaris↗
PubMed1983

[Alkaptonuria (ochronosis)].

A 39-year-old male patient observed an increasing bluish pigmentation of the ear cartilage associated with recurrent back-pain. Darkening of the urine after the addition of sodium hydroxide led to the suspected diagnosis of alkaptonuria. This diagnosis was confirmed by the detection of urinary homogentisic acid by thin-layer chromatography.

Adult↗