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Biomedical subjects

C Schlesinger

Publications and source records attributed to C Schlesinger.

23 records · Page 2Linked to original sources
PubMed1984

Comparative quantitative aspects of putative neurotransmitters in the central nervous system of spiders (Arachnida: Araneida).

The amounts of eight putative neurotransmitters or modulators (acetylcholine, dopamine, noradrenaline, adrenaline, GABA, taurine, glutamic acid, glycine) were determined from the CNS of 12 species of five different spider families (Theraphosidae, Agelenidae, Araneidae, Lycosidae, Salticidae). Comparatively high contents of acetylcholine and noradrenaline could be found in the CNS of hunting spiders, higher contents of GABA and taurine were visible in the web-building spider families, while extraordinarily high amounts of glutamic acid were confined to the Theraphosidae. The results obtained are compared with findings from other arthropod groups and the role of putative transmitters or modulators in the spider CNS is discussed in relation to behavioural differences within the families investigated.

Acetylcholine↗
PubMed1984

Treatment of advanced breast cancer with two doxorubicin-containing regimens.

The Georgetown University Hospital experience in the treatment of advanced breast cancer using either a combination of doxorubicin (adriamycin) and vincristine (AV) or adriamycin and mitomycin-C (AM) is presented. Of 74 previously treated patients with advanced breast cancer, 50 patients were given AV and 24 patients were given AM. Both groups were comparable in regard to number of disease sites, age, prior radiation therapy, disease-free interval after mastectomy, duration of treatment, and estrogen-receptor status. The response rates were 32% and 25% with AV and AM combinations, respectively. Achievement of response was not related to menopausal or estrogen-receptor status. Median time to disease progression was 7.0 and 9.6 months for AV and AM, respectively. Median survivals were not statistically different (9.7 months for AV and 11.1 months for AM). Life-table analysis for responders versus nonresponders within each regimen and between responders in either regimen revealed no statistical differences. Duration of response for each regimen was also equivalent. Toxicity was mild and similar to previous reports using these drugs. However, myelosuppression was significantly greater for premenopausal than postmenopausal patients in the AV group. The possible reasons for this are discussed. Both AM and AV are well-tolerated regimens which provide equivalent but limited response rates, duration of response, and median survival in previously treated women with advanced breast cancer.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1981

[Ontogenesis of the acetylcholine system in the brain of the South African clawed toad (Xenopus laevis Daudin)].

1. During the development of the acetylcholine system of the Xenopus brain a distinct increase in neurotransmitter content was found which is interpreted as an expression of increased activity of cholinergic neurons. The acetylcholine content in the whole brain increases markedly from hatching to metamorphosis. During this period regional differences of transmitter distribution can be observed. 2. The ChAT activity of the whole brain remains constant during total larval life, whereas the AChE activity increases with the beginning of metamorphosis. Comparing the different brain parts, both enzymes show a regional decrease in activity from caudal to rostral, whereas in adult animals the enzyme activity of the midbrain is dominant.

Acetylcholine↗