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Biomedical subjects

C Schlegel

Publications and source records attributed to C Schlegel.

32 records · Page 2Linked to original sources
PubMed1980

[Experience from amniofoetography in second half of pregnancy (author's transl)].

Fourteen amniofoetographies were evaluated in tabulated form, with methods and results being reported in this paper. Indications were limited. The importance of amniofoetography to differential diagnosis was found to be based on the specificity of ultrasonographic findings as well as on the disclosure of atresia in the gastro-intestinal tract and of congenital hydrops in cases of hydramnion.

Abnormalities, Multiple↗
PubMed1979

[Clinical value of various parameters in antenatal diagnosis of fetal hypotrophia (intrauterine retardation) (author's transl)].

Retrospective evaluation of percental frequency of pathological data gained by prepartual monitoring in pregnancies at risk of 180 small for gestational age infants and 130 eutrophic ones at term (postnatal classification). Parameters of interest were continuous maternal gain of weight, monthly progress of the size of the uterus, continuous ultrasomic cephalometria, maternal urinary estriol and serum heat stable alkaline phosphatase as well as amnioscopia and cardiotokographia with and without oxytocin challenge test. -- It seems that there is a significant better prediction of fetal retardation with the help of common clinical methods as well as with ultrasonic and that they are superior to the examined biochemical, cardiotocographical and amnioscopical parameters. With regard to possible additional disturbances of the fetoplacental unit--especially of respiratory placental function--in suspected intrauterine retardation the complete monitoring program should be taken.

Alkaline Phosphatase↗
PubMed1979

[Mode of delivery, postnatal condition and neonatal outcome in preterm infants].

There were under examination 578 preterm infants of two groups--28. up to 31. and 32. up to 36. week of gestation--after birth of vertex as well as breech prevention. Postnatal condition and neonatal outcome were put into relation to the mode of delivery. We compared Apgar-Score (one and five minute value), morbidity on respiratory distress syndrom as well as rate of survival and neonatal mortality in spontaneous delivery with and without episiotomia, with specula delivery, Shute-forceps and vacuum extraction of vertex presentation as well as with breech presentation after vaginal delivery and primary Caesarean section. In respect of the management of the second stage of labour it is our opinion that prophylactic additional measures in preterm delivery of vertex presentation after 32 weeks of gestation are not necessary and that this question should be examined in a larger study of much more cases. But we were able to demonstrate that up to 32. week of gestation well-timed episiotomia of optimal size is necessary. Our good experiences in breech presentation between 31. and 35. week of gestation treated by obligate Caesarean section have to prove true in future.

Apgar Score↗
PubMed1978

Myasthenia gravis: further electrophysiological and ultrastructural analysis of transmission failure in the mouse passive transfer model.

Using the mouse passive transfer model the mean amplitude of miniature endplate potentials and endplate potentials of mice treated with myasthenic immunoglobulins was markedly decreased. Miniature endplate potential frequency and quantum content of endplate potentials were normal, arguing against a major presynaptic disarrangement. Under electron-microscopy no gross structural alterations of endplates were demonstrated. It is concluded that the mouse passive transfer model closely resembles human myasthenia gravis of recent onset.

Acetylcholine↗
PubMed1978

[Relationships between the macroscopic placentary condition and postnatal state of underweight neonates. A contribution to the correlational pathology of the placenta (author's transl)].

Results of macroscopic examinations of placentae, which were obtained under routine clinical conditions for a total of 615 underweight neonates, were checked for their capability of a respiratory distress syndrome, and perinatal mortality. Evidence was obtained for a (partially statistically significant) trend showing that, within individual gestatory age groups and for equal weights of babies, premature infants born in the period up to and including the thirty-fifth week of gestation and having relatively low placental weights premature babies born during the thirty-sixth week of pregnancy, and hypotrophic babies born at term and showing a relatively heigh weight of the placenta are particularly exposed to a number of dangers in the further postnatal course of life. The clinical importance of these results to attending neonatologists is pointed out. Other conditions. such as the form of attachment of the umbilical cord of the nature of allantochorial vasculature, were not found to be closely related to the parameters studied in this investigation.

Apgar Score↗
PubMed1978

[Relationships between the HPL determination in maternal serum and the condition of the associated placental villous trophoblast].

Relationships between the determination of human placental lactogen in materna serum and the condition of associated placental villous trophoblasts.--Taking as a starting point both qualitative and quantitative differences in the composition of placental villous trophoblasts subsequent to risk pregnancies, the proportions of different qualities of syncytium and average numbers of Langhans' cells per field of view in 24 placentas of neonates of the 37th to 41st weeks of pregnancy are compared with the corresponding maternal serum HPL (human placental lactogen) values. The significantly lower proportion of mature syncytium determined in the case of a low HPL value as well as the result of linear regression analysis are indicative of a dependence of maternal serum values for HPL upon the proportion of mature syncytium. This particular result is also interpreted by the authors as confirming the view that "mature" syncytium can be considered to be "functional" syncytium. Like other investigators, the present authors should also point out the importance of the total mass of placenta which can compensate for lower proportions of functional syncytium in individual resorption villi. Whereas there are clearly evident relationships between the maternal estriol values and the condition of placental villous trophoblasts, such relationships could not be observed in our material for oxytocinase and HSAP.

Alkaline Phosphatase↗
PubMed1977

[Macroscopically determined placentary conditions in the case of underweight neonates (author's transl)].

The placentary conditions (weight of placenta, placenta/infant weight index, kind of attachment of the umbilical cord and allantochorial vasculature) of underweight neonates (eutrophic premature infants and hypotrophic babies born at term), which were macroscopically determined under routine clinical conditions, are compared with those of eutrophic babies born at term after clinically and anamnestically normal pregnancies. Significantly lower weights of placenta and significantly higher placenta/infant weight indices of underweight neonates must be differently assessed for prematurely born babies and hypotrophic infants born at term. The significant increase in the case of underweight neonates of the disperse type of allantochorial vasculature does not suggest any significant relations to either lower weights of placenta or lower weights of newborn infants within the individual classification groups. There is no increase in the number of marginal-velamentous attachments of umbilical cords in the case of underweight neonates. Also, reference is made to the limited importance of macroscopically determined placentary conditions to individual cases.

Birth Weight↗
PubMed1975

[Assays of placenta-iso-enzyme of alkaline serum-phosphatase with disk-elektrophoresis (author's transl)].

Alkaline serum-phosphatase may be subdivided with disk-electrophoresis in 7% poly-acrylamid gel into the iso-enzymes: liver-cell, bone- and ileum-phosphatase. In the 7% gel liver-cell and placenta phosphatase move together. Separation of these two can be achieved by raising the gel-concentration to 10%. The method is suitable for quantitative densitometric evaluation.

Alkaline Phosphatase↗